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Adenylyl Cyclase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (33) Guanylate Cyclase (1) 5-HT Receptor (4) Adenosine Receptor (1) Adrenergic Receptor (4) Antibiotic (4) Apoptosis (5) Arrestin (1) Autophagy (5) Bacterial (10) Calcium Channel (2) DNA/RNA Synthesis (4) Dopamine Receptor (3) Endogenous Metabolite (1) Environmental Pollutants (1) ERK (1) Fungal (5) GABA Receptor (1) GCGR (1) IKK (5) Isotope-Labeled Compounds (3) Keap1-Nrf2 (5) Mitophagy (5) Nucleoside Antimetabolite/Analog (1) P2X Receptor (2) P2Y Receptor (2) p38 MAPK (2) Parasite (2) Phosphodiesterase (PDE) (1) Potassium Channel (2) Prostaglandin Receptor (2) Ras (1) Reference Standards (8) Sirtuin (5)
By Research Areas:	Cancer (12) Cardiovascular Disease (13) Infection (11) Inflammation/Immunology (9) Metabolic Disease (8) Neurological Disease (14)
Oligonucleotides:	Nucleotide Analogs (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: Adenylate Cyclase PACAP Receptor Guanylate Cyclase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16561

Resveratrol 155+ Cited Publications trans-Resveratrol; SRT501	DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-112461A

NF449 octasodium 4 Publications Verification	P2X Receptor	Cardiovascular Disease
NF449 octasodium is a highly potent P2X₁ receptor antagonist, with IC₅₀s of 0.28, 0.69, and 120 nM for rP2X₁, rP2X₁₊₅, P2X₂₊₃, respectively. NF449 octasodium is a G_sα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to G_sα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G_s .

HY-17592

Bithionol 3 Publications Verification	Environmental Pollutants Bacterial Parasite	Infection Cancer
Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble **adenylyl cyclase** through binding to the allosteric activator site (IC₅₀: 4 μM) .

HY-135878

2',5'-Dideoxyadenosine 5 Publications Verification	Adenylate Cyclase Adrenergic Receptor	Metabolic Disease
2',5'-Dideoxyadenosine is a potent and non-competitive **adenylyl cyclase** inhibitor via binding the P-site with an IC₅₀ of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart .

HY-103194

KH7 5+ Cited Publications	Adenylate Cyclase	Others
KH7 is a *soluble adenylyl* cyclase (sAC)*-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sAC_t protein and heterologously expressed sACt in cellular assays . KH7 is also a cAMP* inhibitor .

HY-103192

MDL12330A 5 Publications Verification RMI12330A	Adenylate Cyclase Potassium Channel	Neurological Disease Cancer
MDL12330A (RMI12330A) is an **adenylyl cyclases** inhibitor. MDL12330A can inhibit K_V channels, increases insulin secretion and Ca ²⁺ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .

HY-16561R

Resveratrol (Standard) 155+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-101279

ST034307 4 Publications Verification	Adenylate Cyclase	Neurological Disease
ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC₅₀ of 2.3 μM.

HY-100524

LRE1 2 Publications Verification	Adenylate Cyclase	Cancer
LRE1 is a specific and allosteric inhibitor of soluble **adenylyl cyclase**.

HY-132298

TDI-10229	Adenylate Cyclase	Others
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC₅₀ of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound .

HY-103195

NKY80 2 Publications Verification	Adenylate Cyclase	Metabolic Disease
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

HY-137683A

Guanosine 5'-O-2-thiodiphosphate trisodium GDPβS trisodium	Adenylate Cyclase	Cardiovascular Disease
Guanosine 5'-O-(2-thiodiphosphate) trisodium (GDPβS trisodium) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) trisodium acts as an inhibitor of adenylyl cyclase (AC) with a K_i value of 600 nM. In the absence of glutamic-pyruvic transaminase (GPT) in cerebral cortex membranes of rodent models, Guanosine 5'-O-(2-thiodiphosphate) trisodium partially activates AC with an EC₅₀ of 400 nM. Guanosine 5'-O-(2-thiodiphosphate) trisodium prevents norepinephrine-induced nitric oxide release in ventricular myocytes .

