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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
265 Results for "
Folate
" in MedChemExpress (MCE) Product Catalog:
Products (265)
265 Results for "Folate" in MCE Product Catalog:
Cat. No.: HY-128937
CAS No.: 1602487-15-9
Target:
연구분야:
EC1454 is a peptide compound with anticancer activity that targets folate receptor-expressing cancers. EC1454 is a folate-tubulysin conjugate that can be used to prepare drug delivery conjugates for targeted therapy .
연구분야:
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions .
Target:
연구분야:
Glutamate carboxypeptidase is an endo/exopeptidase targeting folate and antifolate agents. Glutamate carboxypeptidase regulates intracellular folate homeostasis by hydrolyzing γ-polyglutamate chains. Glutamate carboxypeptidase is promising for research of antifolate agents and cancers .
Cat. No.: HY-P77936
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IZUMO1R; Folate Receptor Delta; Prev. FOLR4; Folate Receptor 4 (Delta) Homolog (Mouse); JUNO; Folate Receptor 4 (Delta) Homolog; Folbp3; IZUMO1 Receptor, JUNO, FR-Delta; Folate Receptor 4, Delta (Putative); Probable Folate Receptor Delta; Sperm-Egg Fusion
Species:
Human
Source:
HEK293
Cat. No.: HY-P77938
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: IZUMO1R; Folate Receptor Delta; Prev. FOLR4; Folate Receptor 4 (Delta) Homolog (Mouse); JUNO; Folate Receptor 4 (Delta) Homolog; Folbp3; IZUMO1 Receptor, JUNO, FR-Delta; Folate Receptor 4, Delta (Putative); Probable Folate Receptor Delta; Sperm-Egg Fusion
Species:
Mouse
Source:
HEK293
Cat. No.: HY-180461
CAS No.: 1402547-47-0
Target:
연구분야:
EET analog 7 is an epoxyeicosatrienoic acid (EET) analog that can be conjugated with folate receptor ligands to target kidney cells expressing high levels of folate receptors. EET analog 7 can be used for constructing kidney-targeted drug conjugates .
Cat. No.: HY-188043
CAS No.: 926623-28-1
Synonyms: Pte-Cys-ss-DAVLBH
Target:
연구분야:
EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins .
Cat. No.: HY-124350R
CAS No.: 134-05-4
10-Formylfolic acid (Standard) is the analytical standard of 10-Formylfolic acid (HY-124350). This product is intended for research and analytical applications. 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions .
Cat. No.: HY-124350S
CAS No.: 461426-41-5
10-Formylfolic acid-d4 is the deuterated-labeled 10-Formylfolic acid (HY-124350). 10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase, with an IC50 of 80 nM against the rat enzyme. 10-Formylfolic acid also acts as an orally active folate source and a growth factor for specific bacteria. 10-Formylfolic acid supports growth and increases plasma folate levels; its absorption and metabolism patterns are similar to those of folic acid, but its liver retention is slightly higher. It exhibits high folate activity in microbial assays, serves as a growth factor for Enterococcus faecalis and Lactobacillus casei, aids folate nutrient supply, and may exert cell regulatory functions .
Cat. No.: HY-121927
CAS No.: 238074-89-0
Synonyms: CH-1504
연구분야:
Mobiletrex is an anti folate and dihydrofolate reductase inhibitor that can be used in research on rheumatoid arthritis .
Cat. No.: HY-129880
CAS No.: 55383-37-4
Synonyms: Deacetylvinblastine hydrazide; DAVLBH
Target:
연구분야:
Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor .
Category:
Target:
Cat. No.: HY-128939
CAS No.: 1059477-92-7
Target:
연구분야:
EC0488 is used to synthesize EC0531 with folate receptor (FR)-specific and anti-tumor activities .
Cat. No.: HY-113046S
Purity: ≥98.0%
Synonyms: 5-Methyl THF-13C5; 5-MTHF-13C,d5
Cat. No.: HY-128940
CAS No.: 625827-91-0
Target:
연구분야:
EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1 .
Cat. No.: HY-126830
CAS No.: 1286279-90-0
Target:
연구분야:
Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed .
Synonyms: Methotrexate 5-methyl ester; γ-EMTX
Target:
연구분야:
Methotrexate γ-Methyl Ester (Methotrexate 5-methyl ester) is an impurity of the folate antagonist Methotrexate (HY-14519) .
Target:
연구분야:
Pteropterin (Pteroyltriglutamic) is an active form of folate. Pteropterin shows inhibiting effect on tumor growth and has broad anticancer activity .
Cat. No.: HY-127118A
CAS No.: 6164-84-7
Synonyms: Pteroyltriglutamic monohydrate
Target:
연구분야:
Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
