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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
fXa
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "fXa" in MCE Product Catalog:
Cat. No.: HY-10264C
CAS No.: 480448-29-1
Synonyms: DU-176 hydrochloride
Research Areas:
Edoxaban (DU-176b) hydrochloride is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban hydrochloride exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban hydrochloride can be used for preventing thromboembolic disease research .
Cat. No.: HY-P4576
CAS No.: 104186-68-7
Cat. No.: HY-I0454
CAS No.: 1151893-81-0
Target:
Research Areas:
Rivaroxaban EP Impurity I is an impurity of Rivaroxaban (HY-50903). Rivaroxaban EP Impurity I can be used to ensure the purity of Rivaroxaban. Rivaroxaban is a highly potent, selective and direct Factor Xa (FXa) inhibitor .
Cat. No.: HY-10268S1
CAS No.: 2098655-55-9
Synonyms: PRT054021-dsub>4
Cat. No.: HY-163347
Target:
Research Areas:
FXIIa-IN-3 (Compound 8) is a potent and selective Factor XIIa (FXIIa) inhibitor, with an IC50 of 0.045 μM. FXIIa-IN-3 also exhibits a substantial margin of selectivity against related serine proteases, including FXIa, FXa, and FIXa. FXIIa-IN-3 can be used for the research of thromboembolic diseases .
Cat. No.: HY-10762
CAS No.: 209285-82-5
Target:
Research Areas:
FXa-IN-3 (compound 1a) is a potent coagulation factor Xa (FXa) inhibitor with a Ki of 43 nM. FXa-IN-3 can be used in the research of thromboembolic diseases .
Cat. No.: HY-W756265
Research Areas:
(R)-(-)-N-Boc-3-pyrrolidinol-d4 is the d4-labeled (R)-(-)-N-Boc-3-pyrrolidinol (HY-W001294). (R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia .
Cat. No.: HY-137070
CAS No.: 1160170-00-2
Target:
Research Areas:
Rivaroxaban diol is a metabolite of Rivaroxaban (HY-50903). Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM) .
Cat. No.: HY-187960
CAS No.: 247131-06-2
Research Areas:
JTV-803 is a selective and competitive direct factor Xa (FXa) inhibitor with a Ki of 19 nM and an IC50 of 81 nM against human FXa, and its action is independent of antithrombin III (ATIII). JTV-803 exhibits significantly higher selectivity for human FXa than for thrombin, plasmin, and trypsin. JTV-803 produces sustained ex vivo anti-FXa inhibitory activity in vivo. JTV-803 prolongs aPTT and PT, prevents dialyzer thrombosis, and is cleared during dialysis. JTV-803 dose-dependently attenuates coagulation activation, maintains plasma ATIII activity, reduces glomerular fibrin deposition, and improves survival rate . JTV-803 can be used for research related to thrombosis and hemodialysis anticoagulation .
Cat. No.: HY-Z4525
CAS No.: 2244103-96-4
Synonyms: Edoxaban N-oxide
Target:
Research Areas:
Edoxaban impurity 15 (Edoxaban N-oxide) is an impurity of Edoxaban (HY-10264). Edoxaban (DU-176b) is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Ki values of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban can be used in preventing thromboembolic disease research.
Cat. No.: HY-10264BR
CAS No.: 1229194-11-9
Synonyms: DU-176b monohydrate (Standard)
Target:
Research Areas:
Edoxaban tosylate monohydrate (Standard) is the analytical standard of Edoxaban tosylate monohydrate (HY-10264B). This product is intended for research and analytical applications. Edoxaban (DU-176b) monohydrate is an orally active, highly potent, selective, and direct Factor Xa (FXa) inhibitor with Kis of 0.561 and 2.98 nM for free human FXa and prothrombinase. Edoxaban monohydrate exhibits more than 10,000-fold selectivity over other coagulation proteases. Edoxaban monohydrate can be used for preventing thromboembolic disease research .
Cat. No.: HY-100652
CAS No.: 1118765-14-2
Target:
Research Areas:
O-Desmethyl apixaban sulfate is the major circulating metabolite of Apixaban (HY-50667) in humans. O-Desmethyl apixaban sulfate exhibits no inhibitory activity against human activated factor X (FXa), with a Ki > 20 μM .
Cat. No.: HY-10268S2
Synonyms: PRT054021-13C6
Target:
Research Areas:
Neutrophil elastase-IN-7 is a human neutrophil elastase inhibitor with an IC50 of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against multiple coagulation proteins, with IC50 values of 8.2, 12.7, 1.2 and 5.7 μM against thrombin, FXa, FXIa and FXIIIa, respectively. Neutrophil elastase-IN-7 can be used in the research of cardiopulmonary diseases and inflammatory diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