HY-16561S

Resveratrol-d4 trans-Resveratrol-d₄; SRT501-d₄	Isotope-Labeled Compounds DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-147017

GSK2556286 GSK286	Bacterial	Infection Inflammation/Immunology
GSK2556286 (GSK286) is an orally active and cholesterol-dependent *Mycobacterium tuberculosis* inhibitor. GSK2556286 inhibits *Mycobacterium tuberculosis* inside infected macrophages (IC₅₀ = 0.07 μM in THP-1 cells), in the presence of cholesterol. GSK2556286 acts via Rv1625c, a membrane-bound adenylyl cyclase in *Mycobacterium tuberculosis. GSK2556286 is an Rv1625* agonist leading to increased cAMP and reduced cholesterol metabolism. GSK2556286 can be studied in research for antitubercular purposes .

HY-112461

NF449	P2X Receptor	Cardiovascular Disease
NF449 is a highly potent P2X₁ receptor antagonist, with IC₅₀s of 0.28, 0.69, and 120 nM for rP2X₁, rP2X₁₊₅, P2X₂₊₃, respectively. NF449 is a G_sα-selective G Protein antagonist. NF449 suppresses the rate of GTP[γS] binding to G_sα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to G_s .

HY-103430A

SKF-83566 2 Publications Verification	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM) . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC₁ and AC₅ in the isolated rabbit thoracic aorta . SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation .

HY-107547

BPIPP	Guanylate Cyclase Adenylate Cyclase	Metabolic Disease
BPIPP is a *guanylyl cyclase* type C (GC-C) and adenylyl cyclase** inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research .

HY-146356

Adenylyl cyclase type 2 agonist-1	Adenylate Cyclase	Inflammation/Immunology
Adenylyl cyclase type 2 agonist-1 (Compound 73) is a potent agonist of adenylyl cyclase type 2 (AC2) with the EC₅₀ of 90 nM. Adenylyl cyclase type 2 agonist-1 inhibits expression of Interleukin-6, making it a potential lead compound against respiratory diseases .

HY-111446

EPAC 5376753	Ras	Cardiovascular Disease Metabolic Disease Cancer
EPAC 5376753, a 2-Thiobarbituric acid (HY-77962) derivative, is a selective and allosteric Epac inhibitor. EPAC 5376753 inhibits Epac1 with an IC₅₀ of 4 µM in Swiss 3T3 cells. EPAC 5376753 does not inhibit PKA and adenylyl cyclases .

HY-108565

BMY 45778	Adenylate Cyclase Prostaglandin Receptor	Cardiovascular Disease
BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC₅₀ = 35 nM), rabbit (IC₅₀: 136 nM) and rat (IC₅₀ : 1.3 μM) platelet aggregation. BMY 45778 also activates **adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor** .

HY-145830

AC1-IN-1	Adenylate Cyclase	Neurological Disease
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 μM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain .

HY-16561G

Resveratrol trans-Resveratrol; SRT501	DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561S1

Resveratrol-13C6 trans-Resveratrol-¹³C₆; SRT501-¹³C₆	Isotope-Labeled Compounds DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-116540A

L 858051 dihydrochloride 7DMB-Forskolin	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin) dihydrochloride, an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 dihydrochloride directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 dihydrochloride activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 dihydrochloride maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 dihydrochloride increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 dihydrochloride serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-155404

Adenylyl cyclase-IN-1	Adenylate Cyclase	Others
Adenylyl cyclase-IN-1 is an adenylyl cyclase inhibitor with potential use in ocular hypotonia research .

HY-129710

CGP47656	GABA Receptor	Neurological Disease
CGP47656 is a potent GABA_B receptor agonist that inhibits Forskolin (HY-15371)-stimulated adenylyl cyclase activity and augments noradrenaline-stimulated adenylyl cyclase activity. CGP47656 is promising for research of brain function-related diseases .

