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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1299 Results for "
SARS-CoV 3CLPpro
" in MedChemExpress (MCE) Product Catalog:
Products (1299)
1299 Results for "SARS-CoV 3CLPpro" in MCE Product Catalog:
Cat. No.: HY-12502AR
CAS No.: 111011-76-8
Synonyms: NZ-105 hydrochloride monoethanolate (Standard); (±)-Efonidipine hydrochloride monoethanolate (Standard)
Research Areas:
Efonidipine (NZ-105) hydrochloride monoethanolate (Standard) is the analytical standard of Efonidipine hydrochloride monoethanolate (HY-12502AR). This product is intended for research and analytical applications. Efonidipine (NZ-105) hydrochloride monoethanolate is an orally active dual L-type and T-type calcium channel blocker (CCB) with IC50 values of 1.8 and 350 nM, respectively. Efonidipine hydrochloride monoethanolate inhibits SARS-CoV-2 main protease. Efonidipine hydrochloride monoethanolate modulates adrenal steroidogenesis by increasing the expression of steroidogenic acute regulatory protein (StAR), dbcAMP-or angiotensin II-induced StAR mRNA expression and DHEA-S production, while suppressing the biosynthesis of aldosterone and cortisol. Efonidipine hydrochloride monoethanolate reduces plasma aldosterone levels in vivo. Efonidipine hydrochloride monoethanolate improves cardiac function in heart failure models by inhibiting T-type calcium channels (via both tonic and use-dependent blockade), independently of blood pressure reduction. Efonidipine hydrochloride monoethanolate can be used for research in hypertension, heart failure, and disorders involving dysregulated steroid hormone synthesis [3] .
Cat. No.: HY-N0891R
CAS No.: 115810-12-3
Synonyms: Tubeimoside-B (Standard)
Category:
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Cat. No.: HY-L027
1,237 compounds
Viruses are much simpler organisms than bacteria, and they are made from protein substances and nucleic acid. Despite the fact that the exact mechanism of infection is extremely specific to each type of virus, the general scheme of infection can be represented in the following manner: A virus is absorbed at the surface of a host cell and then permeates through the membrane, where it releases nucleic acid from its protein protection. Then the viral nucleic acid begins to replicate, and transcription of the viral genome takes place either in the cytoplasm, or in the nucleus of the host cell. As a result of these events, a large amount of viral nucleic acid and protein are made to make new generations of virions. Therefore, one mechanism of action of antiviral drugs is to interfere with the ability of a virus to get into a target cell. A second mechanism of action is to target the processes that synthesize virus components after a virus invades a cell, such as nucleotide or nucleoside analogs.
MCE designs a unique collection of 1,237 anti-virus compounds that target several viruses, including SARS-CoV, HBV, HCV, HIV, HSV and Influenza Virus. It’s an effective tool for anti-virus drug discovery.
Cat. No.: HY-P703545
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Spike glycoprotein; S glycoprotein; E2; Peplomer protein; Spike protein S1; Spike protein S2; Spike protein S2'; S; 3
Species:
Virus
Source:
HEK293
Cat. No.: HY-P705084
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Spike; S protein; Spike glycoprotein; S glycoprotein; B.1.1.7; 20I/501Y.V1; VOC 202012/01
Species:
Virus
Source:
HEK293
Cat. No.: HY-138794G
CAS No.: 2417089-74-6
Synonyms: (-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide
Cat. No.: HY-N8693
CAS No.: 362472-81-9
Category:
Cat. No.: HY-108044R
CAS No.: 868273-90-9
Target:
Research Areas:
ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease .
Cat. No.: HY-179249
Research Areas:
Fluoroneplanocin A-8N (Compound 3a) is an inhibitor targeting SAH hydrolase (IC50 = 1.51 μM) and viral RNA polymerase. Fluoroneplanocin A-8N exhibits broad-spectrum anti-SARS-CoV-2 and dengue virus activity, with EC50 values of 12.2 and 37.4 μM respectively. Fluoroneplanocin A-8N has no cytotoxicity. Fluoroneplanocin A-8N can be used for anti-positive-strand viruses .
Cat. No.: HY-P703536
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase
Species:
Virus
Source:
E. coli
Cat. No.: HY-187208
METTL3-IN-14 is a METTL3 inhibitor with a target IC50 of 6.68 μM and target Kd of 8.7 μM. METTL3-IN-14 binds to the METTL3 active site, inhibits methyltransferase activity, and does not alter METTL3 mRNA or protein expression levels. METTL3-IN-14 acts as an antiviral agent, exerts anti-SARS-CoV-2 activity via non-METTL3 targets. METTL3-IN-14 can be used for the research of covid-19 .
Cat. No.: HY-P991501
Synonyms: HcHAb18
Cat. No.: HY-P703539
Synonyms: Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703534
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703535
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703537
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1a; ORF1a polyprotein; Severe acute respiratory syndrome coronavirus 2; 2019-nCoV; pp1a; Endonuclease; Hydrolase; Methyltransferase; Nuclease; Protease; RNA-binding; Thiol protease; Transferase
Species:
Virus
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
