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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
85 Results for "
oATP
" in MedChemExpress (MCE) Product Catalog:
Products (85)
85 Results for "oATP" in MCE Product Catalog:
Cat. No.: HY-N15726
CAS No.: 2414481-40-4
Category:
Caesalpiniaceae Extract Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Saccharides Monosaccharides
Target:
Synonyms: CP-358774-d6 hydrochloride; NSC 718781-d6 hydrochloride; OSI-774-d6 hydrochloride
Cat. No.: HY-50896S1
CAS No.: 1211107-68-4
Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
Cat. No.: HY-50896S2
CAS No.: 1130852-41-3
Synonyms: CP-358774-d4; NSC 718781-d4; OSI-774-d4
Cat. No.: HY-50896S3
CAS No.: 1266656-97-6
Synonyms: CP-358774-d8; NSC 718781-d8; OSI-774-d8
Cat. No.: HY-16278R
CAS No.: 956136-95-1
Synonyms: LCQ-908 (Standard)
Target:
Research Areas:
Pradigastat (Standard) is the analytical standard of Pradigastat. This product is intended for research and analytical applications. Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 µM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 µM, 1.66µM, 3.34µM and 0.973µM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro .
Cat. No.: HY-161821
Target:
Research Areas:
Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety .
Cat. No.: HY-163146
Target:
Research Areas:
TME-HYM (PH Probe) is a novel fluorescent probe based on acidic tumor microenvironment (TME) activation and organic anion transporting polypeptide (OATPs, overexpressed on cancer cells), and can be selective uptaken. TME-HYM (PH Probe) can selectively lit up cancer cells and tumor tissues, offering dual tumor selectivity for precise visualization of tumor mass .
Cat. No.: HY-173231
CAS No.: 1402818-99-8
Target:
Research Areas:
hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. hURAT1 inhibitor 2 also has a certain inhibitory effect on OATP1B1, with an IC50 value of 0.73 μM. hURAT1 inhibitor 2 can be used in the research of diseases related to abnormal uric acid metabolism, such as hyperuricemia and gout .
Cat. No.: HY-155062
Research Areas:
IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARγ, and then inhibiting the β-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis .
Cat. No.: HY-B0396R
CAS No.: 161715-24-8
Synonyms: L084 (Standard)
Target:
Research Areas:
Tebipenem pivoxil (Standard) (L084 (Standard)) is the analytical standard of Tebipenem pivoxil (HY-B0396). This product is intended for research and analytical applications. Tebipenem pivoxil (L084 hydrobromide) is an orally active carbapenem Antibiotic. Tebipenem pivoxil acts as a substrate of OATP1A2 with high affinity for this transporter (Km = 41.1 μM) . Tebipenem pivoxil achieves intestinal absorption via carrier-mediated uptake and simple diffusion. Tebipenem pivoxil inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, multidrug-resistant bacteria, and pathogens producing extended-spectrum β-lactamases. Tebipenem pivoxil eliminates intestinal infection pathogens and reduces mortality in septic mice. Tebipenem pivoxil can be used in research related to bacterial pneumonia, severe gastrointestinal infections, bacterial sepsis, complicated urinary tract infections, and acute pyelonephritis .
Cat. No.: HY-P810930
Synonyms: oATP, oATP1, oATP1A2, SLC21A3, SLCO1A2, Solute carrier organic anion transporter family member 1A2, oATP-A, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter, Solute carrier family 21 member 3, oATP-1
Cat. No.: HY-137888
CAS No.: 54970-91-1
Synonyms: oATP
Cat. No.: HY-P702019
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SLCO1A2; Organic Anion-Transporting Polypeptide 1; Prev. SLC21A3; oATP-1; oATP1A2; Solute Carrier Organic Anion Transporter Family, Member 1A2; oATP-A; Solute Carrier Organic Anion Transporter Family Member; oATP; Organic Anion Transporting Polypeptide A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-115292S
CAS No.: 2747915-76-8
Synonyms: Tenivastatin-d6 sodium; Simvastatin impurity A-d6 sodium
Cat. No.: HY-D3433
CAS No.: 222159-75-3
Synonyms: CDCSF
Target:
Research Areas:
5-Carboxy-2′,7′-dichlorosulfonefluorescein (CDCSF) is a fluorescein derivative-based fluorescent probe. 5-Carboxy-2′,7′-dichlorosulfonefluorescein serves as a fluorescent substrate for the organic anion transporting polypeptide OATP2B1, and is specifically recognized and transported into cells by OATP2B1 under acidic pH conditions, making it suitable for in vitro high-throughput screening of drug-drug interactions (DDI) and food-drug interactions (FDI) (Ex/Em = 485/535 nm) .
Cat. No.: HY-N15205
CAS No.: 159278-74-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
