10240 Results for "

Inhibiting

" in MedChemExpress (MCE) Product Catalog:
Products (10240)

10240 Results for "Inhibiting" in MCE Product Catalog:

37
37 Cited Publications
Cat. No.: HY-12495A
CAS No.: 548470-11-7
Purity:  98.58%
ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research .
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37
37 Cited Publications
Cat. No.: HY-P9902
CAS No.: 1374853-91-4
Synonyms: MK-3475; Lambrolizumab

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy.
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37
37 Cited Publications
Cat. No.: HY-P0017
CAS No.: 9087-70-1
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
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34
34 Cited Publications
Cat. No.: HY-N0088
CAS No.: 498-02-2
Synonyms: Acetovanillone
Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM . Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model . Apocynin can also be used for cancer research . Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass .
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32
32 Cited Publications
Cat. No.: HY-15247
CAS No.: 1009298-59-2
Purity:  99.32%
Synonyms: AZD2014
Target:  

mTOR Autophagy Apoptosis

Research Areas:  

Cancer

Vistusertib (AZD2014) is an ATP competitive mTOR inhibitor with an IC50 of 2.81 nM. AZD2014 inhibits both mTORC1 and mTORC2 complexes.
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30
30 Cited Publications
Cat. No.: HY-107433
CAS No.: 3039-71-2
Purity:  99.77%
Research Areas:  

Infection Neurological Disease

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus .
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29
29 Cited Publications
Cat. No.: HY-N1724
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B; Folimycin; X 4357B
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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29
29 Cited Publications
Cat. No.: HY-N1724A
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)
Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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29
29 Cited Publications
Cat. No.: HY-108341
CAS No.: 1469284-78-3
Purity:  99.89%
Target:  

Acyltransferase

Research Areas:  

Metabolic Disease

PF-06424439 is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM . PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .
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26
26 Cited Publications
Cat. No.: HY-10172
CAS No.: 978-62-1
Purity:  99.26%
Synonyms: IKK2 Inhibitor V
Target:  

IKK

Research Areas:  

Cancer

IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM .
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25
25 Cited Publications
Cat. No.: HY-10158
CAS No.: 380843-75-4
Purity:  99.89%
Synonyms: SKI-606
Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively .
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25
25 Cited Publications
Cat. No.: HY-10158A
CAS No.: 918639-08-4
Purity:  99.97%
Synonyms: SKI-606 hydrate
Target:  

Src Bcr-Abl

Research Areas:  

Cancer

Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively .
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25
25 Cited Publications
Cat. No.: HY-107994A
CAS No.: 645-88-5
Synonyms: Carboxymethoxylamine; Aminooxyacetate
Target:  

GABA Receptor

Research Areas:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.
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25
25 Cited Publications
Cat. No.: HY-107994
CAS No.: 2921-14-4
Purity:  ≥98.0%
Synonyms: Carboxymethoxylamine hemihydrochloride; Aminooxyacetate hemihydrochloride
Target:  

GABA Receptor

Research Areas:  

Cancer

Aminooxyacetic acid (Carboxymethoxylamine) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T.
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25
25 Cited Publications
Cat. No.: HY-15282
CAS No.: 66701-25-5
Purity:  99.95%
Synonyms: Proteinase inhibitor E 64
Research Areas:  

Inflammation/Immunology Cancer

E-64 (Proteinase inhibitor E 64) is a potent irreversible inhibitor against general cysteine proteases with IC50 of 9 nM for papain.
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24
24 Cited Publications
Cat. No.: HY-N0183
CAS No.: 485-72-3
Synonyms: Biochanin B; Flavosil; Formononetol
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth .
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23
23 Cited Publications
Cat. No.: HY-N0931
CAS No.: 1477949-42-0
Synonyms: CAY-10683
Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research .
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23
23 Cited Publications
Cat. No.: HY-D0086
CAS No.: 67483-13-0
Synonyms: MDL101114ZA
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits RAD51, inhibiting RAD51-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .
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23
23 Cited Publications
Cat. No.: HY-15457
CAS No.: 35943-35-2
Purity:  98.62%
Synonyms: API-2; NSC 154020; TCN
Target:  

DNA/RNA Synthesis Akt HIV

Research Areas:  

Infection Cancer

Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC50 of 130 nM, and 0.02-0.46 μM, respectively.
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22
22 Cited Publications
Cat. No.: HY-50909
CAS No.: 157716-52-4
Synonyms: KRX-0401; NSC 639966; D21266
Target:  

Akt Autophagy Apoptosis

Research Areas:  

Cancer

Perifosine is an oral Akt inhibitor which inhibits proliferation of different tumor cell lines with IC50s of 0.6-8.9 μM.
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