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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
281 Results for "
variants
" in MedChemExpress (MCE) Product Catalog:
Products (281)
281 Results for "variants" in MCE Product Catalog:
1
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ZEN-3694 (BET-IN-19) is an orally active BET inhibitor. ZEN-3694 regulates the function of BET proteins, thereby downregulating pathways involved in cell cycle regulation, ER signaling, AR signaling, AR splice variants, MYC, GR, cell growth, inflammation, and cellular immune responses. ZEN-3694 inhibits proliferation, induces apoptosis, reverses the upregulation of CDK6 and CCND1, restores cell cycle arrest, and inhibits CDK6 via miR-34a-5p. ZEN-3694 can be used in research related to HER2 breast cancer and metastatic castration-resistant prostate cancer .
Cat. No.: HY-P990964
CAS No.: 2765640-39-7
Synonyms: BOS-580; LLF580
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Cat. No.: HY-W011727S
CAS No.: 1354560-58-9
Synonyms: Pyridoxal 5'-phosphate-d3
Cat. No.: HY-178129
CAS No.: 1312534-69-2
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MRL-SYKi is a chemical probe for gain-of-function variants of spleen tyrosine kinase (SYK). MRL-SYKi reduces the catalytic activity of SYK S550Y, SYK S550F and SYK P342T, and downregulates the phosphorylation level of SYK S550Y. MRL-SYKi serves as a template for developing NanoBRET tracers targeting SYK, enabling NanoBRET cellular target engagement assays for gain-of-function variants of SYK. MRL-SYKi is applicable to research related to inflammatory and immune diseases .
Cat. No.: HY-D1845
CAS No.: 228272-69-3
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Cy3B is an improved variant of the Cy3 (Cyanine3) (HY-D0822) dye. Cy3 is a fluorescent dye, and its fluorescence spectrum generally falls within the green to orange wavelength range .
Cat. No.: HY-P99902
CAS No.: 1776942-10-9
Synonyms: FAP-IL2v; RO6874281; RG7461
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PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM .
Cat. No.: HY-P99498
CAS No.: 1509916-03-3
Synonyms: CEA-IL2v; RG 7813; RO 6895882
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DAUDA is a fluorescent fatty acid analog probe, with Kd values of 0.63 μM, 0.82 μM, and 0.66 μM against subtypes/mutants of Schistosoma mansoni Sm14 fatty acid-binding protein, respectively. DAUDA binds to Sm14 fatty acid-binding protein variants, enters their non-polar binding pockets and alters fluorescence emission properties. DAUDA serves as a tracer in competitive binding assays with natural fatty acids to evaluate the fatty acid-binding capacity of Sm14 protein variants. DAUDA is applicable to the research of schistosomiasis .
Synonyms: LEO-32731
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Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants .
Cat. No.: HY-P99786
CAS No.: 2096328-94-6
Synonyms: REGN3918
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Cat. No.: HY-P99962
CAS No.: 2342597-90-2
Synonyms: BGB-A425
Cat. No.: HY-P99811
CAS No.: 944548-37-2
Synonyms: CR57
Cat. No.: HY-W800809
CAS No.: 2768977-07-5
Cat. No.: HY-P3392
CAS No.: 2305355-56-8
Synonyms: ION373
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Zilganersen (ION373) is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen can be used for the research of Alexander disease .
Cat. No.: HY-P3392A
CAS No.: 2305355-64-8
Synonyms: ION373 sodium
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Zilganersen (ION373) sodium is a gapmer antisense oligonucleotide targeting glial fibrillary acidic protein (GFAP). Zilganersen sodium reduces excess glial fibrillary acidic protein produced by disease-causing variants in the GFAP gene and inhibits synthesis of GFAP. Zilganersen sodium can be used for the research of Alexander disease .
Cat. No.: HY-177650
Synonyms: ALN-TTRsc04
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Nucresiran is a siRNA that inhibits hepatic synthesis of both wild-type and variant TTR mRNA.
Cat. No.: HY-139582
CAS No.: 753015-44-0
Synonyms: OC-02
Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 µM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
