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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1431 Results for "
fluorometric imaging plate reader
" in MedChemExpress (MCE) Product Catalog:
Products (1431)
1431 Results for "fluorometric imaging plate reader" in MCE Product Catalog:
Cat. No.: HY-D3073
CAS No.: 2477607-64-8
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DXB-NIR is a push-pull dioxaboron fluorescent probe with solvatochromic properties, featuring high fluorescence brightness, photostability, and a large two-photon absorption cross-section. DXB-NIR exhibits Ex/Em of 550/620–780 nm (with two-photon excitation at 930 nm). DXB-NIR quantifies local polarity via the intensity ratio I (>640)/I (<640) between the far-red channel (<640 nm) and the near-infrared channel (>640 nm), and it can simultaneously label the plasma membrane, endoplasmic reticulum, and lipid droplets in live cells. DXB-NIR monitors the increase in local polarity of various cell compartments under conditions of cholesterol depletion, starvation, and oxidative stress. DXB-NIR can be used for polarity imaging of biological membranes and lipid droplets, as well as studies related to cellular stress .
Cat. No.: HY-D3186
CAS No.: 2163840-29-5
Cat. No.: HY-D3377
CAS No.: 1616953-95-7
Synonyms: LysoRhoNox
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HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for detecting Fe 2+ (ferrous iron ions), with excitation/emission wavelengths of Ex/Em = 550/575 nm. HMRhoNox-M exists in a non-fluorescent spirocyclic closed conformation under physiological pH conditions. Fe 2+ triggers the deoxidation of its N-oxide group, shifting the equilibrium toward the fluorescent quinone-type (TMHMR) open conformation. HMRhoNox-M shows selectivity for Fe 2+ over other metal ions, as well as biologically relevant reactive oxygen species, reactive sulfur species, reactive nitrogen species and reducing agents. HMRhoNox-M can penetrate cell membranes and localize to lysosomes, enabling the imaging of intracellular Fe 2+ fluctuations, transferrin-mediated labile iron accumulation, and lysosomal Fe 2+ changes associated with ferroptosis .
Cat. No.: HY-D3391
Cat. No.: HY-D3418
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BOD-Tz-TMR is a fluorescent probe used for nitric oxide (NO) detection and atherosclerotic plaque imaging.BOD-Tz-TMR has a detection limit of 31 nM for NO. BOD-Tz-TMR functions via Förster resonance energy transfer (FRET) and bioorthogonal reactions, in which the tetrazine linker quenches fluorescence through the energy transfer to dark state (ETDS) mechanism. The interaction of BOD-Tz-TMR with NO triggers a ratiometric shift in fluorescence from BODIPY (Ex/Em: 488 nm/512 nm, green channel) to TMR (Em: 592 nm, red channel). BOD-Tz-TMR labels macrophages through a bioorthogonal reaction with BCN, enabling its targeted accumulation at atherosclerotic plaque sites to detect endogenous NO associated with lesion progression. BOD-Tz-TMR can be used in studies related to atherosclerosis .
Cat. No.: HY-D3428
CAS No.: 2863678-02-6
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Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
LJ-2P is an NIR-II small-molecule fluorescent probe with fibrin/fibrinogen affinity. LJ-2P can bind coagulation-related proteins and restrict dye molecular motion, thereby enhancing local fluorescence for high-contrast imaging of bleeding and blood clots in vivo. LJ-2P can also co-precipitate with Ca 2+ to form LJ-2P nanoparticles, significantly enhancing NIR-II luminescence through the precipitation-enhanced emission (PEE) mechanism. LJ-2P can be used for research on bleeding disorders and breast cancer. LJ-2P exhibits dual-modal emission properties (Ex/Em ≈740/945 nm or 740/1066 nm) .
Cat. No.: HY-D3614
CAS No.: 2890606-81-0
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ERβ-targeted NIR probe P5 is an ERβ-selective fluorescent probe that binds preferentially to ERβ over ERα, enabling near-infrared fluorescence imaging of ERβ in living cells and in vivo. ERβ-targeted NIR probe P5 supports measurement of ERβ diffusion coefficient via fluorescence recovery after photobleaching. ERβ-targeted NIR probe P5 shows low cytotoxicity across multiple cell types, preserves ERβ expression, accumulates at ERβ-overexpressing tumor sites in vivo, and exhibits minimal fluorescence fluctuation across varied pH and cellular analyte conditions. ERβ-targeted NIR probe P5 can be used for the research of prostate cancer .
