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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1605 Results for "
mRNA
" in MedChemExpress (MCE) Product Catalog:
Products (1605)
1605 Results for "mRNA" in MCE Product Catalog:
Cat. No.: HY-P70143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KLK10; Kallikrein 10 Protein 8; Prev. PRSSL1; Protease Serine-Like 1; NES1; Kallikrein-10; Normal Epithelial Cell-Specific 1; CDNA FLJ76060, Highly Similar To Homo Sapiens Kallikrein 10 (KLK10), Transcript Variant 1, mRNA; Kallikrein 10 Protein 12; Breast
Species:
Human
Source:
HEK293
Cat. No.: HY-P75296
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CLEC7A; CDNA FLJ59887, Moderately Similar To Homo Sapiens C-Type Lectin Domain Family 7, Member A (CLEC7A), Transcript Variant 4, mRNA; Prev. CLECSF12; C-Type Lectin Domain Containing 7A Transcript Variant 7; C-Type Lectin Domain Family 7 Member A; C-Type
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P85636
Synonyms: FADD; FADD protein; FADD_HUMAN; Fas; TNFRSF6; associated via death domain; Fas associated via death domain; Fas associating death domain containing protein; Fas associating death domain containing protein; Fas associating protein; Fas associating protein with death domain; Fas associating protein with death domain; Fas TNFRSF6 associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; FasTNFRSF6 associated via death domain; FasTNFRSF6 associated via death domain; GIG 3; GIG3; Growth inhibiting gene 3 protein; Growth-inhibiting gene 3 protein; H sapiens mRNA for mediator of receptor induced toxicity; H sapiens mRNA for mediator of receptor induced toxicity; Mediator of receptor induced toxicity; Mediator of receptor induced toxicity; MGC8528; MGC8528; MORT 1; MORT1; MORT1; Protein FADD.
Cat. No.: HY-13650R
CAS No.: 165668-41-7
Synonyms: E 7070 (Standard)
Research Areas:
Indisulam (Standard) (E 7070 (Standard)) is the analytical standard of Indisulam (HY-13650). This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor and RBM39 molecular glue degrader, with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, respectively, and a Ki value of 65 nM against bovine carbonic anhydrase IV. Indisulam promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39. Indisulam induces aberrant pre-mRNA splicing, G1 cell cycle arrest, and cell death in cancer cells. As an anticancer agent, Indisulam drives tumor regression and growth inhibition in xenograft models. Indisulam can be used in research related to solid tumors, hematologic and lymphoid malignancies, colorectal cancer, and non-small cell lung cancer .
Research Areas:
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
Cat. No.: HY-162362
CAS No.: 3060730-06-2
Target:
Research Areas:
MS8709 is a PROTAC degrader that induces the degradation of G9a (EHMT2)/GLP (EHMT1) by recruiting VHL. MS8709 induces G9a/GLP protein degradation via a mechanism that simultaneously depends on G9a/GLP target protein binding, VHL recruitment, and the ubiquitin-proteasome system (UPS), while the mRNA levels of G9a and GLP do not show significant changes, indicating that the effect occurs primarily at the protein level rather than the transcriptional level. MS8709 retains the inhibitory effect on G9a/GLP methyltransferase activity and reduces H3K9me2 levels, thereby simultaneously affecting the catalytic and non-catalytic functions of G9a/GLP. MS8709 can be used for studies related to G9a/GLP biology, prostate cancer, lung cancer, and other relevant fields .
Cat. No.: HY-179433
Research Areas:
PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS). PROTAC AR Degrader-12 induces AR degradation in a ubiquitin proteasome system (UPS) pathway-dependent manner. PROTAC AR Degrader-12 inhibits tumor cell growth by affecting DNA replication and cell division PROTAC AR Degrader-12 could not only effectively degrade AR, but also potently inhibit the proliferation of MCF-7 and multiple mutant or resistant BC cells. PROTAC AR Degrader-12 effectively blocked estrogen receptor α (ERα) signaling through a dual mechanism involving ERα protein downregulation and suppression of its transcriptional activity. PROTAC AR Degrader-12 significantly inhibits the mRNA expression of FOXA1, GREB1, SRC, and PELP1. PROTAC AR Degrader-12 can be used for the study of breast cancer .
Cat. No.: HY-P11698
CAS No.: 476667-31-9
Research Areas:
Cat. No.: HY-P5832
CAS No.: 836606-84-9
Target:
Research Areas:
Cat. No.: HY-P700399
Purity: Purity analysis by SDS-PAGE is not available for VLP proteins.