HY-169263

AC10142A	Adenylate Cyclase	Neurological Disease Inflammation/Immunology
AC10142A is a selective Adenylyl Cyclase Type 1 inhibitor with IC₅₀ of 0.26 μM. AC10142A can be used to study pain models .

HY-115748A

Mant-GTPγS triammonium	Adenylate Cyclase	Cardiovascular Disease
Mant-GTPγS triammonium, a GTP mimetic, is a potent competitive adenylyl cyclase (AC) inhibitor. Mant-GTPγS triammonium is a potent YdeH inhibitor .

HY-17592R

Bithionol (Standard)	Reference Standards Parasite Bacterial	Infection Cancer
Bithionol (Standard) is the analytical standard of Bithionol. This product is intended for research and analytical applications. Bithionol is an antibacterial, anthelmintic, and algaecide agent. Bithionol is also a potent inhibitor of soluble **adenylyl cyclase** through binding to the allosteric activator site (IC₅₀: 4 μM) .

HY-137934

Deacetylforskolin 7-Deacetylforskolin	Endogenous Metabolite	Cardiovascular Disease
Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC₅₀ = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity .

HY-W759997

Reproterol-d3	Isotope-Labeled Compounds Phosphodiesterase (PDE) Adrenergic Receptor	Inflammation/Immunology
Reproterol-d₃ is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research .

HY-134372A

Bis-Br-ANT-ATP tetrasodium	Adenylate Cyclase Bacterial	Infection
Bis-Br-ANT-ATP (tetrasodium) is a fluorescent derivative of adenosine-5’-triphosphate (ATP) (HY-B2176). Bis-Br-ANT-ATP (tetrasodium) selectively inhibits B. pertussis **adenylyl cyclase toxin CyaA (K_i**: 12.6 nM). Bis-Br-ANT-ATP (tetrasodium) can be used in Whooping cough research .

HY-135878R

2',5'-Dideoxyadenosine (Standard)	Adenylate Cyclase Adrenergic Receptor	Metabolic Disease
2',5'-Dideoxyadenosine (Standard) is the analytical standard of 2',5'-Dideoxyadenosine. This product is intended for research and analytical applications. 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart .

HY-128103

Glucagon receptor antagonist-7	GCGR Adenylate Cyclase	Metabolic Disease
Glucagon receptor antagonist-7 (Compound 1) is an antagonist for hGCGR, that inhibits the binding of 125I-labeled glucagon to the human glucagon receptor (hGCGR) with IC₅₀ of 181 nM. Glucagon receptor antagonist-7 activates glucagon-stimulated **adenylyl cyclase with a K_DB** of 81 nM in CHO cell. Glucagon receptor antagonist-7 inhibits glucagon-mediated glycogenolysis in human hepatocytes, and lowers blood glucose levels .

HY-134373A

Bis-Cl-ANT-ATP tetrasodium	Adenylate Cyclase Bacterial	Infection
Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis **Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (K_is** = 16, 1,700, 2,400, and 1,600 nM, respectively). Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough .

HY-137750

MANT-cGMP	Adenylate Cyclase	Cardiovascular Disease Neurological Disease Cancer
MANT-cGMP, a ribose-substituted nucleotide, is an adenylyl cyclase (AC) inhibitor with a K_i of 100 μM and a pK_i of 4. MANT-cGMP can be used for the study of heart failure, cancer, and neurological disorders .

HY-175851

A2AAR antagonist 5	Adenosine Receptor	Neurological Disease
A2AAR antagonist 5 is a selective A_2AAR antagonist. A2AAR antagonist 5 inhibits NECA-stimulated adenylyl cyclase activity in hA_2AAR-expressing CHO cells with an IC₅₀ value of 1863 nM. A2AAR antagonist 5 possesses strong free radical scavenging activity, with an EC₅₀ value of 22.21 μM in the DPPH assay. A2AAR antagonist 5 exerts notable neuroprotective effects in in vitro cerebral ischemia models. A2AAR antagonist 5 can be used for the study of cerebral ischemia .

HY-116295

MRS2690	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .

