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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
132 Results for "
chaperones
" in MedChemExpress (MCE) Product Catalog:
Products (132)
132 Results for "chaperones" in MCE Product Catalog:
Category:
Monophenols Mercurialis Phenols Plants Euphorbiaceae Extract
Cat. No.: HY-148215
CAS No.: 1253584-78-9
Hsp90-IN-17 is a Hsp90 inhibitor. Hsp90-IN-17 binds to the N-terminal ATP-binding pocket of Hsp90, inhibits its chaperone function, and induces the degradation of Hsp90 client proteins. Hsp90-IN-17 inhibits cancer cell proliferation. Hsp90-IN-17 can be used in the research of ovarian cancer .
Cat. No.: HY-153881
CAS No.: 2768099-51-8
KRAS G12C degrader-1 (compound 283) is a potent KRASG12C chaperone-mediated protein (CHAMP) degrader with DC50 < 100 nM. KRAS G12C degrader-1 binds to KRAS G12C and HSP90, inducing ubiquitination and proteasomal degradation of KRAS G12C. KRAS G12C degrader-1 can be used for research on KRAS G12C-mutant cancers .
Cat. No.: HY-157184
CAS No.: 2415078-34-9
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1-Deoxydihydroceramide is an endogenous chaperone lipid that binds underneath the antigen and pushes the antigen toward the TCR .
Cat. No.: HY-14829B
CAS No.: 919364-56-0
Synonyms: AT 2101; D-Isofagomine tartrate; Isofagomine tartrate
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Afegostat tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
Cat. No.: HY-14829H
CAS No.: 1084896-50-3
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Afegostat TFA is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity .
Cat. No.: HY-100127
CAS No.: 1222374-44-8
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ML247 is a non-inhibitory and selective small molecule chaperone of acid alpha glucosidase. ML247 can be used for the research of metabolic disease, such as Pompe disease .
Cat. No.: HY-P2930
CAS No.: 95076-93-0
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Peptidylprolyl isomerase is an enzyme that catalyzes the cis-trans isomerization of peptidylprolyl amino groups. Peptidylprolyl isomerase may be involved in cellulase modification. Peptidylprolyl isomerase also functions as a chaperone protein .
Cat. No.: HY-161427
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HSP90-IN-30 (compound 3e) inhibits HSP90 chaperone activity. HSP90-IN-30 inhibits the activity of HIF-1 transcriptional under hypoxia with an IC50 value of 2.16 μM .
Cat. No.: HY-E70615
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Protein Disulfide Isomerase, Human, an oxidoreductase, is a mainly endoplasmic reticulum (ER) resident protein. Protein Disulfide Isomerase, Human plays an important role in maintaining cellular homeostasis through thiol oxidation/reduction cycling, chaperone action, and isomerization of client proteins .
Cat. No.: HY-161102
[Ru(phen)2(xant)] hexafluorophosphate is an inducer of Autophagy. [Ru(phen)2(xant)] hexafluorophosphate eliminates CRC stem cells by targeting the chaperone Hsp90. [Ru(phen)2(xant)] hexafluorophosphate reduces cell migration and invasion .
Cat. No.: HY-D2360
CAS No.: 1220716-15-3
Cat. No.: HY-B1039R
CAS No.: 18683-91-5
Synonyms: NA-872 (Standard)
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Ambroxol (Standard) is the analytical standard of Ambroxol. This product is intended for research and analytical applications. Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .
Cat. No.: HY-115513
CAS No.: 1332879-51-2
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Pitstop 1 is a small molecule inhibitor with endocytosis-inhibiting activity. Pitstop 1 blocks the interaction of chaperones with the Krasin terminal domain in cells, thereby affecting the function of Krasin. Pitstop 1 exhibits superior biological activity in significantly inhibiting the effects of Krasin. Pitstop 1 acts as a dose that inhibits the entry of viruses and pathogens into cells and modulates cell signaling .
Cat. No.: HY-111244
CAS No.: 87302-58-7
DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1 .
Cat. No.: HY-W739944
CAS No.: 1246818-80-3
Synonyms: NA-872-d5
Cat. No.: HY-167827
CAS No.: 439588-33-7
Hsp90-IN-34 (compound HAM-1) is a compound that inhibits the Aha1-Hsp90 chaperone complex with a high affinity for Hsp90/Aha1 (KDapp=23.5 µM). Hsp90-IN-34 modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1 .
Cat. No.: HY-19796R
CAS No.: 246529-22-6
Synonyms: Aramchol (Standard); C20-FABAC (Standard)
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Cucurbitacin D (Standard) is the analytical standard of Cucurbitacin D. This product is intended for research and analytical applications. Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
