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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
antinociception.
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "antinociception." in MCE Product Catalog:
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol (Standard) is the analytical standard of Allopurinol. This product is intended for research and analytical applications. Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .
Category:
Alkaloids Quinolizidine Alkaloids Mitragyna speciosa Korth. Plants Indole Alkaloids Rubiaceae Extract
Target:
Cat. No.: HY-110014
CAS No.: 222723-55-9
Target:
Research Areas:
Noladin ether is a potent and selective agonist of cannabinoid CB1 receptor, with a Ki of 21.2 nM. Noladin ether can cause hypothermia, intestinal immobility, and mild antinociception .
Cat. No.: HY-107561
CAS No.: 1227675-50-4
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Research Areas:
A-943931 (Compound 10) is a histamine H4 receptor antagonists. A-943931 has improved pharmacotropic and in vivo efficacy in models of pain and inflammation. A-943931 can be used in vivo anti-inflammatory and anti-nociception research .
Cat. No.: HY-144738
CAS No.: 2756099-59-7
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Research Areas:
Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC50 values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase .
Cat. No.: HY-B0219S1
Cat. No.: HY-W025736
CAS No.: 1687-53-2
Cat. No.: HY-162728
Target:
Research Areas:
RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC50 value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity .
Cat. No.: HY-101373
CAS No.: 104076-38-2
Synonyms: SK&F 95282
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Research Areas:
Zolantidine (SKF 95282) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine induces antinociception .
Cat. No.: HY-101373AR
CAS No.: 104076-39-3
Synonyms: SKF 95282 dimaleate (Standard)
Research Areas:
Zolantidine (dimaleate) (Standard) is the analytical standard of Zolantidine (dimaleate). This product is intended for research and analytical applications. Zolantidine dimaleate (SKF 95282 dimaleate) is a potent, selective and cross the blood-brain barrier histamine H2 antagonist. Zolantidine dimaleate induces antinociception .
Cat. No.: HY-172407
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Research Areas:
KOR agonist 5 (Compound 10a) is a KOR/MOR modulator with agonistic activity towards KOR and antagonistic activity towards MOR. KOR agonist 5 can effectively block morphine-induced antinociception and inhibition of intestinal motility. KOR agonist 5 can be used in the research of Substance Use Disorder (SUD) .
Cat. No.: HY-P1502F
Target:
Research Areas:
Cat. No.: HY-W020183R
CAS No.: 99-85-4
Target:
Cat. No.: HY-W020183S
Cat. No.: HY-119733
CAS No.: 1541206-05-6
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Research Areas:
BU09059 is a potent and selective Kappa-opioid receptor antagonist with a pA2 of 8.62. BU09059 has nanomolar affinity for the κ-receptor, with 15-fold and 616-fold selectivity over μ- and δ-receptors, respectively. BU09059 significantly blocks U50488 (HY-15997B)-induced antinociception .
Cat. No.: HY-10487R
CAS No.: 785835-79-2
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Research Areas:
JDTic dihydrochloride (Standard) is the analytical standard of JDTic dihydrochloride (HY-10487). This product is intended for research and analytical applications. JDTic dihydrochloride is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
Cat. No.: HY-103203A
CAS No.: 4751-48-8
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Research Areas:
ST91 free base is a α2-adrenoceptor (α2AR) agonist. ST91 free base activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception .
Cat. No.: HY-105389
CAS No.: 147441-56-3
Synonyms: RWJ-38705
Target:
Research Areas:
Tramadol N-oxide (RWJ 38705) is an analgesic. Tramadol N-oxide sproduces dose-related, long-lasting antinociception. Tramadol N-oxide has affinity for μ opioid receptor (Ki = 38.5 μM) and δ, κ receptors (Ki > 100 μM). Tramadol N-oxide can be used for the study of analgesic effect .
Research Areas:
(S)-(-)-Propranolol is the active isomer of Propranolol (HY-B0573B), with 98-fold greater activity than (R)-(+)-Propranolol. (S)-(-)-Propranolol produces antinociception-related phenotypes in mouse models, accompanied by sedative and ataxic side effects. (S)-(-)-Propranolol can be used in research related to hypertension, myocardial infarction, and pain .
Cat. No.: HY-103203R
CAS No.: 4749-61-5
Research Areas:
ST91 (Standard) is the analytical standard of ST91 (HY-103203). This product is intended for research and analytical applications. ST91 is a α2-adrenoceptor (α2AR) agonist. ST91 activates both α2AAR and non-α2AAR subtypes to produce spinal antinociception .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
