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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
tRNA Synthetase
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "tRNA Synthetase" in MCE Product Catalog:
Cat. No.: HY-130718
CAS No.: 2408626-64-0
ThrRS-IN-1 (Compound 30d) is a threonyl-tRNA synthetase (ThrRS) inhibitor with an IC50 of 1.4 µM and a Kd of 1.36 µM against Salmonella enterica ThrRS (SeThrRS). ThrRS-IN-1 simultaneously targets the tRNA Thr and L-threonine binding pockets of ThrRS. ThrRS-IN-1 shows potent antibacterial activities .
Cat. No.: HY-146263
CAS No.: 3031483-23-2
ThrRS-IN-3 (compound 36j) is a highly potent threonyl-tRNA synthetase (ThrRS) inhibitor, with an IC50 value of 19 nM and a Kd of 34 nM for Salmonella enterica ThrRS. ThrRS-IN-3 has antibacterial activities .
Cat. No.: HY-W275220
CAS No.: 3241-03-0
Target:
Research Areas:
PEA-NBOMe hydrochloride (Compound 21) is a competitive phenylalanyl-tRNA synthetase (PRS) inhibitor (Ki=0.92 μM), which is found in Escherichia coli. PEA-NBOMe hydrochloride is promising for research of antibacterial or antiviral agents .
Cat. No.: HY-147878
CAS No.: 2448358-84-5
Antibacterial agent 111 (Compound 3) is an antibacterial agent with MIC values of 3.90 μg/mL and 0.49 μg/mL against B. cereus and K. pneumonia, respectively. Antibacterial agent 111 firmly binds with tyrosyl-tRNA synthetase residues .
Cat. No.: HY-P991156
CAS No.: 2994192-38-8
Target:
Research Areas:
Cat. No.: HY-124679A
CAS No.: 3075275-82-7
(R)-DS86760016 is the R-enantiomer of DS86760016 (HY-124679). DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa .
Cat. No.: HY-12479B
CAS No.: 1234563-15-5
Synonyms: GSK-2251052 (R-mandelate); AN 3365 (R-mandelate)
Target:
Research Areas:
Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research .
Cat. No.: HY-169810
CAS No.: 849658-87-3
Target:
Research Areas:
PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance .
Cat. No.: HY-159103
Target:
Research Areas:
LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota .
Cat. No.: HY-175305
CAS No.: 3052352-22-1
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .
Cat. No.: HY-161901
CAS No.: 1219395-86-4
Target:
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BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice .
Cat. No.: HY-163457
Target:
Research Areas:
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
Cat. No.: HY-172773
PAA-38 is a highly potent selective inhibitor targeting bacterial prolyl-tRNA synthetase (ProRS). PAA-38 againsts Pseudomonas aeruginosa ProRS (PaProRS) with a Kd value of 0.399 nM and an IC50 value of 4.97 nM. PAA-38 againsts human cytoplasmic ProRSs (HsProRS) with an IC50 value of 35.5 nM. PAA-38 demonstrates an in vitro antibacterial activity of minimum inhibitory concentration (MIC) = 4-8 μg/mL .
Cat. No.: HY-P74738
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NARS1; Asparaginyl-tRNA Synthetase; Prev. NARS; NEDMILEG; AsnRS; NEDMILG; Asparagine tRNA Ligase 1, Cytoplasmic; NRS; Asparagine--tRNA Ligase, Cytoplasmic; Asparaginyl-tRNA Synthetase 1; Asparaginyl-tRNA Synthetase, Cytoplasmic
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P70840
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KARS1; LysRS; Prev. KARS; KIAA0070; Prev. DFNB89; CMTRIB; Lysyl-tRNA Synthetase; DEAPLE; Lysine--tRNA Ligase; LEPID; KARS2; KRS; Lysine tRNA Ligase; Lysyl-tRNA Synthetase 1; Deafness, Autosomal Recessive 89
Species:
Human
Source:
HEK293
Cat. No.: HY-P71134
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: WARS1; Tryptophanyl-tRNA Synthetase 1; IFI53; WARS; IFP53; Tryptophan--tRNA Ligase, Cytoplasmic; Tryptophanyl-tRNA Synthetase; Tryptophan tRNA Ligase 1, Cytoplasmic; Interferon-Induced Protein 53; TrpRS; HWRS; Epididymis Secretory Sperm Binding Protein; T
Species:
Human
Source:
E. coli
Cat. No.: HY-P73540
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: WARS1; Tryptophanyl-tRNA Synthetase 1; IFI53; WARS; IFP53; Tryptophan--tRNA Ligase, Cytoplasmic; Tryptophanyl-tRNA Synthetase; Tryptophan tRNA Ligase 1, Cytoplasmic; Interferon-Induced Protein 53; TrpRS; HWRS; Epididymis Secretory Sperm Binding Protein; T
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
