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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
459 Results for "
PROTAC compound
" in MedChemExpress (MCE) Product Catalog:
Products (459)
459 Results for "PROTAC compound" in MCE Product Catalog:
Cat. No.: HY-181501
Research Areas:
CDK2/4/6-IN-3 (compound 32a) is a CDK2/4/6 inhibitor. CDK2/4/6-IN-3 can be used as a target protein ligand for the synthesis of PROTAC WWZ-11-098 (HY-181490) .
Cat. No.: HY-189672
Target:
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GSDMD ligand-1 (compound A5) is a synthetic intermediate. GSDMD ligand-1 is used for conjugation with Thalidomide (HY-14658)/CRBN linker fragments to construct PROTACs targeting GSDMD. GSDMD ligand-1 can be used in cancer-related research .
Target:
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Propargyl-PEG8-NH2 (compound 3b) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG8-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-171774
CAS No.: 1997321-76-2
Research Areas:
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1 is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410) .
Cat. No.: HY-181735
Research Areas:
BET-IN-30 (Compound 11d) is a BTE family protein inhibitor, which can act as a BRD2/BRD3/BRD4 target protein ligand and be used for the synthesis of PROTACs, such as PROTAC BET Degrader-15 (HY-181729). BET-IN-30 exhibits potent anti-proliferative activity against acute myeloid leukemia (AML) cells such as MV4-11. BET-IN-30 can be used for the study of AML .
Cat. No.: HY-183072
Research Areas:
(S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH (Compound 12) is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand (HY-170348) and a PROTAC linker (HY-W586116). (S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH can be used for synthesis of PROTAC, such as CXJ2080 (HY-183070) .
Cat. No.: HY-184537
CAS No.: 2241294-16-4
Research Areas:
Desmethyl-QCA276-C3-alkyne (Compound 71) is a Target Protein Ligand-Linker Conjugate, composed of the BET ligand Desmethyl-QCA276 (HY-44103) and the PROTAC linker (HY-W035972). Desmethyl-QCA276-C3-alkyne is applicable for the synthesis of the PROTAC QCA570 (HY-112609). Desmethyl-QCA276-C3-alkyne is used in cancer research .
Cat. No.: HY-156751A
CAS No.: 2753651-10-2
Synonyms: RO7656594
Target:
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GDC-2992 (Compound 28A) is an orally bioavailable androgen receptor (AR) PROTAC degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells. GDC-2992 can be used for prostatic cancer study .
Cat. No.: HY-162626
CAS No.: 3080487-43-7
FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase) .
Cat. No.: HY-185003
CAS No.: 1571081-31-6
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α1A-AR ligand-1 (Compound 3) is an α1A-AR ligand that can be used to synthesize PROTACs, such as α1A-AR Degrader 9c (HY-147100) .
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(S)-2,3,4,5-Tetrahydrodipicolinic acid is a TMPBM-linker-E3 ligase binding compound. (S)-2,3,4,5-Tetrahydrodipicolinic acid is an intermediate. (S)-2,3,4,5-Tetrahydrodipicolinic acid can be used for the synthesis of PROTAC .
Cat. No.: HY-187196
Target:
Research Areas:
ATR/AURKA-ligand 1 (Compound 8g) is a ATR/AURKA ligand. ATR/AURKA-ligand 1 serves as a target protein ligand for the synthesis of ATR/AURKA PROTAC degraders, such as Abd141 (HY-187195). ATR/AURKA-ligand 1 is applicable to the research of acute lymphoblastic leukemia .
Cat. No.: HY-139341
CAS No.: 2357108-05-3
Research Areas:
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .
Cat. No.: HY-139343
CAS No.: 2296708-61-5
Research Areas:
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .
Cat. No.: HY-163875
CAS No.: 2568277-48-3
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
Cat. No.: HY-163876
CAS No.: 2568277-50-7
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
Cat. No.: HY-183939
CAS No.: 2760138-46-1
Target:
Research Areas:
L1-CIDE-BRM1-13 (Compound 15) is a linker-drug precursor moiety formed by the covalent conjugation of a PROTAC degrader with a linker for degrader-antibody conjugates (DACs). L1-CIDE-BRM1-13 can be used for the synthesis of DACs .
Cat. No.: HY-130814
CAS No.: 2093387-50-7
Research Areas:
Thalidomide-NH-C4-NH2 TFA (compound 29c) is an E3 ligase ligand-linker conjugate, and incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-NH-C4-NH2 TFA is used in PROTAC BRD2/BRD4 degrader-1 (HY-130612). PROTAC BRD2/BRD4 degrader-1 is a potent and selective BET protein BRD4 and BRD2 degrader .
Research Areas:
Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC50 of 59 nM . Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively .
Synonyms: mPEG10000-Hydroxy; Polyethylene glycol monomethyl ether 10000
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
