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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
104 Results for "
breakdown
" in MedChemExpress (MCE) Product Catalog:
Products (104)
104 Results for "breakdown" in MCE Product Catalog:
Cat. No.: HY-Y1422T
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Lipase, Porcine is an orally active triglyceride hydrolase and fat absorption enhancer. Lipase, Porcine catalyzes the breakdown of triglycerides into fatty acids, as well as the hydrolysis of triglycerides and other carboxylic acid esters. Lipase, Porcine increases the absorption coefficients of fats, proteins and carbohydrates. Lipase, Porcine can be used in studies related to exocrine pancreatic insufficiency and congenital pancreatic triglyceride lipase deficiency .
Cat. No.: HY-107852
CAS No.: 17040-19-6
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Demeton-S-methyl sulfone is an organophosphorus insecticide metabolite.Demeton-S-methyl sulfone serves as a substrate for metabolic breakdown.Demeton-S-methyl sulfone forms via oxidation of demeton S-methyl sulfoxide in sugar-beet cell suspension cultures.Demeton-S-methyl sulfone undergoes thioester bond cleavage, producing ethanethiols that convert into S-methylated compounds or S-glucosides .
Cat. No.: HY-182912
CAS No.: 2851986-77-9
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PLX-4104 is an orally active BRD4 molecular glue degrader with a DC50 of 2 nM. PLX-4104 selectively promotes BRD4 degradation via DCAF11 recruitment, triggering ubiquitination and proteasomal breakdown. PLX-4104 inhibits cancer cell proliferation. PLX-4104 induces complete regression of AML xenograft tumors. PLX-4104 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-113278R
CAS No.: 3063-05-6
Cat. No.: HY-181410
CAS No.: 3093642-41-9
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PROTAC EZH2 Degrader-41 is an EZH2-targeting PROTAC and cIAP E3 ubiquitin ligase recruiter. PROTAC EZH2 Degrader-41 induces EZH2 degradation via ubiquitination and proteasomal breakdown. PROTAC EZH2 Degrader-41 exerts antiproliferative effects in lymphoma cells. PROTAC EZH2 Degrader-41 can be used for the research of lymphoma .
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Trimedoxime dichloride (TMB-4 dichloride) is a blood-brain barrier-permeable cholinesterase reactivator . Trimedoxime dichloride reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime dichloride reduces mortality and prolongs survival time. Trimedoxime dichloride exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime dichloride can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning .
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N-Demethyl amiton oxalic is an irreversible cholinesterase (ChE) inhibitor. N-Demethyl amiton oxalic elicits low-level postganglionic neuronal firing in cat vesical parasympathetic ganglia by preventing the breakdown of endogenously released ChE. N-Demethyl amiton oxalic inhibits ChE activity in squid optic ganglia and induces hyperactivity, ink ejection, pigment changes, and death, with a rate of enzymatic detoxification much lower than that of DFP. N-Demethyl amiton oxalic can be used in studies related to the mechanisms of cholinergic transmission in parasympathetic ganglia and neurotoxicology .
Cat. No.: HY-185310A
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MKI-2 hydrochloride is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 hydrochloride induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 hydrochloride reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 hydrochloride inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 hydrochloride inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 hydrochloride can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-185310
CAS No.: 438204-56-9
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MKI-2 is a selective MASTL inhibitor with an IC50 of 37.44 nM. MKI-2 induces mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. MKI-2 reduces phospho-ENSA, total, phospho-c-Myc levels. MKI-2 inhibts cancer cells proliferation, migration and induces DNA damage. MKI-2 inhibits germinal vesicle breakdown in mouse oocytes. MKI-2 can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-107532R
CAS No.: 81117-35-3
Synonyms: NN-DNJ (Standard); Nonyl-DNJ (Standard)
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N-Nonyldeoxynojirimycin (Standard) is the analytical standard of N-Nonyldeoxynojirimycin (HY-107532). This product is intended for research and analytical applications. N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM). N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breaKdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci .
Cat. No.: HY-118760
CAS No.: 137031-56-2
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Litebamine is a phenanthrene alkaloid with antiplatelet activity. Litebamine potently targets arachidonic acid- and collagen-induced platelet aggregation, but shows no activity against thrombin-induced aggregation. Litebamine inhibits arachidonic acid- and collagen-induced ATP release and thromboxane B2 production in rabbit platelets, without altering cyclic AMP levels or phosphoinositide breakdown in rabbit platelets. Litebamine has no effect on platelet-activating factor- or U46619 (HY-108566)-induced aggregation, nor does it affect [ 3H] inositol monophosphate production in rabbit platelets induced by collagen, platelet-activating factor or thrombin .
Cat. No.: HY-N16715
CAS No.: 1607436-76-9
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Cat. No.: HY-DY2034
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Ruthenium Red Staining Solution (0.01%) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium Red Staining Solution (0.01%) strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium Red Staining Solution (0.01%) is a L-type calcium current (ICa) blocker. When using Ruthenium Red Staining Solution (0.01%) to stain plant tissue sections affected by pathogens, the breakdown of mucilaginous substances by the pathogens prevents them from taking up the stain, whereas the cell walls of healthy tissue stain red .
Cat. No.: HY-P2832B
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Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) belongs to the ligase family and can activate the breakdown of complex fatty acids. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) catalyzes the production of fatty acyl-CoA in a two-step process via an adenylate intermediate. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) catalyzes the pre-reaction of fatty acid β-oxidation and can also be incorporated into phospholipids. Acyl-coenzyme A Synthetase, Pseudomonas sp. (EC 6.2.1.3) protein is involved in regulating and promoting the transport of long-chain fatty acids in mammalian cells.
Cat. No.: HY-107737R
CAS No.: 18194-25-7
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine (Standard)
Cat. No.: HY-107737S
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine-d55
Cat. No.: HY-107737S2
CAS No.: 136565-60-1
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine-d46
Cat. No.: HY-107737S3
Synonyms: 1,2-Dilauroyl-sn-glycero-3-phosphocholine-d9
Cat. No.: HY-L189
352 compounds
Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases.
MCE designs a unique collection of 352 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.
Cat. No.: HY-L146
4,407 compounds
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc.
MCE designs a unique collection of 4,407 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
