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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
61 Results for "
worm
" in MedChemExpress (MCE) Product Catalog:
Products (61)
61 Results for "worm" in MCE Product Catalog:
Cat. No.: HY-101258
CAS No.: 79473-24-8
Cardol triene is a phenol found in cashew nut shell liquid that competitively and irreversibly inhibits mushroom tyrosinase (IC50=22.5 μM). It is schistosomicidal, killing 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 μM, respectively. It has been used as a starting material for the synthesis of bis-benzoxazines.
Cat. No.: HY-B0778R
CAS No.: 129496-10-2
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Cat. No.: HY-122522
CAS No.: 50423-15-9
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2-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC50=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.
Cat. No.: HY-144098
CAS No.: 2824131-20-4
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs .
Cat. No.: HY-175185
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MC3935 is a LSD1 inhibitor with an IC50 of 0.52 μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .
Cat. No.: HY-12639AR
CAS No.: 3818-50-6
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Bephenium hydroxynaphthoate (Standard) is the analytical standard of Bephenium hydroxynaphthoate (HY-12639A). This product is intended for research and analytical applications. Bephenium hydroxynaphthoate is an orally active anthelmintic with anthelmintic activity against hookworms and roundworms. Bephenium hydroxynaphthoate reduces egg counts, promotes worm expulsion, and most expelled roundworms die at approximately 24 h, while the rest show weakened activity. Bephenium hydroxynaphthoate can be used in research related to ascariasis, hookworm infection, and roundworm infection .
Cat. No.: HY-N7854
CAS No.: 103904-74-1
Synonyms: Anacardic acid 15:2
Anacardic acid diene is a polyunsaturated form of anacardic acid (HY-N2020) that has been found in cashew nut shell liquid. It has antibacterial activity against methicillin resistant S. aureus (MRSA) and S. mutans (MICs=12.5 and 6.25 μg/mL, respectively). Anacardic acid diene has schistosomicidal activity against adult S. mansoni worms when used at a concentration of 100 μM. It also inhibits soybean lipoxygenase-1 in a time-dependent manner.
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Cat. No.: HY-126638
CAS No.: 75731-43-0
Synonyms: NSC 324645
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Alkaloids Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Indole Alkaloids
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Cat. No.: HY-172356A
Cat. No.: HY-136897
CAS No.: 65195-54-2
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Cat. No.: HY-187528
GPCR antagonist-2 is a GPCR antagonist with macrofilaricidal activity. GPCR antagonist-2 shows inhibitory effects on Brugia pahangi adult females and males (IC50 = 3.9 μM and 2.8 μM, respectively) and Onchocerca ochengi adult females and males (IC50 = 0.35 μM and 1.7 μM, respectively). GPCR antagonist-2 reduces B. pahangi worm burden and affects female fecundity and embryogenesis, downregulates GPCR expression in surviving adult female worms and can be used for the study of filarial infections, including onchocerciasis (river blindness) .
Cat. No.: HY-N0176S6
CAS No.: 252043-36-0
Synonyms: Dihydroqinghaosu-d; β-Dihydroartemisinin-d; Artenimol-d
Cat. No.: HY-114150B
CAS No.: 1262750-87-7
D-Val-Leu-Arg-pNA hydrochloride is a substrate for glandular kinin-releasing enzymes. D-Val-Leu-Arg-pNA hydrochloride can be used to determine the activities of plasminogen activator and plasmin. D-Val-Leu-Arg-pNA hydrochloride is also used to study the fibrinolytic activity of various organisms, such as bacteria and worms .
Cat. No.: HY-189461
Antiparasitic agent-48 is an orally active Schistosoma mansoni cathepsin B1 (SmCB1) modulator that exerts antischistosomal effects by stably binding to the enzyme active site, with an IC50 of 50.74 μM. It induces tegumental disruption, modulates immune responses, inhibits hepatic granuloma formation, and reduces worm burden and tissue egg burden. Antiparasitic agent-48 can be used for research on schistosomiasis .
Stilbazium iodide is an orally effective pyridinium quaternary ammonium repellent. Stilbazium (iodide) exhibits broad-spectrum activity against a variety of human and animal intestinal parasites. Stilbazium iodide eliminates both mature and immature worms, reduces egg counts, reddens feces, and causes mild gastrointestinal irritation. Stilbazium iodide can be used in research related to intestinal parasitic infections including pinworm, whipworm, and strongyloidiasis .
Cat. No.: HY-19392
CAS No.: 263754-93-4
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LA-419 is an orally active nitric oxide (NO) donor. LA-419 can significantly reduce the amount of fecal worm eggs excreted, shorten the duration of egg excretion, and also decrease the number of larvae in the lungs and the number of parasitic females in the intestines in mice infected with S. venezuelensis. LA-419 can reduce the formation of atherosclerosis in apolipoprotein E-deficient mice. LA-419 can be used for the researches of infection and cardiovascular disease .
Cat. No.: HY-183426
CAS No.: 2704554-86-7
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MMH409 is a selective HDAC8 inhibitor, with an IC50 value of 23 nM and a Kd value of 3.5 nM against human HDAC8, and an IC50 value of 11.64 μM against Schistosoma mansoni HDAC8. MMH409 reduces the viability of newly transformed schistosomula and adult worms of Schistosoma mansoni in vitro. MMH409 serves as a biological probe to investigate the pharmacological knockdown effect of HDAC8 in diseased cells. MMH409 can be used in studies related to neuroblastoma and schistosomiasis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
