ADAM10

Isoforms Recommended:	ADAM10

By Targets:	Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (2) Carbonic Anhydrase (1) Cholecystokinin Receptor (1) Drug Intermediate (1) EGFR (1) ERK (1) Fluorescent Dye (2) Isotope-Labeled Compounds (1) LAG-3 (1) MMP (19) NF-κB (1) P2X Receptor (1) Reference Standards (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) Syk (1) TNF Receptor (1) TREM receptor (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (3) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-115670

GW280264X 5+ Cited Publications	MMP	Inflammation/Immunology Cancer
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and *ADAM10* with IC₅₀s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .

HY-16657

TAPI-1 10+ Cited Publications	MMP NF-κB Apoptosis TNF Receptor	Inflammation/Immunology Cancer
TAPI-1 is a broad-spectrum MMP inhibitor and NF-κB p65 inhibitor that targets **ADAM17/TACE, ADAM10 and other proteins. TAPI-1 reduces the proteolytic cleavage of membrane-bound TNF-α, decreases TNF-α levels, inhibits NF-κB pathway activation, and downregulates profibrotic markers. TAPI-1 reduces the proportion of proinflammatory immune cells, alleviates cardiac and airway fibrosis, and improves cardiac function after myocardial infarction. Meanwhile, TAPI-1 inhibits the viability, migration and invasion of esophageal squamous cell carcinoma cells, enhances the chemosensitivity of Cisplatin (HY-17394), induces apoptosis**, and shows low toxicity to normal esophageal epithelial cells. TAPI-1 can be widely used in studies related to myocardial infarction-induced heart failure, severe traumatic tracheal stenosis, esophageal squamous cell carcinoma and other conditions .

HY-19956

GI254023X Maximum Cited Publications 19 Publications Verification GI4023; SRI028594	MMP	Cancer
GI254023X is a potent MMP9 and *ADAM10* inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

HY-110397

KP-457 3 Publications Verification	MMP	Cardiovascular Disease
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

HY-10293

Aderbasib 1 Publications Verification INCB007839; INCB7839	MMP	Cancer
Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of *ADAM10* and *ADAM17*. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 ⁺ breast cancer, gliomas, et al .

HY-12636

INCB3619	MMP Apoptosis	Cancer
INCB3619 is a selective and orally active *ADAM* inhibitor with IC₅₀ of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity .

HY-120852

JG26 1 Publications Verification	Angiotensin-converting Enzyme (ACE) MMP EGFR ERK SARS-CoV	Infection Cardiovascular Disease Cancer
JG26 is an *ADAM* inhibitor with IC₅₀ values of 12 nM, 1.9 nM, and 150 nM for ADAM8, ADAM17, and ADAM10, respectively. JG26 inhibits MMP-12 with an IC₅₀ value of 9.4 nM. JG26 inhibits AngII (HY-13948)-induced EGFR transactivation and ERK activation. JG26 increases the expression of ACE2, inhibits the cleavage of CD23, reduces the infection of SARS-CoV-2. JG26 inhibits colorectal cancer metastasis. JG26 can be used for research on Hodgkin lymphoma and vascular diseases .

HY-108675

PPNDS tetrasodium	MMP P2X Receptor	Infection Cancer
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC₅₀: 80 nM, K_i: 8 nM), and also inhibits *ADAM10* (IC₅₀: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers .

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-RS00266

Adam10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
Adam10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Adam10 Mouse Pre-designed siRNA Set A Adam10 Mouse Pre-designed siRNA Set A

HY-RS00265

ADAM10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAM10 Human Pre-designed siRNA Set A ADAM10 Human Pre-designed siRNA Set A

HY-P99027

Ieramilimab LAG525; IMP701; Hu5A8	LAG-3	Cancer
Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .

HY-RS00267

ADAM10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) MMP	Others
ADAM10 Rat Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADAM10 Rat Pre-designed siRNA Set A ADAM10 Rat Pre-designed siRNA Set A

HY-P11540

CCKBR agonist-1	Cholecystokinin Receptor MMP Amyloid-β	Neurological Disease
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC₅₀ of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC₅₀ of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease .

HY-P991857

*Anti-Human/Mouse/Bovine ADAM10* Antibody (8C7)**	MMP	Inflammation/Immunology
Anti-Human/Mouse/Bovine ADAM10 Antibody (8C7) is an antibody against human, mouse, bovine *ADAM10*. Recommend Isotype Controls:?Rat IgG2a kappa, Isotype Control (HY-P990679).

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

HY-W703549

Aderbasib-d3 INCB007839-d₃; INCB7839-d₃	Isotope-Labeled Compounds MMP	Cancer
Aderbasib-d₃ (INCB007839-d₃) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of *ADAM10* and *ADAM17*. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 ⁺?breast cancer, gliomas, et al .

HY-164504

NRMA-10	MMP	Neurological Disease
NRMA-10, an amide prodrug, is a brain-penetrant nuclear receptor modulator. NRMA-10 increases brain expression of Adam10. NRMA-10 preferres distribution to the CNS compared to the periphery. NRMA-10 can be used for the study of central nervous system (CNS) disorders .

