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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
595 Results for "
dNTPases/NUDIX hydrolases
" in MedChemExpress (MCE) Product Catalog:
Products (595)
595 Results for "dNTPases/NUDIX hydrolases" in MCE Product Catalog:
Cat. No.: HY-E71264
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β-Acetylglucosaminidase 18A, Bacteroides thetaiotaomicron (EC 3.2.1.96), is an enzyme from Bacteroides thetaiotaomicron that participates in the endohydrolysis of the diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the (Man (GlcNAc) (2) ) Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. Recombinant BtAcp18A (GH18) , purified from Escherichia coli, is a single domain family 18 Glycoside Hydrolase (GH18) .
Cat. No.: HY-E71889
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5-(3,4-diacetoxybut-1-ynyl)-2,2'-Bithiophene deacetylase (EC 3.1.1.66) is a hydrolase that can convert 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene and H2O into 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene, acetate and H +.
Cat. No.: HY-E71951
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6-Aminohexanoate-oligomer exohydrolase (EC 3.5.1.46) is a hydrolase that can catalyze multiple reactions, including reaction 1: convert [N-(6-aminohexanoyl)](n) and H2O into [N-(6-aminohexanoyl)](n-1) and 6-aminohexanoate; reaction 2: convert N-(6-aminohexanoyl)-6-aminohexanoate and H2O into 2 6-aminohexanoate.
Cat. No.: HY-N21974
CAS No.: 152041-26-4
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Cat. No.: HY-P2769A
CAS No.: 37288-57-6
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Thermostable β-Agarase is a hydrolase that can hydrolyze the β-1,4 linkages in agarose to produce neoagaro-oligosaccharides, and it can be used to extract DNA and RNA from gels. Compared to conventional β-Agarase, Thermostable β-Agarase exhibits higher heat resistance and stronger hydrolytic activity. The thermostable properties of Thermostable β-Agarase simplify experimental procedures and make it suitable for the rapid purification of intact large DNA molecules .
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Sophorose (2-O-beta-D-Glucopyranosyl-D-glucopyranose) is a disaccharide linked by a β-1,2-glycosidic bond; it can be synthesized from high concentrations of glucose via the transglycosylation reaction of glycoside hydrolases. Sophorose is the most potent soluble inducer of Trichoderma reesei cellulase, and a glucose-sophorose mixture (MGDC) can be used as a combined carbon source and inducer for Trichoderma cellulase fermentation. Sophorose is suitable for use in metabolism-related research .
Synonyms: 2-O-beta-D-Glucopyranosyl-D-glucopyranose monohydrate
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Sophorose monohydrate (2-O-beta-D-Glucopyranosyl-D-glucopyranose monohydrate) is a disaccharide linked by a β-1,2-glycosidic bond; it can be synthesized from high concentrations of glucose via the transglycosylation reaction of glycoside hydrolases. Sophorose monohydrate is the most potent soluble inducer of Trichoderma reesei cellulase, and a glucose-Sophorose monohydrate mixture (MGDC) can be used as a combined carbon source and inducer for Trichoderma cellulase fermentation. Sophorose monohydrate is suitable for use in metabolism-related research .
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Tiadenol is an orally effective lipid-lowering compound and peroxisome proliferator. Tiadenol promotes peroxisome-associated fatty acid metabolism, and its induction of the activities of enzymes such as palmitoyl-CoA hydrolase, carnitine acetyl-transferase and catalase is mainly associated with de novo protein synthesis. The triglyceride-lowering effect of Tiadenol is not accompanied by increased activities of lipoprotein lipase (LPL) and hepatic lipase (HL), and it reduces VLDL Apo E. Tiadenol can be used in studies related to lipid metabolism, peroxisome proliferation and hyperlipoproteinemia .
Cat. No.: HY-173276
CAS No.: 3069378-18-0
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SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).