HY-103430

SKF-83566 hydrobromide	Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 hydrobromide is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT₂ receptor (K_i=11 nM) . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC₂) over AC₁ and AC₅ in the isolated rabbit thoracic aorta . SKF-83566 can be used for the research of parkinson’s disease and nicotine craving alleviation .

HY-116295A

MRS2690 disodium	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .

HY-116540

L 858051 7DMB-Forskolin free base	Adenylate Cyclase	Cardiovascular Disease
L 858051 (7DMB-Forskolin free base), an analog of Forskolin (HY-15371), is an adenylyl cyclase stimulator. L 858051 directly activates adenylyl cyclase to increase intracellular, cellular, and ciliary cAMP levels. L 858051 activates recombinant cyclic nucleotide-gated (E583M CNGA2) channels to induce a non-selective, Mg ²⁺-sensitive current in adult rat ventricular myocytes. L 858051 maximally stimulates L-type Ca ²⁺ current in adult rat ventricular myocytes. L 858051 increases total PDE3 and PDE4 activities in adult rat ventricular myocytes, with effects insensitive to PKA inhibition. L 858051 serves as a tool to elevate intracellular cAMP for studying subsarcolemmal cAMP dynamics and compartmentation in adult rat ventricular myocytes .

HY-101279R

ST034307 (Standard)	Adenylate Cyclase Reference Standards	Neurological Disease
ST034307 (Standard) is the analytical standard of ST034307 (HY-101279). This product is intended for research and analytical applications. ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC50 of 2.3 μM.

HY-185668

2',5'-Dideoxy-3'-ATP	Adenylate Cyclase	Others
2',5'-Dideoxy-3'-ATP is an adenylate cyclase inhibitor. 2',5'-Dideoxy-3'-ATP exerts linear noncompetitive inhibition via binding to the distinct P-site. 2',5'-Dideoxy-3'-ATP binds and stabilizes the dimeric form of Mycobacterium avium adenylyl cyclase Ma1120 to inhibit activity .

HY-182389

NLX-219	5-HT Receptor Adrenergic Receptor ERK Adenylate Cyclase Arrestin	Neurological Disease
NLX-219 is a selective agonist of the 5-HT_1A with a pK_i of 10.21. NLX-219 activates ERK1/2 phosphorylation, inhibits **adenylyl cyclase activity, promotes β-arrestin** recruitment. NLX-219 can be used for the research of neurological disease .

HY-103194R

KH7 (Standard)	Reference Standards Adenylate Cyclase	Others
KH7 (Standard) is the analytical standard of KH7 (HY-103194). This product is intended for research and analytical applications. KH7 is a soluble adenylyl cyclase (sAC)-specific inhibitor, with IC₅₀s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays . KH7 is also a cAMP inhibitor .

HY-103192R

MDL12330A (Standard) RMI12330A (Standard)	Adenylate Cyclase Reference Standards Potassium Channel	Neurological Disease Cancer
MDL12330A (Standard) is the analytical standard of MDL12330A (HY-103192). MDL12330A (RMI12330A) is an **adenylyl cyclases** inhibitor. MDL12330A can inhibit K_V channels, increases insulin secretion and Ca ²⁺ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .

HY-108565R

BMY 45778 (Standard)	Adenylate Cyclase Prostaglandin Receptor Reference Standards	Cardiovascular Disease
BMY 45778 (Standard) is the analytical standard of BMY 45778 (HY-108565). This product is intended for research and analytical applications. BMY 45778 is a non-prostanoid prostacyclin mimetic. BMY 45778 inhibits human (IC₅₀ = 35 nM), rabbit (IC₅₀: 136 nM) and rat (IC₅₀ : 1.3 μM) platelet aggregation. BMY 45778 also activates adenylyl cyclase. BMY 45778 is a partial agonist at the prostacyclin receptor .

