12 Results for "

Aconitic acid

" in MedChemExpress (MCE) Product Catalog:
Products (12)

12 Results for "Aconitic acid" in MCE Product Catalog:

Aconitic acid
Aconitic acid
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Cat. No.: HY-W016814A
CAS No.: 499-12-7
Synonyms: NSC 7616
Target:  

Bacterial

Research Areas:  

Infection

Aconitic acid (NSC 7616) is an Antibacterial agent. Aconitic acid exerts dose-dependent inhibitory effects on Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus in vitro. Aconitic acid can be used in studies related to bacterial infections .
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Higenamine
Higenamine
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12 Publications Verification
Cat. No.: HY-N2037
CAS No.: 5843-65-2
Synonyms: Norcoclaurine; Demethyl-Coclaurine
Category:  

Alkaloids Ranunculaceae Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Disease Research Fields Isoquinoline Alkaloids Endocrinology

Target:  

MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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Higenamine hydrochloride
Higenamine hydrochloride
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12 Publications Verification
Cat. No.: HY-N2037A
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride
Category:  

Plants Lindera aggregata (Sims) Kosterm. Alkaloids Phenols Polyphenols Lauraceae Disease Research Fields Isoquinoline Alkaloids Endocrinology Cancer

Target:  

MAP3K MDM-2/p53 ROS Kinase Apoptosis

Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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(Z)-Aconitic acid
(Z)-Aconitic acid
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2 Cited Publications
Cat. No.: HY-W016814
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Amino Acid Decarboxylase

(Z)-Aconitic acid is an orally active glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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trans-Aconitic acid
trans-Aconitic acid
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Cat. No.: HY-W016813
CAS No.: 4023-65-8
Category:  

Human Gut Microbiota Metabolites Immune System Disorder Ketones, Aldehydes, Acids Other Diseases Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer

Target:  

Parasite

trans-Aconitic acid is an orally active aconitase inhibitor that non-competitively inhibits the conversion of citric acid to cis-aconitic acid and competitively inhibits the conversion of cis-aconitic acid to isocitric acid. trans-Aconitic acid inhibits the growth of Leishmania donovani promastigotes, the transformation of Leishmania donovani amastigotes to promastigotes, and the in vitro proliferation of Leishmania donovani amastigotes within macrophages in vitro. trans-Aconitic acid can be used in research related to visceral leishmaniasis (kala-azar) .
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(Z)-Aconitic acid (Standard)
(Z)-Aconitic acid (Standard)
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Cat. No.: HY-W016814R
CAS No.: 585-84-2
Synonyms: cis-Aconitic acid (Standard)
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite

(Z)-Aconitic acid (Standard) is the analytical standard of (Z)-Aconitic acid. This product is intended for research and analytical applications. (Z)-Aconitic acid is a glutamate decarboxylase inhibitor. (Z)-Aconitic acid reduces IκB-α phosphorylation. (Z)-Aconitic acid inhibits Antigen-induced arthritis and Monosodium urate (HY-B2130A)-induced gout .
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trans-Aconitic acid (Standard)
trans-Aconitic acid (Standard)
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Cat. No.: HY-W016813R
CAS No.: 4023-65-8
Category:  

Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Cancer

Target:  

Reference Standards Endogenous Metabolite

trans-Aconitic acid (Standard) is the analytical standard of trans-Aconitic acid. This product is intended for research and analytical applications. trans-Aconitic acid is present in normal human urine, and it has been suggested that is present in larger amounts with Reye's syndrome and organic aciduria. trans-Aconitic acid is a substrate of enzyme trans-aconitate 2-methyltransferase.
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Higenamine (Standard)
Higenamine (Standard)
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Cat. No.: HY-N2037R
CAS No.: 5843-65-2
Synonyms: Norcoclaurine (Standard); Demethyl-Coclaurine (Standard)
Category:  

Alkaloids Ranunculaceae Phenols Polyphenols  Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids

Target:  

Reference Standards MAP3K MDM-2/p53 Adrenergic Receptor ROS Kinase Apoptosis

Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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Napelline
Napelline
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Cat. No.: HY-N9537
CAS No.: 5008-52-6
Category:  

Alkaloids other families Other Alkaloids Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Napelline is an alkaloid extracted from Baikal aconite (Aconitum baikalensis). Napelline can be used for the research of inflammation, antiexudative and analgesic .
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Higenamine hydrochloride (Standard)
Higenamine hydrochloride (Standard)
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Cat. No.: HY-N2037AR
CAS No.: 11041-94-4
Synonyms: Norcoclaurine hydrochloride (Standard)
Category:  

Alkaloids Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.

Target:  

MAP3K Reference Standards MDM-2/p53 ROS Kinase Apoptosis

Higenamine (hydrochloride) (Standard) is the analytical standard of Higenamine (hydrochloride). This product is intended for research and analytical applications. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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Higenamine-d4-1 hydrochloride
Higenamine-d4-1 hydrochloride
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Cat. No.: HY-N2037AS1
Synonyms: Norcoclaurine-d4-1 hydrochloride; Demethyl-Coclaurine-d4-1 hydrochloride
Higenamine-d4-1 (Norcoclaurine-d4-1) hydrochloride is deuterium labeled Higenamine (hydrochloride). Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .
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cis-Aconitic anhydride
cis-Aconitic anhydride
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Cat. No.: HY-W142402
CAS No.: 6318-55-4
cis-Aconitic anhydride, in the presence of acetic anhydride, can be used to detect and determine aliphatic tert-amines and alkaloids. Cis-aconitine anhydride reacts with aliphatic tertiary amines in alcoholic solution to form a yellow color .
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