Synonyms: CCR4; CKR4; C-C Motif Chemokine Receptor 4; C-C Chemokine Receptor Type 4; CC-CKR-4; C-C CKR-4; CMKBR4; CCR-4; K5-5; CDNA FLJ75821, Highly Similar To Homo Sapiens Chemokine (C-C Motif) Receptor 4 (CCR4), mRNA; Chemokine (C-C Motif) Receptor 4; Chemokine (
Species:
Human
Source:
HEK293
Cat. No.: HY-P702606
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCR4; CKR4; C-C Motif Chemokine Receptor 4; C-C Chemokine Receptor Type 4; CC-CKR-4; C-C CKR-4; CMKBR4; CCR-4; K5-5; CDNA FLJ75821, Highly Similar To Homo Sapiens Chemokine (C-C Motif) Receptor 4 (CCR4), mRNA; Chemokine (C-C Motif) Receptor 4; Chemokine (
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-12502AR
CAS No.: 111011-76-8
Synonyms: NZ-105 hydrochloride monoethanolate (Standard); (±)-Efonidipine hydrochloride monoethanolate (Standard)
Research Areas:
Efonidipine (NZ-105) hydrochloride monoethanolate (Standard) is the analytical standard of Efonidipine hydrochloride monoethanolate (HY-12502AR). This product is intended for research and analytical applications. Efonidipine (NZ-105) hydrochloride monoethanolate is an orally active dual L-type and T-type calcium channel blocker (CCB) with IC50 values of 1.8 and 350 nM, respectively. Efonidipine hydrochloride monoethanolate inhibits SARS-CoV-2 main protease. Efonidipine hydrochloride monoethanolate modulates adrenal steroidogenesis by increasing the expression of steroidogenic acute regulatory protein (StAR), dbcAMP-or angiotensin II-induced StAR mRNA expression and DHEA-S production, while suppressing the biosynthesis of aldosterone and cortisol. Efonidipine hydrochloride monoethanolate reduces plasma aldosterone levels in vivo. Efonidipine hydrochloride monoethanolate improves cardiac function in heart failure models by inhibiting T-type calcium channels (via both tonic and use-dependent blockade), independently of blood pressure reduction. Efonidipine hydrochloride monoethanolate can be used for research in hypertension, heart failure, and disorders involving dysregulated steroid hormone synthesis .
Cat. No.: HY-165603
CAS No.: 3006860-57-4
Research Areas:
Si5-N14 is a key component of siloxane-incorporated lipid nanoparticles (SiLNP), possessing pro-vascular repair and anti-tumor activities. In the transgenic GFP mouse model, Si5-N14 can mediate CRISPR-Cas9 editing. In the Lewis lung carcinoma (LLC) tumor-bearing mouse model, Si5-N14 can knock out the expression of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) to exert an anti-tumor effect. In a mouse model of lung injury induced by viral infection, the delivery of Fibroblast Growth Factor-2 (FGF-2) mRNA via Si5-N14 can promote vascular repair, increase blood oxygen levels, and improve lung function. Si5-N14 shows promise for research in the fields of oncology, pneumonia, and cardiovascular diseases .
Cat. No.: HY-169859
CAS No.: 3035217-40-1
Research Areas:
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model .
Cat. No.: HY-189215
CAS No.: 3087067-85-1
Target:
Influenza Virus RIG-I-like receptor (RLR) Toll-like Receptor (TLR) NF-κB Interleukin Related IFNAR Apoptosis Reactive Oxygen Species (ROS)
Research Areas:
Anti-Influenza agent 12 is an orally active inhibitor of influenza A virus infection. Anti-Influenza agent 12 inhibits RIG-I-mediated innate immune signaling and TLR3-mediated signaling pathways. Anti-Influenza agent 12 inhibits NF-κB phosphorylation and downregulates the expression levels of IRF3, ASC, iNOS, IL-4, IL-6, and IFN-α inflammatory genes. Anti-Influenza agent 12 inhibits viral nucleoprotein (NP) and matrix protein 2 (M2) mRNA transcription and protein synthesis. Anti-Influenza agent 12 inhibits virus-induced apoptosis, reduces ROS and NO production, and maintains mitochondrial membrane potential. Anti-Influenza agent 12 exhibits broad-spectrum activity against H1N1 and H3N2 subtypes, reduces viral load, and alleviates lung tissue damage. Anti-Influenza agent 12 can be used for research on influenza A virus infection .
Cat. No.: HY-N10423
CAS No.: 18423-69-3
Synonyms: (-)-Cubebin
Cat. No.: HY-N2160
CAS No.: 77690-92-7
Cat. No.: HY-P701686
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FIP1L1; Rearranged In Hypereosinophilia; Factor Interacting With PAPOLA And CPSF1; Factor Interacting With PAP; HFip1; DKFZp586K0717; FIP1; FIP1 Like 1 (S. Cerevisiae); Pre-mRNA 3'-End-Processing Factor FIP1; FIP1 Like 1; FIP1-Like 1 Protein; Rhe; FIP1L1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P70909A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MAP1LC3B; CDNA FLJ77661, Highly Similar To Homo Sapiens Microtubule-Associated Protein 1 Light Chain 3 Beta(MAP1LC3B), mRNA; Microtubule Associated Protein 1 Light Chain 3 Beta; Microtubule-Associated Protein 1 Light Chain 3 Beta, Isoform CRA_b; ATG8F; Mi
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