Cat. No.: HY-N9459
CAS No.: 1078691-95-8
Synonyms: D-Glucosamine Hydrochloride
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Cat. No.: HY-P992275
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Cat. No.: HY-P992341
Cat. No.: HY-W244412
CAS No.: 133081-27-3
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2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride is an intermediate of a radionuclide molecular probe targeting the CD4 receptor. 2,5-Dioxopyrrolidin-1-yl 6-hydrazinylnicotinate hydrochloride serves as an imaging agent for heart transplant rejection. This CD4 probe is prepared by mixing leukocyte differentiation antigen 4 monoclonal antibody with a solution of 6-hydrazinylnicotinoyl succinimide ester hydrochloride, followed by extraction and reaction to obtain 6-hydrazinylnicotinate-leukocyte differentiation antigen 4 monoclonal antibody; this antibody is then mixed with N-tris (hydroxymethyl) glycine, stannous chloride and technetium for an oscillatory reaction. This CD4 probe exhibits high affinity for CD4 + T lymphocytes, along with the characteristics of high sensitivity and high specificity, enabling early diagnosis of acute rejection .
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .
Cat. No.: HY-181494
CAS No.: 3056070-96-0
FAPI-X5 is a fibroblast activation protein (FAP) inhibitor. FAPI-X5 binds to the FAP catalytic domain, forming hydrogen bonds with key active residues and engaging in π-π stacking to drive functional inhibition. FAPI-X5 exhibits albumin binding activity to prolong systemic circulation half-life. FAPI-X5 induces cytostatic effects on glioblastoma tumors, slowing tumor growth without regression. FAPI-X5, when labeled with 68Ga, acts as a PET tracer with rapid tumor uptake and high-contrast imaging in glioblastoma tumor-bearing mice. FAPI-X5, when labeled with 177Lu or 47Sc, functions as a targeted radionuclide agent with prolonged tumor retention. FAPI-X5 can be used for the research of glioblastoma .
Cat. No.: HY-D1737
Cat. No.: HY-D2745
CAS No.: 1638544-48-5
Cat. No.: HY-D3080
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CR-1 is a ratiometric photoacoustic (PA) probe for in-situ real-time imaging of Zn 2+ in deep living tissues. CR-1 is formed by coupling the near-infrared cyanine dye IR825 with the Zn 2+ ligand tris (2-pyridylmethyl) amine (TMPA). Upon binding to Zn 2+, the five N atoms on TMPA coordinate with Zn 2+, leading to double bond rearrangement of IR825 and attenuation of its π-electron conjugated system. The absorption peak of CR-1 blue-shifts from 710 nm to 532 nm, enabling quantitative detection of Zn 2+ via the PA532/PA710 ratio. Free CR-1 generates a strong PA signal at 710 nm, while CR-1 bound to Zn 2+ produces a strong PA signal at 532 nm .
Cat. No.: HY-D3090
CAS No.: 2757682-04-3
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NRLD is a lipid droplet-targeting solvatochromic fluorescent probe developed based on Nile Red (HY-D0718), which can target lipid droplets and sense the non-polar lipid microenvironment inside lipid droplets. NRLD exhibits superior lipid droplet-targeting selectivity compared to the parent Nile Red dye in HeLa cell imaging. NRLD achieves detection relying on the solvatochromic effect generated by excited-state charge transfer, and its emission wavelength shifts according to the local polarity changes of the microenvironment it locates in: the more compact and ordered the lipid packing and the lower the environmental polarity, the more blue-shifted the emission; the looser the lipid packing or the stronger the hydration and the higher the environmental polarity, the more red-shifted the emission. NRLD shows blue shift in the non-polar oil core of lipid droplets and red shift in high-polarity environments such as phosphate buffer .
Cat. No.: HY-W035399S
Cat. No.: HY-W035399S1
CAS No.: 2708340-91-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