HY-182702

As48	TREM receptor Syk	Neurological Disease
As48 is a selective TREM2 agonist with a K_D value of 12.48 μM in TRIC binding assay. As48 binds near the TREM2 cleavage region, forms hydrogen bonds with Gly68, reduces conformational flexibility in regions 58-102, restricts protease accessibility to the cleavage site. As48 activates SYK phosphorylation, enhances microglial phagocytosis, and induces downstream calcium signaling in TREM2-expressing cells. As48 inhibits TREM2 ectodomain shedding without affecting ADAM10/17 protease activities. As48 can be used for the research of Alzheimer's disease .

HY-10293R

Aderbasib (Standard) INCB007839 (Standard); INCB7839 (Standard)	Reference Standards MMP	Cancer
Aderbasib (Standard) is the analytical standard of Aderbasib (HY-10293). This product is intended for research and analytical applications. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, gliomas, et al .

HY-164508

NRMA-6	Drug Intermediate	Neurological Disease
NRMA-6, an amide prodrug, is a nuclear receptor modulator .

HY-P991887

CA9hu-1	Carbonic Anhydrase	Cancer
CA9hu-1 is an internalization‑inducing antibody. CA9hu-1 triggers internalization of CA IX in cells. CA9hu-1 can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-110397G

KP-457	Fluorescent Dye
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

KP-457

Fluorescent Dye

KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

Cat. No.	Product Name	Type

HY-110397G

KP-457	Biochemical Assay Reagents
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

KP-457

Biochemical Assay Reagents

KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

Cat. No.	Product Name	Target	Research Area

HY-P3722

Mca-PLAQAV-Dpa-RSSSR-NH2 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P3722A

Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 1 Publications Verification	Fluorescent Dye MMP	Others
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescent substrate peptide that can be used to detect *ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17).* Mca-PLAQAV-Dpa-RSSSR-NH2 TFA is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm ; Em = 405 nm) .

HY-P11540

CCKBR agonist-1	Cholecystokinin Receptor MMP Amyloid-β	Neurological Disease
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC₅₀ of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC₅₀ of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99027

Ieramilimab LAG525; IMP701; Hu5A8	LAG-3	Cancer
Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules. Ieramilimab restores T-cell and NK-cell-mediated antileukemic immunity by reducing exhaustion and augmenting cytokine output and cytotoxicity. Ieramilimab increases the infiltration of cytotoxic T lymphocytes and reduces baseline densities of regulatory T cells (Tregs) and ADAM10-expressing tumor cells. Ieramilimab can be used for the study of various malignancies including melanoma, RCC, and advanced solid tumors .

HY-P991857

*Anti-Human/Mouse/Bovine ADAM10* Antibody (8C7)**	MMP	Inflammation/Immunology
Anti-Human/Mouse/Bovine ADAM10 Antibody (8C7) is an antibody against human, mouse, bovine *ADAM10*. Recommend Isotype Controls:?Rat IgG2a kappa, Isotype Control (HY-P990679).

HY-P991887

CA9hu-1	Carbonic Anhydrase	Cancer
CA9hu-1 is an internalization‑inducing antibody. CA9hu-1 triggers internalization of CA IX in cells. CA9hu-1 can be used for the research of cancer .

Recombinant Proteins Recommended:

ADAM10

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702498

	ADAM10 Protein, Human (HEK293, His) a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase domain 10; AD10; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; CD156c antigen; CD156c; CDw156; disintegrin and metalloproteinase domain-containing protein 10; EC 3.4.24; HsT18717; kuz; Kuzbanian protein homolog; Kuzbanian; MADM; MADMEC 3.4.24.81; Mammalian disintegrin-metalloprotease	Human	HEK293
	The ADAM10 protein cleaves TNF-α precursor, releasing a soluble form, and mediates the proteolytic release of JAM3 and various cell surface proteins. ADAM10 Protein, Human (HEK293, His) is the recombinant human-derived ADAM10 protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W703549

Aderbasib-d3
Aderbasib-d₃ (INCB007839-d₃) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of *ADAM10* and *ADAM17*. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 ⁺?breast cancer, gliomas, et al .

Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (3) ICC/IF (1) IP (2) WB (2) FC (2) ELISA (3)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86137

	ADAM10 Antibody (YA5829) ADAM10; KUZ; MADM; Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ADAM10 Antibody (YA5829) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAM10.

HY-P83547

	ADAM10 Antibody (YA3292) CDw156; CD156c; ADAM10; KUZ; MADM	WB, IP	Human, Mouse, Rat
	ADAM10 Antibody (YA3292) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ADAM10.

HY-P83804

	ADAM10 Antibody (YA3501) RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717	IHC-P, FC, ELISA	Human
	ADAM10 Antibody (YA3501) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM10.

HY-P83804A

	ADAM10 Antibody (YA3501)(PBS only) RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717	IHC-P, FC, ELISA	Human
	ADAM10 Antibody (YA3501) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADAM10.

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Cat. No.	Product Name		Classification

HY-RS00266

Adam10 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Adam10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00265

ADAM10 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00267

ADAM10 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
ADAM10 Rat Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110397G

KP-457	MMP	Cardiovascular Disease
KP-457 (GMP) is KP-457 (HY-110397) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture.KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC₅₀s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively .

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Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

GMP Molecules