Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
109 Results for "
SIRT2
" in MedChemExpress (MCE) Product Catalog:
Products (109)
109 Results for "SIRT2" in MCE Product Catalog:
Cat. No.: HY-136713
CAS No.: 143034-06-4
Target:
Research Areas:
Sirt1/2-IN-5 is a SIRT1/SIRT2 inhibitor with human SIRT1 IC50 0.3 μM and human SIRT2 IC50 values 1.2 μM and pIC50 5.82. Sirt1/2-IN-5 inhibits NAD +-dependent deacetylase activity of SIRT1 and SIRT2. Sirt1/2-IN-5 can be used for the research of cancer, neurodegenerative disease [2].
Cat. No.: HY-P85521A
Synonyms: FLJ35621; FLJ37491; NAD dependent deacetylase SIRTuin 2; NAD-dependent deacetylase SIRTuin-2; NAD-dependent protein deacetylase SIRTuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2, S. cerevisiae, homolog-loke 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; SIRTuin; silent mating type information regulation 2 homolog; 2; S.cerevisiae; SIRTuin 2; SIRTuin type 2; SIRTuin2.
Cat. No.: HY-P702906
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SIRT2; SIR2L2; Prev. SIR2L; SIRTuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2; NAD-Dependent Protein Defatty-Acylase SIRTuin-2; NAD-Dependent Deacetylase SIRTuin-2; NAD-Dependent Protein Deacetylase SIRTuin-2; Silent Informati
Species:
Human
Source:
E. coli
Cat. No.: HY-P703015
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SIRT2; SIR2L2; Prev. SIR2L; SIRTuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2; NAD-Dependent Protein Defatty-Acylase SIRTuin-2; NAD-Dependent Deacetylase SIRTuin-2; NAD-Dependent Protein Deacetylase SIRTuin-2; Silent Informati
Species:
Human
Source:
E. coli
Cat. No.: HY-P85521
Synonyms: FLJ35621; FLJ37491; NAD dependent deacetylase SIRTuin 2; NAD-dependent deacetylase SIRTuin-2; NAD-dependent protein deacetylase SIRTuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2, S. cerevisiae, homolog-loke 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; SIRTuin; silent mating type information regulation 2 homolog; 2; S.cerevisiae; SIRTuin 2; SIRTuin type 2; SIRTuin2.
Cat. No.: HY-101278R
CAS No.: 1429749-41-6
Target:
Research Areas:
Thiomyristoyl (Standard) is the analytical standard of Thiomyristoyl (HY-101278). This product is intended for research and analytical applications. Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM.
Cat. No.: HY-182412
CAS No.: 2375182-58-2
NH4-6 is a SIRT2 inhibitor with an IC50 of 0.032 μM against SIRT2 and an IC50 of 3 μM against SIRT1. NH4-6 inhibits the deacetylase activity of SIRT1. As a cytotoxic agent, NH4-6 reduces cancer cell viability, suppresses anchorage-independent growth of cancer cells, induces acetylation of α-tubulin, and promotes acetylation of p53. NH4-6 can be used in the research of breast cancer .
Cat. No.: HY-184534
CAS No.: 2098493-54-8
Target:
Research Areas:
N-(4-Azidobutyl)-2-chloroacetamide is a PROTAC linker that can be used for the synthesis of PROTACs, such as PROTAC Sirt2 Degrader-1 (HY-103636) .
Cat. No.: HY-101073R
CAS No.: 1105698-15-4
Target:
Research Areas:
Salermide (Standard) is the analytical standard of Salermide (HY-101073). This product is intended for research and analytical applications. Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death.
Cat. No.: HY-101465R
CAS No.: 330461-64-8
Target:
Research Areas:
AK-1 (Standard) is the analytical standard of AK-1 (HY-101465). This product is intended for research and analytical applications. AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM.
Cat. No.: HY-100578R
CAS No.: 304896-28-4
Target:
Research Areas:
AGK2 (Standard) is the analytical standard of AGK2 (HY-100578). This product is intended for research and analytical applications. AGK2 is a selective SIRT2 inhibitor with an IC50 of 3.5 μM. AGK2 inhibits SIRT1 and SIRT3 with IC50s of 30 and 91 μM, respectively.
Cat. No.: HY-108986R
CAS No.: 96969-83-4
Target:
Research Areas:
JFD00244 (Standard) is the analytical standard of JFD00244 (HY-108986). This product is intended for research and analytical applications. JFD00244 is a sirtuin 2 (SIRT2) inhibitor, with anti-tumor effect. JFD00244 is also a Nsp-16 inhibitor against SARS-CoV-2 [2].
Cat. No.: HY-133849
CAS No.: 849215-53-8
Aristoforin, a hypericin derivative, inhibits the activities of SIRT1 and SIRT2. Aristoforin induces G1 phase cell cycle arrest, scavenges hydroxyl free radicals, and exhibits protective activity against Fe 2+-induced DNA breakage. Aristoforin can be used in studies related to breast cancer and colon adenocarcinoma [2] .
Cat. No.: HY-153509
CAS No.: 1392810-44-4
Sirtuin-IN-1 (Compound 18) is a SIRT1/2 inhibitor (IC50s: 6.2 μM and 4.2μM for SIRT1 and SIRT2, respectively). Sirtuin-IN-1 induces G1 cell cycle arrest. Sirtuin-IN-1 exhibits potent anti-cancer activity against glioma .
Cat. No.: HY-185682
CAS No.: 1382354-26-8
NCO-141 is a selective SIRT2 inhibitor with an IC50 of 0.5 μM. NCO-141 induces cell apoptosis via caspase activation and mitochondrial superoxide anion production. NCO-141 induces cell autophagy by increasing LC3-II levels and autophagosome accumulation. NCO-141 is applicable to relevant research on leukemia .
Cat. No.: HY-W744757
CAS No.: 113950-01-9
Synonyms: Niacinamide-15N; Nicotinic acid amide-15N
Cat. No.: HY-B0150S4
Synonyms: Niacinamide-13C,15N; Nicotinic acid amide-13C,15N
Cat. No.: HY-15510S
Cat. No.: HY-183870
CAS No.: 1382354-18-8
Research Areas:
NCO-90 is a selective SIRT2 inhibitor with an IC50 of 1.0 μM. NCO-90 induces Apoptosis via Caspase activation and mitochondrial superoxide anion production, and also induces Autophagic cell death by increasing LC3-II levels and autophagosome accumulation. NCO-90 exhibits anticancer activity against leukemia. NCO-90 can be used in research related to acute lymphoblastic leukemia and acute myeloid leukemia [2].
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
