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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
464 Results for "
USP
" in MedChemExpress (MCE) Product Catalog:
Products (464)
464 Results for "USP" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50=~20 nM), with high selectivity over other DUB family members (1-100 μM). CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy). CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients .
2
Target:
Research Areas:
KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers .
2
2 Cited Publications
Target:
Research Areas:
USP7-IN-3 (Compound 5) is an effective and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7). USP7-IN-3 can be used for research on acute lymphoblastic leukemia .
2
2 Cited Publications
Target:
Research Areas:
C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
2
2 Cited Publications
Cat. No.: HY-145471A
CAS No.: 2938991-80-9
Target:
Research Areas:
KSQ-4279 (gentisate) (Compound Formula I) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 (gentisate) is promising for research of cancers .
1
1 Cited Publications
Target:
Research Areas:
USP7-IN-8 (example 81) is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM in an Ub-Rho110 assay. USP7-IN-8 shows no activity against USP47 and USP5. USP7-IN-8 has anticancer effects .
1
1 Cited Publications
Cat. No.: HY-P71418
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP14; Ubiquitin Specific Peptidase 14; TGT; Ubp6; Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase); Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase); Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14; Ubiqu
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P701431
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP9X; Ubiquitin Specific Peptidase 9 X-Linked; DFFRX; FAF-X; MRX99; FAF; Ubiquitin Specific Protease 9, X Chromosome (Fat Facets-Like Drosophila); Ubiquitin-Specific Protease 9, X Chromosome; Ubiquitin Carboxyl-Terminal Hydrolase 9X; Deubiquitinating Enz
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P701447
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP28; Ubiquitin Specific Peptidase 28; Ubiquitin-Specific-Processing Protease 28; Ubiquitin Carboxyl-Terminal Hydrolase 28; Deubiquitinating Enzyme 28; Ubiquitin Thioesterase 28; KIAA1515; Ubiquitin Carboxyl-Terminal Hydrolase; Ubiquitin Specific Proteas
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P702063
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: USP11; Ubiquitin Specific Peptidase 11; UHX1; Ubiquitin Carboxyl-Terminal Hydrolase 11; Deubiquitinating Enzyme 11; Ubiquitin Thioesterase 11; Ubiquitin Carboxyl-Terminal Hydrolase, X-Linked; Ubiquitin-Specific Processing Protease 11; Ubiquitin-Specific-P
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P702603
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal Hydrolase 7; Deubiquitinating Enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74478
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP7; HAUSP; Ubiquitin Specific Peptidase 7; Ubiquitin-Specific-Processing Protease 7; Ubiquitin Carboxyl-Terminal Hydrolase 7; Deubiquitinating Enzyme 7; Ubiquitin Thioesterase 7; Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated); Herpesvirus-Asso
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P703232
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: USP4; Ubiquitin Specific Peptidase 4; UNP; Unph; Ubiquitin Specific Peptidase 4 (Proto-Oncogene); Ubiquitin Carboxyl-Terminal Hydrolase 4; Ubiquitous Nuclear Protein Homolog; Deubiquitinating Enzyme 4; Ubiquitin Thioesterase 4; Ubiquitin Specific Protease
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701411
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP15; Ubiquitin Specific Peptidase 15; KIAA0529; UNPH4; Ubiquitin-Specific-Processing Protease 15; Ubiquitin Carboxyl-Terminal Hydrolase 15; Deubiquitinating Enzyme 15; Ubiquitin Thioesterase 15; Ubiquitin Specific Protease 15; Ubiquitin Thiolesterase 15
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P701450
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: USP30; Ubiquitin Specific Peptidase 30; Ubiquitin-Specific-Processing Protease 30; Ubiquitin Carboxyl-Terminal Hydrolase 30; Deubiquitinating Enzyme 30; Ubiquitin Thioesterase 30; Ub-Specific Protease 30; MGC10702; FLJ40511; Ubiquitin Carboxyl-Terminal Hy
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Target:
Research Areas:
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
1
1 Cited Publications
Target:
Research Areas:
FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM .
1
1 Cited Publications
Target:
Research Areas:
XL 188 is a potent and selective USP7 inhibitor with IC50 values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer .
1
1 Cited Publications
Target:
Research Areas:
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .
1
1 Cited Publications
Synonyms: LCA hydroxyamide
Target:
Research Areas:
LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
