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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
Cytoprotective effect
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "Cytoprotective effect" in MCE Product Catalog:
4
4 Cited Publications
연구분야:
BL-918 is an orally active UNC-51-like kinase 1 (ULK1) activator with an EC50 of 24.14 nM. BL-918 exerts its cytoprotective autophagic effect by targeting ULK complex. BL-918 has the potential for Parkinson’s disease (PD) treatment .
2
Category:
Infection Ketones, Aldehydes, Acids Araceae Extract Acorus gramineus Soland. Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-N0513
CAS No.: 22255-40-9
Cat. No.: HY-164926
CAS No.: 2640677-68-3
Target:
연구분야:
PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM). PARP1-IN-33 has retinal cytoprotective effect, with an EC50 of 0.02 nM (inhibition on MTS activity of H2O2 induced human retinal pigment epithelial cell) .
Category:
Alkaloids Zygophyllaceae Extract Other Alkaloids Peganum harmala Linn. Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-N0377A
CAS No.: 69097-97-8
Synonyms: (±)-4',7-Dihydroxyflavanone
Target:
Cat. No.: HY-151526
CAS No.: 1360243-08-8
Target:
연구분야:
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death .
Cat. No.: HY-177100
CAS No.: 2640677-63-8
Lotixparib (Example 1) is an inhibitor of poly(ADP-ribose)polymerase-1 (PARP-1). Lotixparib has cytoprotective effect against a retinal disease. Lotixparib can be studied in research for PARP-1-associated diseases .
Cat. No.: HY-117356B
CAS No.: 1448858-83-0
Target:
연구분야:
MRS2693 trisodium is a selective P2Y6 agonist with an EC50 value of 0.015 μM. MRS2693 trisodium can reduce the activation of NF-kappaB and activate the ERK1/2 pathway, and has a cytoprotective effect on mouse hindlimb skeletal muscle ischemia-reperfusion injury model .
Cat. No.: HY-106322
CAS No.: 114833-91-9
IO-21 (Compound 3) is a candidate cytoprotective agent. IO-21 exhibits a marked cytoprotective effect. IO-21 shows a potent inhibitory activity against HCl•ethanol-induced lesions. IO-21 shows a MIC of 50 μg/mL against Helicobacter pylori 7795. IO-21 can be used in the research of gastric mucosal ulcers .
Cat. No.: HY-161717
CAS No.: 1377272-66-6
Target:
연구분야:
MRS5663 (Compound 3a) is an A3AR agonist, with an EC50 of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model .
Cat. No.: HY-N10642
CAS No.: 160789-41-3
Target:
Target:
Cat. No.: HY-W013605AR
CAS No.: 1963-36-6
Synonyms: p-Methoxycinnamaldehyde (Standard)
Target:
Cat. No.: HY-N0513R
CAS No.: 22255-40-9
Cat. No.: HY-138135
CAS No.: 1030825-28-5
Synonyms: Fidaxomicin metabolite OP-1118
OP-1118 (Fidaxomicin metabolite OP-1118) is an orally active dual inhibitor of NF-κB and ERK1/2, with low systemic plasma exposure, no accumulation, and primary excretion via feces. By inhibiting the phosphorylation of NF-κB and ERK1/2 and reducing the expression of pro-inflammatory cytokines, OP-1118 exerts significant anti-inflammatory, cytoprotective, anti-apoptotic and antibacterial activities. In Clostridium difficile infection models, OP-1118 effectively blocks toxin-mediated intestinal inflammation, cell rounding, histological damage and apoptosis, and its protective effect can be reversed by PMA (HY-18739) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
