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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2419 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2419)
2419 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-B0579S3
Synonyms: Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4; CsA-13C2,d4
Cat. No.: HY-B0852R
CAS No.: 107534-96-3
Research Areas:
Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells .
Cat. No.: HY-B0852S2
Cat. No.: HY-B1455S1
CAS No.: 2140264-63-5
Synonyms: 4,4'-DDD (Standard); p,p'-Dichlorodiphenyl dichloroethane (Standard)
Research Areas:
p,p'-DDD (Standard) is the analytical standard of p,p'-DDD (HY-B1984) . This product is intended for research and analytical applications. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.
Cat. No.: HY-B1984S
CAS No.: 93952-20-6
Synonyms: 4,4'-DDD-d8; p,p'-Dichlorodiphenyl dichloroethane-d8
Cat. No.: HY-D0877
CAS No.: 29915-38-6
Cat. No.: HY-N0046
CAS No.: 88105-29-7
Synonyms: Notoginseng triterpenes; Ginsenoside Mb
Cat. No.: HY-N0433R
CAS No.: 84676-89-1
Synonyms: Astrasieversianin VIII (Standard)
Synonyms: NSC 3778 (Standard); O-Methylsalicylic acid (Standard); Salicylic acid methyl ether (Standard)
Cat. No.: HY-N14780
CAS No.: 544712-82-5
Synonyms: (+)-Pochonin D
Category:
Cat. No.: HY-N17963
CAS No.: 229483-41-4
Cat. No.: HY-N6682R
CAS No.: 22144-77-0
Synonyms: Zygosporin A (Standard); NSC 209835 (Standard)
Category:
Cat. No.: HY-N6801S
CAS No.: 911392-40-0
Cat. No.: HY-N6896R
CAS No.: 40788-84-9
Cat. No.: HY-N7801
CAS No.: 83952-40-3
Category:
Target:
Cat. No.: HY-P11489
CAS No.: 252731-57-0
Research Areas:
RN-0001 is an inhibitor of Calcineurin and cyclophilin (Cyp), with Ki values of 4.1 nM and 12.0 nM against CypA and CypD, respectively, and an EC50 of 916 nM for CypD. RN-0001 binds directly to CypD, inhibits the peptidyl-prolyl cis-trans isomerase activities of CypD and CypA, and prevents CypD-dependent mitochondrial permeability transition pore opening. RN-0001 improves mitochondrial function, reduces ROS production, inhibits the expression of lipogenic markers, blocks the nuclear translocation of NF-κB p65, and decreases the release of activated caspase-3 and cytochrome c. RN-0001 can be used in the research of alcohol-associated liver disease .
Cat. No.: HY-P4882A
Target:
Research Areas:
(Pyr3)-Amyloid β-Protein (3-42) TFA is an N-terminally truncated and pyroglutamate-modified amyloid β peptide. (Pyr3)-Amyloid β-Protein (3-42) TFA spontaneously aggregates into soluble oligomers and β-sheet-structured fibrils, causing neuronal cytotoxicity and leading to decreased expression of postsynaptic density protein 95 (PSD-95) in mouse cortex, thereby inducing synaptic dysfunction in spatial and short-term memory. (Pyr3)-Amyloid β-Protein (3-42) TFA can be used for research on Alzheimer's disease .
Cat. No.: HY-W002942
CAS No.: 6640-50-2
Synonyms: 1,2,3,4-Tetrahydroquinolin-8-ol; 8-hydroxy-1,2,3,4-tetrahydroquinoline
Research Areas:
Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal I/R injury by suppressing ferroptosis and directly scavenging peroxyl radicals. Ferroptosis-IN-21 displays broad-spectrum anti-ferroptotic efficacy across multiple inducers in renal tubular epithelial cells, with nanomolar potency and robust suppression of lipid Reactive Oxygen Species (ROS). Ferroptosis-IN-21 significantly ameliorates renal I/R injury in mice, reducing histological damage, functional impairment, and inflammatory cytokine expression, while decreasing lipid peroxidation biomarkers such as 4-hydroxynonenal. Ferroptosis-IN-12 can be used for research in the field of ferroptosis-targeted drug development .
Cat. No.: HY-W099504S1
CAS No.: 1219804-99-5
Synonyms: n-Heptyl alcohol-d7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
