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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
137 Results for "
DYRK
" in MedChemExpress (MCE) Product Catalog:
Products (137)
137 Results for "DYRK" in MCE Product Catalog:
Cat. No.: HY-P701672
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: DYRK2; Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2; Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2; Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Ki
Species:
Human
Source:
E. coli
Cat. No.: HY-N17356
CAS No.: 57959-88-3
Target:
Cat. No.: HY-180574
CAS No.: 2619847-12-8
TSL2109 is an orally active and selective DYRK2 and CDK4/6 inhibitor with an IC50 value of 22 nM for DYRK2. TSL2109 exhibits high kinase selectivity over 93%. TSL2109 arrests cell cycle and induces apoptosis in virto. TSL2109 effectively overcomes Enzalutamide (HY-70002) resistance by suppressing tumor growth in vivo and virto. TSL2109 also shows CDK4/6 inhibitor resistance.TSL2109 demonstrates safety profile. TSL2109 can be used for prostate cancer research and breast cancer [1][2].
Cat. No.: HY-P705592
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DYRK1B; Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 1B; Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1B; Mirk Protein Kinase; MIRK; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1B; Minibrain-Related Kinase; D
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706035
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: DYRK2; Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase 2; Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2; Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 2; Dual Specificity Tyrosine-(Y)-Phosphorylation Regulated Ki
Species:
Human
Source:
Sf9 insect cells
Target:
Research Areas:
AnnH31 is a Dyrk1A inhibitor (IC50: 81 nM). AnnH31 also inhibits MAO-A with an IC50 of 3.2 μM. AnnH31 inhibits cell viability of HeLa, PC12 and SH-SY5Y cells .
Cat. No.: HY-N0737AR
CAS No.: 442-51-3
Synonyms: Telepathine (Standard)
Target:
Cat. No.: HY-183831
CAS No.: 3034312-19-8
GPS167 is a CLK kinase inhibitor that potently and selectively inhibits recombinant human CLK1, CLK2 and CLK4. By inhibiting CLK-mediated phosphorylation of SRSF10, GPS167 upregulates the protein-binding ability of CLK1 and CLK4 with SRSF10, downregulates oncogenic BCLAF1-L and upregulates tumor-suppressive BCLAF1-S, regulates alternative splicing of genes such as MDM2 and MDM4, stabilizes p53 protein and induces DNA damage, ultimately triggering tumor cell apoptosis. GPS167 can block the epithelial-mesenchymal transition process of tumors, activate intracellular double-stranded RNA-mediated antiviral immune responses, and produce synergistic cytotoxicity when combined with microtubule-targeting drugs. GPS167 can be used in research related to various cancers including colorectal cancer .
Target:
Research Areas:
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC50=55 nM) with180-fold selectivity verses DYRK2 (IC50=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455) .
Cat. No.: HY-N2892
CAS No.: 97399-91-2
Synonyms: Aristololactam A IIIa; Sch 546909
Category:
Fissistigma balansae (A. DC.) Merr. Antibiotics Plants Annonaceae Disease Research Anticancer Other Antibiotics
Target:
Cat. No.: HY-110052R
CAS No.: 934358-00-6
Target:
Research Areas:
TBCA (Standard) is the analytical standard of TBCA (HY-110052). This product is intended for research and analytical applications. TBCA is a highly selective CK2 (casein Kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other Kinases .
Research Areas:
KH-CB20, an E/Z mixture, is a potent and selective inhibitor of CLK1 and the closely related isoform CLK4, with an IC50 of 16.5 nM for CLK1. KH-CB20 can also inhibit DYRK1A (IC50=57.8 nM) and CLK3 (IC50=488 nM) .
Cat. No.: HY-152183
CAS No.: 1507367-37-4
Target:
Research Areas:
FINDY is a folding intermediate-selective inhibitor of DYRK1A. FINDY can inhibit Ser97 autophosphorylation with an IC50 value of 35 μM. FINDY can be used for the research of neurological disorder . FINDY is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-101298R
CAS No.: 57046-73-8
Target:
Research Areas:
Paprotrain (Standard) is the analytical standard of Paprotrain (HY-101298). This product is intended for research and analytical applications. Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research .
Cat. No.: HY-122665A
Purity: 98.01%
HTH-01-091 TFA is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 TFA also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 TFA can be uesd for breast cancer research .
Cat. No.: HY-144826
CAS No.: 2668297-70-7
Target:
Research Areas:
ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. ZDWX-25 possesses significant cytotoxic activities against SH-SY5Y and HL-7702 cells. ZDWX-25 can be used for researching alzheimer's disease .
Cat. No.: HY-N0737AG
CAS No.: 442-51-3
Synonyms: Telepathine (GMP)
Target:
Cat. No.: HY-181046
CAS No.: 2201083-51-2
Target:
Research Areas:
Multi-kinase-IN-14 is an orally active and blood-brain barrier-permeable multi-kinase inhibitor. Multi-kinase-IN-14 reduces the excessive phosphorylation of α-synuclein by inhibiting four kinases (ABL1, DYRK1A, GSK3β, and LRRK2) and stabilizing microtubules. Multi-kinase-IN-14 is applicable for research on neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease .
Cat. No.: HY-N12625
CAS No.: 1364123-68-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