Cat. No.: HY-E71158
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1,4-Dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) is involved in the synthesis of 1,4-Dihydroxy-2-naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K2, in bacteria) , phylloquinone (vitamin K1 in plants) , and many plant pigments.The coenzyme A group is subsequently removed from the product by EC 3.1.2.28, 1,4-Dihydroxy-2-naphthoyl-CoA hydrolase.
Cat. No.: HY-E71239A
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α-Glucuronidase 4A, Thermotoga maritima (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction: an alpha-D-glucuronoside + H2O ? an alcohol + D-glucuronate. Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H2O, whereas its two products are alcohol and D-glucuronate. α-Glucuronidase 4A, Thermotoga maritima (EC 3.2.1.139) belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O-and S-glycosyl compounds.
Cat. No.: HY-E71366
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Endo-1,4-β-D-glucanase is a glycoside hydrolase that cleaves internal β-1,4-glycosidic bonds in cellulose and related β-D-glucans (β-D-Glucan) (HY-139413). Endo-1,4-β-D-glucanase randomly cuts long, insoluble cellulose polymer chains into shorter, soluble fragments such as oligosaccharides, thereby paving the way for further digestion into glucose .
Cat. No.: HY-E71989
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7,8-Dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase (EC 3.1.4.56) is a hydrolase that can catalyze multiple reactions, including reaction 1: convert 7,8-dihydroneopterin 2',3'-cyclic phosphate and H2O into 7,8-dihydroneopterin 3'-phosphate and H +; reaction 2: convert 7,8-dihydroneopterin 2',3'-cyclic phosphate and H2O into 7,8-dihydroneopterin 2'-phosphate and H +.
Cat. No.: HY-P2858H
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β-Mannosidase, Streptomyces coelicolor (EC 3.2.1.25) catalyses the following chemical reaction:Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.
Cat. No.: HY-10862R
CAS No.: 326866-17-5
Synonyms: Benzothiazole analog 3 (Standard)
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FAAH inhibitor 1 (Standard) is the analytical standard of FAAH inhibitor 1 (HY-10862). This product is intended for research and analytical applications. FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC50 value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research .
Synonyms: EPA-5-HT
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Eicosapentaenoyl serotonin (EPA-5-HT) is an endogenous fatty acid-serotonin conjugate lipid mediator. Eicosapentaenoyl serotonin acts as an inhibitor of fatty acid amide hydrolase (FAAH). Eicosapentaenoyl serotonin suppresses IL-17 release in Concanavalin A (HY-P2149)-stimulated human peripheral blood mononuclear cells. Eicosapentaenoyl serotonin is regulated by polyunsaturated fatty acids and modulates intestinal immunity and Th17 signaling. Eicosapentaenoyl serotonin can be used for the study of inflammatory bowel disease-related mechanisms .
Synonyms: 4-MUB
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4-Methylumbelliferyl butyrate (4-MUB) is a fluorogenic esterase substrate that is hydrolyzed by esterases to release the fluorescent product 4-methylumbelliferone (HY-N0187). 4-Methylumbelliferyl butyrate is hydrolyzed by the general esterases (GE) of Daphnia magna and Chironomus riparius; it also serves as a substrate for the recombinant mycobacterial carboxylesterase MT2282 (CaeA). 4-Methylumbelliferyl butyrate is used to determine the activity of the S. aureus serine hydrolases FphB and FphH. 4-Methylumbelliferyl butyrate is used in studies related to esterase activity assays .
Cat. No.: HY-152251
CAS No.: 928892-60-8
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CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production .
Cat. No.: HY-164495
CAS No.: 2128258-47-7
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Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome (HY-14823) to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice .
Cat. No.: HY-164628
CAS No.: 314039-40-2
CD38-IN-5 (compound 1) is a CD38 inhibitor that selectively inhibits CD38 hydrolase with an IC50 of 4.0 μM. CD38-IN-5 does not inhibits CD38 cyclase. CD38-IN-5 is highly effective at promoting NK cell-mediated tumor toxicity. CD38-IN-5 increases NADH+ and IFNγ levels in activated PBMCs. CD38-IN-5 can be used for the study of cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
