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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
METH-induced hyperactivity
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "METH-induced hyperactivity" in MCE Product Catalog:
Target:
Art. -Nr.: HY-108346
CAS. Nr.: 349087-34-9
Target:
Forschungsgebiete:
JX401 is a potent inhibitor of p38alpha, containing a 4-benzylpiperidine motif. p38alpha is hyperactive in inflammatory diseases, and various indications suggest that its inhibition would reverse inflammation. JX401 has the potential for the research of inflammation .
Art. -Nr.: HY-147529
CAS. Nr.: 1004614-58-7
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Forschungsgebiete:
mGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice .
Art. -Nr.: HY-121313
CAS. Nr.: 156001-18-2
Synonyms: BAY 10-6734
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Forschungsgebiete:
Embusartan (BAY 10-6734) is a brain-penetrant and effective AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension .
Art. -Nr.: HY-144070A
CAS. Nr.: 2768139-73-5
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Forschungsgebiete:
(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1) .
Art. -Nr.: HY-14824A
CAS. Nr.: 876170-44-4
Synonyms: ABT 894 benzenesulfonate
Target:
Forschungsgebiete:
Sofinicline benzenesulfonate (ABT 894 benzenesulfonate) is a novel nicotinic acetylcholine receptor agonist, specifically acting on the α4β2 subtype of nAChR (IC50=0.1 nM). Sofinicline benzenesulfonate has the potential to improve cognitive function, including attention, memory and working memory. Sofinicline benzenesulfonate can be used in studies of attention deficit, hyperactivity disorder (ADHD) .
Art. -Nr.: HY-108515
Reinheit: ≥99.0%
Synonyms: (R)-JO 1784 hydrochloride
Target:
Forschungsgebiete:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
(+)-Igmesine hydrochloride (JO1784) is an orally active and selective σ1 receptor ligand with an IC50 of 39 nM. (+)-Igmesine hydrochloride binds σ1 receptors to activate G-proteins and modulate Ca 2+ uptake. (+)-Igmesine (hydrochloride) attenuates ischaemia-induced nitric oxide synthase activity and hyperactivity. (+)-Igmesine hydrochloride can be used for the research of duodenal ulcers, gastric ulcers, and cerebral ischaemia .
Art. -Nr.: HY-17385R
CAS. Nr.: 82248-59-7
Synonyms: Tomoxetine hydrochloride (Standard); (R)-Tomoxetine hydrochloride (Standard); LY 139603 (Standard)
Forschungsgebiete:
Atomoxetine (hydrochloride) (Standard) is the analytical standard of Atomoxetine (hydrochloride). This product is intended for research and analytical applications. Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research .
Art. -Nr.: HY-N1990R
CAS. Nr.: 94987-08-3
Category:
Triterpenes Terpenoids Cucurbitaceae Extract Plants Gynostemma pentaphyllum (Thunb.) Makino
Target:
Art. -Nr.: HY-W027751R
CAS. Nr.: 578-58-5
Target:
Forschungsgebiete:
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
Art. -Nr.: HY-13458R
CAS. Nr.: 23651-95-8
Synonyms: L-DOPS (Standard); DOPS (Standard); SM5688 (Standard)
Forschungsgebiete:
Droxidopa (Standard) is the analytical standard of Droxidopa. This product is intended for research and analytical applications. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
Art. -Nr.: HY-13458S2
CAS. Nr.: 1261397-37-8
Synonyms: L-DOPS-13C6; DOPS-13C6; SM5688-13C6
Art. -Nr.: HY-N5159
CAS. Nr.: 197960-94-4
Category:
Target:
Art. -Nr.: HY-156532A
CAS. Nr.: 2104810-17-3
Target:
Forschungsgebiete:
5-HT2C agonist-3 ((+)-19) free base is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM). 5-HT2C agonist-3 free base has antipsychotic drug-like activity. 5-HT2C agonist-3 free base blocks Amphetamine-induced hyperactivity .
Art. -Nr.: HY-17416AS1
Art. -Nr.: HY-17416S2
Art. -Nr.: HY-107370S
CAS. Nr.: 919104-07-7
Synonyms: Tomoxetine-d7; (R)-Tomoxetine-d7
Art. -Nr.: HY-107370S1
CAS. Nr.: 1129478-03-0
Synonyms: Tomoxetine-d5; (R)-Tomoxetine-d5
Synonyms: GT-2331 maleate
Target:
Forschungsgebiete:
Cipralisant (GT-2331) (maleate) is an orally active, low-toxicity, potent, selective, high affinity histamine H3 receptor full antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant (maleate) has the potential for attention-deficit hyperactivity disorder research . Cipralisant (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Art. -Nr.: HY-111136
CAS. Nr.: 916898-61-8
Forschungsgebiete:
BL-1020 mesylate is the mesylate salt form of BL-1020. BL-1020 mesylate is an antipsychotic agent. BL-1020 mesylate is inhibitor for dopamine receptor and serotonin receptor (5-HT receptor), with Ki of 0.066, 0.062 and 0.21 nM, for D2L, D2S and 5-HT2A receptors, respectively. BL-1020 mesylate is agonist for GABAA receptor with Ki of 3.74 μM, and enhances the GABA release. BL-1020 mesylate exhibits high affinity with histamine receptor (Ki is 0.47 nM). BL-1020 mesylate reduces Amphetamine-induced hyperactivity, with lower catalepsy and sedation. BL-1020 mesylate is blood-brain barrier penetrate .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
