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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
265 Results for "
Folate
" in MedChemExpress (MCE) Product Catalog:
Products (265)
265 Results for "Folate" in MCE Product Catalog:
Cat. No.: HY-180557
Target:
Research Areas:
4A-BFA-11 is a folate-targeted PEG-MMAE conjugate that exhibits specific binding affinity for the folate receptor α (FR-α) (KD = 106.7 nM). 4A-BFA-11 achieves tumor enrichment by combining PEG-mediated long circulation (EPR effect) and folate receptor targeting. 4A-BFA-11 undergoes enzymatic cleavage at the tumor site to release the active payload, enabling precise action. 4A-BFA-11 sefficiently carries, targets, and controls the release of MMAE in tumor tissues in a HeLa mouse model. 4A-BFA-11 can be used for cervical cancer, ovarian cancer, and lung cancer research .
Synonyms: ZD 9331; BGC9331
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Research Areas:
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent thymidylate synthase (TS) inhibitor with a Ki of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Dihydrofolate reductase is a key enzyme in folate metabolism and, therefore, in the production of thymidine. Its role in thymidine biosynthesis is the reduction of dihydrofolate to tetrahydrofolate using the cofactor NADPH .
Cat. No.: HY-124093
CAS No.: 111113-73-6
Target:
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX (HY-14519) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors .
Cat. No.: HY-D2523
Cat. No.: HY-P705625
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC19A1; Cyclic Dinucleotide:Anion Antiporter SLC19A1; Solute Carrier Family 19 Member 1; Reduced Folate Carrier Protein; IFC-1; Placental Folate Transporter; RFT-1; Reduced Folate Carrier 1; FOLT; Folate Transporter 1; RFC1; HSLC19A1; HRFC; SLC19A1 Prote
Species:
Human
Source:
HEK293
Cat. No.: HY-W007692
CAS No.: 22047-25-2
Synonyms: 2-Acetylpyrazine
Target:
Research Areas:
Acetylpyrazine (2-Acetylpyrazine) is used to form many polycyclic compounds, as useful structures in pharmaceuticals and perfumes. Acetylpyrazine is a component of the folates (vitamin B compounds) .
Cat. No.: HY-B1008S
CAS No.: 350820-01-8
Synonyms: PABA-d4; Vitamin Bx-d4; Vitamin H1-d4; p-Aminobenzoic acid-d4
Cat. No.: HY-137267
CAS No.: 80576-77-8
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10-Methyl-10-deazaaminopterin is a folate analog and an antifolate. 10-Methyl-10-deazaaminopterin can be used for the research of cancer .
Cat. No.: HY-P11024
CAS No.: 2852679-40-2
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Research Areas:
Cat. No.: HY-13616
CAS No.: 479578-27-3
Synonyms: EC 20
Research Areas:
Etarfolatide (EC 20) is a valuable noninvasive imaging agent. Etarfolatide identifies folate receptor expression. Etarfolatide can be used in research on ovarian cancer and disease diagnosis after being radiolabeled .
Cat. No.: HY-P2631
CAS No.: 742091-99-2
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Research Areas:
Cat. No.: HY-126733
CAS No.: 73951-54-9
Synonyms: (6R)-Folinic acid
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Research Areas:
(6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate .
Cat. No.: HY-10822
CAS No.: 501332-69-0
Synonyms: BGC 945; ONX-0801; CB 300945
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Research Areas:
Idetrexed (ONX 0801) is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .
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Research Areas:
Tetrahydromethotrexate is a more potent folate antagonist than Methotrexate (HY-14519) in studies against certain bacteria (Streptococcus faecalis, Pediococcus erevisiae) and in animal models. Tetrahydromethotrexate is used in the research of cancer and autoimmune diseases .
Cat. No.: HY-176247
CAS No.: 2995300-60-0
DHFS-IN-1 (Compound 3) is a dihydrofolate synthetase (DHFS) inhibitor with an IC50 value of 2.6 μM. DHFS-IN-1 can be used in research on infectious diseases related to bacterial folate synthesis .
Cat. No.: HY-10822A
CAS No.: 1097638-00-0
Synonyms: BGC 945 trisodium; ONX 0801 trisodium; CB 300945 trisodium
Target:
Research Areas:
Idetrexed (ONX 0801) trisodium is a thymidylate synthase (TS) inhibitor with a Ki of 1.2 nM. Idetrexed trisodium can be specifically transported into α-folate receptor (α-FR)-overexpressing tumors, such as ovarian cancer .
Cat. No.: HY-122518
CAS No.: 51989-25-4
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Research Areas:
8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice .
Cat. No.: HY-W713855
CAS No.: 5959-18-2
Target:
Research Areas:
(4-Aminobenzoyl)-D-glutamic acid (Compound 17) exhibits competitive inhibitory activity against H2-pteroate synthesis system, which affects the synthesis of folate, thereby inhibiting growth of bacteria .
Cat. No.: HY-147699
CAS No.: 2028296-64-0
Target:
Research Areas:
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
