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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
Cav3.2
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "Cav3.2" in MCE Product Catalog:
87
87
87 Publications Verification
Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
2
2 Cited Publications
Synonyms: L-Ascorbate (Standard); Vitamin C (Standard)
2
2 Cited Publications
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ML218 is a potent, selective and orally active T-type Ca 2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier .
1
1 Cited Publications
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TTA-A2 is a potent, selective and orally active t-type voltage gated calcium channel antagonist with reduced pregnane X receptor (PXR) activation. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy .
1
1 Cited Publications
Synonyms: 6-Prenylnaringenin; (±)-6-Prenylnaringenin
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(2R/S)-6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca 2+ channels (T-channels) blocker. (2R/S)-6-PNG can penetrate the blood-brain barrier (BBB). (2R/S)-6-PNG suppresses neuropathic and visceral pain in mice .
1
1 Cited Publications
Cat. No.: HY-P1441A
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Synonyms: 5,6-EET; (±)5,6-EpETrE
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5,6-Epoxyeicosatrienoic acid (5,6-EET; (±)5,6-EpETrE) is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes. In solution, 5,6-Epoxyeicosatrienoic acid degrades into 5,6-DiHET and 5,6-δ-lactone, which can be converted to 5,6-DiHET and quantified by GC-MS. In neuroendocrine cells, such as the anterior pituitary and pancreatic islets, 5,6-Epoxyeicosatrienoic acid has been implicated in the mobilization of calcium and hormone secretion. 5,6-Epoxyeicosatrienoic acid is an inhibitor of T-type voltage-gated calcium channels (Cav3) that inhibits isoforms Cav3.1, Cav3.2 (IC50=0.54 μM), and Cav3. and decreases nifedipine-resistant phenylephrine-induced vasoconstriction in isolated mouse mesenteric arteries via Cav3.2 blockade when used at a concentration of 3 μM. In addition, it is a substrate of COX-1 and COX-2.
Cat. No.: HY-B0166S
CAS No.: 1354064-87-1
Synonyms: L-Ascorbate-13C6; Vitamin C-13C6
Cat. No.: HY-B0166S8
CAS No.: 1331939-77-5
Synonyms: L-Ascorbate-1; Vitamin C-13C6-1
Cat. No.: HY-B0166S6
CAS No.: 82977-10-4
Synonyms: L-Ascorbate-d2; Vitamin C--d2
Cat. No.: HY-B0166S1
CAS No.: 178101-88-7
Synonyms: L-Ascorbate-13C; Vitamin C-13C
Cat. No.: HY-151452
CAS No.: 2878598-69-5
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Cav 3.2 inhibitor 3 (Compound 4) is a potent Cav3.2 T-type Ca 2+ channel inhibitor with an IC50 of 0.1534 μM, and has little binding affinity to D2 receptors .
Cat. No.: HY-B0166GL
CAS No.: 50-81-7
Synonyms: L-Ascorbate (GMP Like); Vitamin C (GMP Like)
Cat. No.: HY-B0166S3
CAS No.: 1313730-17-4
Synonyms: L-Ascorbate-13C-2; Vitamin C-13C-2
Cat. No.: HY-B0166S2
CAS No.: 178101-89-8
Synonyms: L-Ascorbate-13C-1; Vitamin C-13C-1
Cat. No.: HY-B0166S5
CAS No.: 149153-08-2
Synonyms: L-Ascorbate-13C-4; Vitamin C-13C-4
Cat. No.: HY-154832
CAS No.: 1416984-93-4
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Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitor, with an IC50 of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation .
Cat. No.: HY-B0166AR
CAS No.: 134-03-2
Synonyms: Sodium ascorbate (Standard); Sodium L-ascorbate (Standard); Vitamin C sodium salt (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
