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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
217 Results for "
macrocyclic
" in MedChemExpress (MCE) Product Catalog:
Products (217)
217 Results for "macrocyclic" in MCE Product Catalog:
Cat. No.: HY-107212R
CAS No.: 220119-17-5
Research Areas:
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM .
Cat. No.: HY-107486R
CAS No.: 56377-79-8
Synonyms: Multhiomycin (Standard); RP 9671 (Standard)
Category:
Microorganisms Antibiotics Animal Husbandry Disease Research Antibacterial Other Antibiotics
Target:
Cat. No.: HY-156038B
Target:
Research Areas:
(S)-p-SCN-Bn-DOTA TFA is a bifunctional chelator (BFC), a macrocyclic DOTA (HY-W053583) derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA TFA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies .
Cat. No.: HY-161370
CAS No.: 2574390-19-3
Target:
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VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC50 = 3.7 nM), HGFA(IC50 = 3.3 nM), matriptase (IC50 = 2.9 nM), and hepsin (IC50 = 0.54 nM). VD4162 can be used for the research of cancer .
Cat. No.: HY-17580S
CAS No.: 2143934-06-7
Cat. No.: HY-186323
Target:
Research Areas:
1,2,3,5,6,7-Hexahydro-s-indacen-4-amine-succinic acid is an orally active macrocyclic octapeptide PCSK9 inhibitor. 1,2,3,5,6,7-Hexahydro-s-indacen-4-amine-succinic acid can be used for the research of atherosclerotic cardiovascular disease .
Cat. No.: HY-N10360
Target:
Cat. No.: HY-P10477
CAS No.: 1000770-96-6
Target:
Research Areas:
Cat. No.: HY-W127809
CAS No.: 550-52-7
Cat. No.: HY-164732
CAS No.: 1611478-62-6
Target:
Research Areas:
Fmoc-Lys (DOTA)-OH is an Fmoc-protected Lysine derivative with metal-chelating properties, containing the macrocyclic chelator DOTA. Fmoc-Lys (DOTA)-OH undergoes metallation with Tb or Lu. Fmoc-Lys (DOTA)-OH utilizes metal coordination to protect the carboxyl groups of DOTA. Fmoc-Lys (DOTA)-OH can be used in solid-phase peptide synthesis research .
Cat. No.: HY-187882
CAS No.: 3079099-31-0
Synonyms: PAS-004
Nuvrumetinib (PAS-004) is a macrocyclic MEK inhibitor. Nuvrumetinib functionally inhibits MEK1/2, thereby suppressing pERK in tumors. Nuvrumetinib inhibits the proliferation of NRAS-mutant cancer cells. Nuvrumetinib can be used in studies related to NRAS G12C-mutant solid tumors, neurofibromatosis type 1 (NF1), RASopathies and laminopathies .
Cat. No.: HY-N6686R
CAS No.: 21411-53-0
Synonyms: Pristinamycin IIA (Standard); Ostreogrycin A (Standard)
Target:
Cat. No.: HY-P3313
CAS No.: 155547-93-6
Category:
Target:
Cat. No.: HY-115516
CAS No.: 1309952-03-1
Target:
Research Areas:
BI-1388 is a macrocyclic acylsulfonamide-based HCV NS3-4A protease inhibitor. BI-1388 inhibits clinically relevant drug-resistant mutant strains (KRAS D168V gt 1b and KRAS R155K gt 1a) and exhibits high liver distribution. BI-1388 is applicable for the research of HCV infection .
Cat. No.: HY-144617
CAS No.: 2426628-29-5
JH-XIV-68-3 is a selective macrocyclic inhibitor of DYRK1A/B. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines .
Cat. No.: HY-182588
CAS No.: 20905-50-4
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Research Areas:
Circulin B is a macrocyclic plant cyclopeptide. Circulin B functions as a plant defense peptide and exhibits antibacterial and anti-HIV activities. Circulin B has high binding affinity for the envelope protein of dengue virus, showing potential anti-dengue virus activity. Circulin B can be used in studies related to dengue virus infection, human immunodeficiency virus infection and microbial infection .
Cat. No.: HY-P10855
CAS No.: 3027437-21-1
Cat. No.: HY-13756S2
Synonyms: FK506-d3; Fujimycin-d3; FR900506-d3
Cat. No.: HY-17580R
CAS No.: 873857-62-6
Synonyms: OPT-80 (Standard); PAR-101 (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