HY-103195R

NKY80 (Standard)	Reference Standards Adenylate Cyclase	Metabolic Disease
NKY80 (Standard) is the analytical standard of NKY80 (HY-103195). This product is intended for research and analytical applications. NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

HY-137744

MANT-GppNHp	Adenylate Cyclase Nucleoside Antimetabolite/Analog	Infection
MANT-GppNHp is a competitive adenyl cyclase (AC) inhibitor. MANT-GppNHp is a fluorescently labeled GTP (HY-113225) analogue. MANT-GppNHp interacts with the hydrophobic pocket near the AC catalytic site through its MANT group, thereby directly blocking the binding of the substrate ATP. MANT-GppNHp can be used to study diseases related to the increased activity of AC (such as cholera) .

HY-103430AR

SKF-83566 (Standard)	Reference Standards Dopamine Receptor 5-HT Receptor Adenylate Cyclase	Neurological Disease
SKF-83566 (Standard) is the analytical standard of SKF-83566 (HY-103430A). This product is intended for research and analytical applications. SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM) . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC₅₀ of 5.7 μM . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta . SKF-83566 can be used for research of parkinson’s disease and nicotine craving alleviation .

Cat. No.	Product Name

HY-L165

Dopamine Receptor Compound Library

267 compounds

Dopamine receptor (DAR), widely distributed in the brain, plays a key role in regulating motor function, motivation, driving force and cognition. The role of DA is mediated by D1-type (D1, D5) and D2-type receptors (D2S, D2L, D3, D4), which are distributed in presynaptic, postsynaptic and extrasynaptic, projection neurons and interneurons. Each receptor has a different function. D1 and D5 receptors couple with G stimulation sites and activate Adenylyl cyclase. The activation of Adenylyl cyclase leads to the production of the second messenger cAMP, which leads to the production of protein kinase A (PKA), which leads to further transcription in the nucleus. D2 to D4 receptors are coupled to G inhibitory sites to inhibit adenylyl cyclase and activate potassium Ion channel. These receptors utilize phosphorylation cascades or direct membrane interactions to affect the functions of voltage-gated and neurotransmitter-gated channels, cytoplasmic enzymes, and transcription factors. Dopamine receptor plays an important role in daily life.

MCE designs a unique collection of 267 small molecules related to dopamine receptor. It is a good tool for screening drugs from nervous system disease.

Cat. No.	Product Name	Type

HY-16561G

Resveratrol

trans-Resveratrol; SRT501

Fluorescent Dyes

Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-16561G

Resveratrol

trans-Resveratrol; SRT501

Biochemical Assay Reagents

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16561

Resveratrol 155+ Cited Publications trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Vitis vinifera cv. Zalema Plants Vitaceae Infection Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501) is a CNS-penetrant natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561R

Resveratrol (Standard) 155+ Cited Publications trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	Reference Standards IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-137934

Deacetylforskolin 7-Deacetylforskolin	Terpenoids Labiatae Diterpenoids Plants Pueraria montana (Lour.) Merr. Source Classification	Endogenous Metabolite
Deacetylforskolin is a deacetylated derivative of forskolin (HY-15371) that can be extracted from C. forskohlii. Deacetylforskolin activates rat adipocyte adenylyl cyclase (IC₅₀ = 20 µM), inhibits glucose transport in rat adipocyte plasma membranes and exhibits antihypertensive activity .

Cat. No.	Product Name	Chemical Structure

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-W759997

Reproterol-d3
Reproterol-d₃ is the deuterium labeled Reproterol (HY-135490). Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research .

Cat. No.	Product Name		Classification

HY-185668

2',5'-Dideoxy-3'-ATP		Nucleotide Analogs
2',5'-Dideoxy-3'-ATP is an adenylate cyclase inhibitor. 2',5'-Dideoxy-3'-ATP exerts linear noncompetitive inhibition via binding to the distinct P-site. 2',5'-Dideoxy-3'-ATP binds and stabilizes the dimeric form of Mycobacterium avium adenylyl cyclase Ma1120 to inhibit activity .

Targets Recommended: Adenylate Cyclase PACAP Receptor Guanylate Cyclase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16561G

Resveratrol trans-Resveratrol; SRT501	DNA/RNA Synthesis IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Keap1-Nrf2	Infection Inflammation/Immunology Cancer
Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, **Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1** activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

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Adenylyl Cyclase Inhibitor

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