171 Results for "

6R

" in MedChemExpress (MCE) Product Catalog:
Products (171)

171 Results for "6R" in MCE Product Catalog:

45
45 Publications Verification
Cat. No.: HY-P9917
CAS No.: 375823-41-9
Synonyms: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .
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3
3 Cited Publications
Cat. No.: HY-A0124A
CAS No.: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .
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2
2 Cited Publications
Cat. No.: HY-P7223
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuIL-6R; IL-6RA; IL-6R 1; CD126; Membrane glycoprotein 80
Species:  
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-14645A
CAS No.: 287194-41-6
Purity:  99.33%
Synonyms: (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ
Target:  

Keap1-Nrf2

Research Areas:  

Inflammation/Immunology

(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.
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1
1 Cited Publications
Cat. No.: HY-P990211

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer .
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1
1 Cited Publications
Cat. No.: HY-P10284
CAS No.: 853248-13-2
S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .
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1
1 Cited Publications
Cat. No.: HY-107330
CAS No.: 92636-39-0
Purity:  98.19%
Target:  

Antibiotic

Research Areas:  

Others

(6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity .
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1
1 Cited Publications
Cat. No.: HY-P76370
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130
Species:  
Source:  
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Cat. No.: HY-P99112
CAS No.: 1535963-91-7
Synonyms: RG-6168; SA-237

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .
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Cat. No.: HY-B1175
CAS No.: 4697-14-7
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

(2S,5R,6R)-Ticarcillin disodium is a semisynthetic antibiotic with bactericidal activities. (2S,5R,6R)-Ticarcillin disodium is the (2S,5R,6R)-enantiomer of Ticarcillin (HY-139805) .
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Cat. No.: HY-P99385
CAS No.: 1628814-88-9
Synonyms: ALX-0061

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-human serum albumin (ALB) monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .
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Cat. No.: HY-101955A
CAS No.: 1430202-69-9
Purity:  99.61%
Synonyms: (2R,6R)-HNK hydrochloride
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

(2R,6R)-Hydroxynorketamine ((2R,6R)-HNK) hydrochloride is an active ketamine metabolite with no NMDAR binding activity. (2R,6R)-Hydroxynorketamine hydrochloride rescues impaired dorsal hippocampal long-term potentiation and restores robust long-term potentiation in the hippocampal SC-CA1 pathway. (2R,6R)-Hydroxynorketamine hydrochloride can be used for research on depression .
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Cat. No.: HY-101335
CAS No.: 147782-19-2
Purity:  ≥99.0%
Target:  

mGluR

Research Areas:  

Neurological Disease

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .
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Cat. No.: HY-P0317
Target:  

Interleukin Related

Research Areas:  

Others

IL-6R (352-363) is a peptide fragment of IL-6R with the amino acid sequence TSLPVQDSSSVP .
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Cat. No.: HY-P990012
CAS No.: 2744320-12-3
Synonyms: EBI-031

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Vamikibart (EBI-031) is a humanized IgG2κ monoclonal antibody targeting IL-6, with high binding affinity for IL-6 and the IL-6/IL-6R complex. Vamikibart reduces central retinal thickness, resolves intraretinal and subretinal foveal fluid, and decreases the levels of intraocular inflammatory markers. Vamikibart can be used in studies of uveitic macular edema (UME) secondary to non-infectious uveitis .
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Cat. No.: HY-177063
CAS No.: 296790-70-0
Target:  

Interleukin Related

Research Areas:  

Infection Inflammation/Immunology

IL-6-IN-2 is an interleukin-6 (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block IL-6/IL-6R heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .
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Cat. No.: HY-D1480
CAS No.: 2766-77-0
Target:  

Fluorescent Dye

Research Areas:  

Others

Crystal Ponceau 6R is a red azo dye. Crystal Ponceau 6R used in histology, for staining fibrin with the martius, scarlet and blue (MSB) Trichrome stain .
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Cat. No.: HY-A0124
CAS No.: 62989-33-7
Synonyms: (6R)-BH4; (6R)-Tetrahydro-L-biopterin
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .
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Cat. No.: HY-A0124AR
CAS No.: 69056-38-8
Synonyms: (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .
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Cat. No.: HY-W578482
CAS No.: 1109284-40-3
Target:  

Drug Intermediate

Research Areas:  

Others

(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol is a drug intermediate for synthesis of various active compounds.
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