![[Pyr1]-Apelin-13](https://file.medchemexpress.com/product_pic/hy-p1033.gif "Click to View [Pyr1]-Apelin-13 Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
APJ
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "APJ" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-P1944
CAS No.: 217082-58-1
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10
10 Publications Verification
Cat. No.: HY-P1944A
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10
10 Publications Verification
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ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.
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6 Cited Publications
Cat. No.: HY-P2106
CAS No.: 1886973-05-2
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6 Cited Publications
Cat. No.: HY-P2106A
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5
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4 Cited Publications
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ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of β-arrestin in mouse CXCR6 receptors, with an IC50 of 18 μM. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC50 >79 μM. ML339 has the potential to promote the development of prostate cancer research .
2
2 Cited Publications
Cat. No.: HY-P2537
CAS No.: 229961-08-4
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1
1 Cited Publications
Cat. No.: HY-P7061A
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BMS-986224 is a potent, selective and orally active APJ receptor agonist (Kd = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr 1) apelin-13. BMS-986224 has the potential for the research of heart failure .
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CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents . Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension .
Cat. No.: HY-170419
CAS No.: 3037373-19-3
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APJ receptor agonist 10 is an agonist of the APJ Receptor. APJ receptor agonist 10 can be used for research on pulmonary arterial hypertension .
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ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM) .
Cat. No.: HY-P1066
CAS No.: 217082-57-0
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Cat. No.: HY-P2271
CAS No.: 1313027-43-8
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Cat. No.: HY-P1064
CAS No.: 252642-12-9
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Cat. No.: HY-P1065
CAS No.: 230299-95-3
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Cat. No.: HY-P3162A
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Cat. No.: HY-147751
CAS No.: 1965244-85-2
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APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
