Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
68 Results for "
GABA binding
" in MedChemExpress (MCE) Product Catalog:
Products (68)
68 Results for "GABA binding" in MCE Product Catalog:
製品番号: HY-114076
CAS 番号: 150175-54-5
Target:
研究分野:
CGP55845 is a potent and selective GABAB receptor antagonist with activity that blocks agonist binding. The IC50 value of CGP55845 is 5 nM, indicating that it exhibits significant activity in inhibiting GABA and glutamate release. The apparent Kd of CGP55845 when forming a complex with the GABAB receptor is 30 nM, indicating its high affinity for this receptor. CGP55845 is as potent as 100 μM CGP 35348 in relieving the inhibitory effect of (R)-(-)-baclofen .
製品番号: HY-W055872R
CAS 番号: 26116-56-3
Target:
研究分野:
γ-Aminobutyric acid (Standard) is the analytical standard of γ-Aminobutyric acid. This product is intended for research and analytical applications. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .
製品番号: HY-10061A
CAS 番号: 477956-38-0
別名: AZD-3355 napadisylate
Target:
研究分野:
Lesogaberan (AZD-3355) napadisylate is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan napadisylate for rat GABAB and GABAA receptors, as measured by displacement of [ 3H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan napadisylate inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action .
製品番号: HY-B0696AR
CAS 番号: 145821-59-6
別名: NO050328 hydrochloride (Standard); NO328 hydrochloride (Standard); TGB hydrochloride (Standard)
Target:
研究分野:
Tiagabine (hydrochloride) (Standard) is the analytical standard of Tiagabine (hydrochloride). This product is intended for research and analytical applications. Tiagabine hydrochloride (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine hydrochloride exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine hydrochloride is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease .
製品番号: HY-B0696AS
別名: NO050328-d4 hydrochloride; NO328-d4 hydrochloride; TGB-d4 hydrochloride
製品番号: HY-B0696S
CAS 番号: 1217672-34-8
別名: NO050328-d6; NO328-d6; TGB-d6
製品番号: HY-129090
CAS 番号: 77779-50-1
Target:
研究分野:
CGS-9895 is a GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors .
製品番号: HY-183471
CAS 番号: 34966-41-1
別名: SQ 65396
Target:
研究分野:
Cartazolate (SQ 65396) is a pyrazolopyridine modulator with benzodiazepine receptor agonist activity and cyclic AMP phosphodiesterase inhibitory activity. Cartazolate enhances the affinity of 3H-diazepam for brain-specific binding sites, regulates the GABA/benzodiazepine receptor complex, reversibly increases Na +-independent GABA receptor binding sites, and stimulates the binding of [ 3H]flunitrazepam to cerebellar membranes. Cartazolate restores punishment-suppressed behavior and exhibits anxiolytic properties. Cartazolate is applicable to anxiety-related research .
Target:
研究分野:
GABA-IN-4 (Compound 17) is a N-(indol-3-ylglyoxylyl)benzylamine derivative. GABA-IN-4 exhibits high affinity for the benzodiazepine receptor (BzR) (binding site in GABAA receptor complex) with Ki value of 67 nM. Benzodiazepines are widely used as antianxiety, sedative-hypnotic and anticonvulsant agents .
製品番号: HY-P72166
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: DBI; EP; Diazepam binding Inhibitor, Acyl-CoA binding Protein; Diazepam binding Inhibitor (GABA Receptor Modulator, Acyl-CoA binding Protein); ACBP; Cholecystokinin-Releasing Peptide, Trypsin-Sensitive; Acyl-CoA-binding Protein; Acyl-Coenzyme A binding Do
Species:
Human
Source:
E. coli
製品番号: HY-P72167
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: DBI; EP; Diazepam binding Inhibitor, Acyl-CoA binding Protein; Diazepam binding Inhibitor (GABA Receptor Modulator, Acyl-CoA binding Protein); ACBP; Cholecystokinin-Releasing Peptide, Trypsin-Sensitive; Acyl-CoA-binding Protein; Acyl-Coenzyme A binding Do
Species:
Mouse
Source:
E. coli
製品番号: HY-P700627
純度: ≥ 90%, as determined by reducing SDS-PAGE.
別名: DBI; EP; Diazepam binding Inhibitor, Acyl-CoA binding Protein; Diazepam binding Inhibitor (GABA Receptor Modulator, Acyl-CoA binding Protein); ACBP; Cholecystokinin-Releasing Peptide, Trypsin-Sensitive; Acyl-CoA-binding Protein; Acyl-Coenzyme A binding Do
Species:
Mouse
Source:
P. pastoris
製品番号: HY-189042
CAS 番号: 738562-57-7
Target:
研究分野:
EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases .
製品番号: HY-121554
CAS 番号: 68642-64-8
Target:
研究分野:
Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [ 3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia [1][2]
製品番号: HY-B1803
CAS 番号: 41094-88-6
別名: ICI 136753
Target:
研究分野:
Tracazolate (ICI 136753) is an orally active non-benzodiazepine anxiolytic. Tracazolate significantly enhances the binding of the radioligand 3H-flunitrazepam ( 3H-FLU) to brain tissue benzodiazepine receptors. Tracazolate enhances the binding of γ-aminobutyric acid (GABA) to its receptors. Tracazolate exhibits anticonvulsant activity. Tracazolate can be used in anxiety-related research .
製品番号: HY-P70861
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: GABARAP; Epididymis Secretory Sperm binding Protein; GABA Type A Receptor-Associated Protein; GABARAP-A; GABA(A) Receptor-Associated Protein; HCG1987397, Isoform CRA_b; MM46; GABARAP Protein; ATG8A; FLC3B; Gamma-Aminobutyric Acid Receptor-Associated Prote
Species:
Human
Source:
E. coli
製品番号: HY-P72639
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: GABARAP; Epididymis Secretory Sperm binding Protein; GABA Type A Receptor-Associated Protein; GABARAP-A; GABA(A) Receptor-Associated Protein; HCG1987397, Isoform CRA_b; MM46; GABARAP Protein; ATG8A; FLC3B; Gamma-Aminobutyric Acid Receptor-Associated Prote
Species:
Human
Source:
E. coli
製品番号: HY-P76942
純度: ≥ 85%, as determined by reducing SDS-PAGE.
別名: GABARAP; Epididymis Secretory Sperm binding Protein; GABA Type A Receptor-Associated Protein; GABARAP-A; GABA(A) Receptor-Associated Protein; HCG1987397, Isoform CRA_b; MM46; GABARAP Protein; ATG8A; FLC3B; Gamma-Aminobutyric Acid Receptor-Associated Prote
Species:
Human
Source:
E. coli
製品番号: HY-P705919
純度: ≥ 95%, as determined by reducing SDS-PAGE.
別名: GABARAP; Epididymis Secretory Sperm binding Protein; GABA Type A Receptor-Associated Protein; GABARAP-A; GABA(A) Receptor-Associated Protein; HCG1987397, Isoform CRA_b; MM46; GABARAP Protein; ATG8A; FLC3B; Gamma-Aminobutyric Acid Receptor-Associated Prote
Species:
Human
Source:
E. coli
製品番号: HY-114811
CAS 番号: 25006-32-0
Target:
Leptophos oxon, a metabolite of leptophos, is a GABAA receptor chloride channel inhibitor with an IC50 values of 89.6 μM. Leptophos oxon inhibits GABA-induced chloride influx, binds to GABAA receptor-associated TBPS sites, and inhibits TBPS binding to voltage-dependent chloride channels. Leptophos oxon is a insecticide. Leptophos oxon can be used for the research of neurological disease .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
