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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
ADO
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "ADO" in MCE Product Catalog:
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7 Publications Verification
Cat. No.: HY-P9921
CAS No.: 1018448-65-1
Synonyms: ADO-Trastuzumab emtansine; PRO132365; T-DM 1
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (HY-19792). Trastuzumab emtansine can be used for the research of advanced breast cancer .
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7 Publications Verification
Cat. No.: HY-P9921A
CAS No.: 1018448-65-1
Synonyms: ADO-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)
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8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice .
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Cardiovascular Disease Neurological Disease Inflammation/Immunology
AK-IN-1 (compound 4072-2732) is an adenosine kinase (AK) inhibitor that is competitive for adenosine (Ado) but not for ATP. AK-IN-1 inhibits 86%, 87% and 89% of AK activity at concentrations of 2, 4 and 10 µM, respectively. AK-IN-1 has good potential for research in many disease areas, including ischaemia, inflammation and seizures .
Cat. No.: HY-19842
CAS No.: 618380-90-8
Synonyms: CVT 3619
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GS-9667 (CVT 3619), a novel N 6-5'-substituted adenosine analog, is a selective, partial agonist of the A1 adenosine receptor (A1AdoR). GS-9667 binds to adipocyte membranes with high (KH=14 nM) and low (KL=5.4 μM) affinities. GS-9667 reduces cyclic AMP content and release of nonesterified fatty acids from epididymal adipocytes with IC50 values of 6 nM and 44 nM, respectively. GS-9667 inhibits lipolysis and has the potential for Type 2 diabetes (T2DM) and dyslipidemia via lowering of free fatty acids (FFA) .
Cat. No.: HY-15903
CAS No.: 82692-96-4
Cat. No.: HY-W101723
CAS No.: 18934-81-1
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Boc-12-Ado-OH can be used as a PROTAC linker in the synthesis of PROTACs. Boc-12-Ado-OH is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Cat. No.: HY-RS00390
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ADO Human Pre-designed siRNA Set A contains three designed siRNAs for ADO gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18889
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Ado Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ado gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25380
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Ado Rat Pre-designed siRNA Set A contains three designed siRNAs for Ado gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-103400R
CAS No.: 34408-14-5
Synonyms: 8-Cl-ADO (Standard)
Research Areas:
8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice .
Synonyms: 8-Aminoadenosine-5'-O-triphosphate tetrasodium
Cat. No.: HY-134313
CAS No.: 35874-49-8
Synonyms: 8-Aminoadenosine-5'-O-triphosphate
Cat. No.: HY-123196
CAS No.: 342419-09-4
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CVT-2759 is a potent inhibitor of A1-ADOR, with the IC50 values of 0.18 μM and 9.5 μM to reduce the binding of [3H]CPX in the absence and presence of 1 mM GTP. CVT-2759 plays an important role in slowing AV nodal conduction and thereby ventricular rate without causing AV block, bradycardia, atrial arrhythmias, or vasodilation .
Cat. No.: HY-123038
CAS No.: 531506-64-6
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CVT-5440 is a xanthine based, selective, high affinity A2B adenosine receptors (AdoR) antagonist with a Ki of 50 nM (selectivity A1> 200; A2A>200; A3>167). CVT-5440 has the potential for asthma research .
Cat. No.: HY-180424
CAS No.: 352692-70-7
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Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
SYAF080 is a human A₂B adenosine receptor (hA₂B AdoR) antagonist with a Ki of 23.6 nM and a KB of 25.2 nM. SYAF080no relevant inhibition of human CYP450 cytochromes. SYAF080 can be used for the research of inflammation, metabolic and cardiovascular disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
