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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
130 Results for "
(M-R,V-R)S. aureus
" in MedChemExpress (MCE) Product Catalog:
Products (130)
130 Results for "(M-R,V-R)S. aureus" in MCE Product Catalog:
4
1
Target:
1
Sortase A, S. aureus (SrtA), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus plays an important part in ligation of various molecules on the cell surfaces .
1
1 Cited Publications
Target:
GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway . MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus
1
1 Cited Publications
Art. -Nr.: HY-E70234A
Target:
Forschungsgebiete:
Sortase A, S. aureus (non-Ca 2+-dependent), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus (non-Ca 2+-dependent) plays an important part in ligation of various molecules on the cell surfaces .
1
1 Cited Publications
Art. -Nr.: HY-16115
CAS. Nr.: 157124-84-0
Target:
Forschungsgebiete:
BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation) .
1
1
1 Cited Publications
Art. -Nr.: HY-P71828
Reinheit: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCAT; Malonyl-CoA-Acyl Carrier Protein Transacylase, Mitochondrial; Malonyl-CoA-Acyl Carrier Protein Transacylase; Malonyl CoA:ACP Acyltransferase (Mitochondrial); MCT; Mitochondrial Malonyl CoA:ACP Acyltransferase; MT; [Acyl-Carrier-Protein] S-Malonyltra
Species:
Staphylococcus aureus
Source:
P. pastoris
PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 μM, respectively .
Art. -Nr.: HY-P10486
CAS. Nr.: 200010-31-7
Art. -Nr.: HY-18702
CAS. Nr.: 1200443-21-5
Targocil functions as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) with MIC90s of 2 μg/ mL for both MRSA and MSSA.
Art. -Nr.: HY-153695
CAS. Nr.: 1609670-89-4
TXA707 is an FtsZ-targeting antibacterial agent. TXA707 disrupts bacterial septum formation, induces cell enlargement, causes penicillin-binding protein mislocalization, and triggers cell lysis in Staphylococcus aureus cells. TXA707 can be used for the research of Staphylococcus aureus infections .
Synonyms: (S)-(-)-Nadifloxacin; WCK 771
Target:
Forschungsgebiete:
Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes .
Art. -Nr.: HY-P99770
CAS. Nr.: 2241724-48-9
Synonyms: 514-G3
Art. -Nr.: HY-W248907
CAS. Nr.: 495-08-9
Target:
Category:
Infection Triterpenes Plant Terpenoids Rosaceae Extract Disease Research Fields Sanguisorba officinalis Linn. Extract
Target:
KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells .
Art. -Nr.: HY-135184
CAS. Nr.: 922717-97-3
Synonyms: CBR-2092; TNP-2092
Target:
Forschungsgebiete:
Rifaquizinone (CBR-2092; TNP-2092) is a rifamycin-quinolone hybrid antibiotic. Rifaquizinone has an IC50 of 0.034 μM against wild-type Staphylococcus aureus DNA-dependent RNA polymerase. Rifaquizinone potently inhibits Staphylococcus aureus infection, with an MIC range of 0.008-0.5 μg/mL against 300 clinical isolates of staphylococci and streptococci. Rifaquizinone can be used in research related to persistent Staphylococcus aureus infections .
Art. -Nr.: HY-124199
CAS. Nr.: 25908-26-3
Category:
Target:
Art. -Nr.: HY-116486
CAS. Nr.: 170713-71-0
Synonyms: Phevalin
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
