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Dehydrogenation

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By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) Biochemical Assay Reagents (3) CD38 (1) Drug Intermediate (3) Drug Metabolite (2) Endogenous Metabolite (4) Environmental Pollutants (1) Fluorescent Dye (2) FXR (1) METTL3 (1) Neurokinin Receptor (1) Reference Standards (1)
By Research Areas:	Cancer (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (3)

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Fluorescent Dye

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0079

Dihydroethidium 170+ Cited Publications Hydroethidine; PD-MY 003	Fluorescent Dye	Others
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .

HY-N4067

Isochenodeoxycholic acid isoCDCA	FXR Endogenous Metabolite	Metabolic Disease
Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .

HY-P3186A

NAD-dependent Glucose dehydrogenase GDH-NAD	Endogenous Metabolite	Metabolic Disease
NAD-dependent glucose dehydrogenase (GDH-NAD) is an oxidoreductase that uses NAD ⁺ as a coenzyme, specifically catalyzes the dehydrogenation of glucose to gluconolactone, and reduces NAD ⁺ to NADH. NAD-dependent glucose dehydrogenase exhibits favorable substrate selectivity and stability, and is not affected by oxygen .

HY-N4031

Humantenine	Anaplastic lymphoma kinase (ALK) METTL3	Inflammation/Immunology
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-118614

β-Nicotyrine	Drug Metabolite	Neurological Disease
β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .

HY-DY1015

Dihydroethidium (solution)	Fluorescent Dye	Others
Dihydroethidium (solution) , also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation . Solvent and concentration: DMSO: 5 mM

HY-W015003

9-Ethylcarbazole N-Ethylcarbazole	Biochemical Assay Reagents	Others
9-Ethylcarbazole (N-Ethylcarbazole) serves as a hydrogen storage material. The introduction of nitrogen (N) into 9-ethylcarbazole can reduce the endothermic nature of the reaction and decrease the dehydrogenation temperature, thereby facilitating the process of hydrogen storage and release .

HY-W010283

2,3-Dimethylindole	Biochemical Assay Reagents	Others
2,3-Dimethylindol is an organic liquid hydrogen carrier (LOHC). 2,3-Dimethylindol enables reversible hydrogen storage and release via catalytic hydrogenation/dehydrogenation reactions. 2,3-Dimethylindol is promising for research of clean energy storage .

HY-W102516

6-Dehydroprogesterone Δ6-Progesterone	Endogenous Metabolite	Others
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

HY-N7372

Licoisoflavanone	Apoptosis	Infection Inflammation/Immunology
Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-W587751

Arteannuic alcohol Amorpha-4,11-diene-12-ol	Drug Intermediate	Infection
Arteannuic alcohol (Amorpha-4,11-diene-12-ol) is a precursor substance in the biosynthetic pathway of Artemisinin (HY-B0094). Alcohol dehydrogenase catalyzes the dehydrogenation reaction of chlorogenic alcohol to produce artemisinic aldehyde .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

HY-N2561

Seneciphylline N-Oxide	Others	Cancer
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

HY-W034154

Dihydridotetrakis(triphenylphosphine)ruthenium(II) Tetrakis(triphenylphosphine)ruthenium dihydride	Drug Intermediate Endogenous Metabolite
Dihydridotetrakis(triphenylphosphine)ruthenium(II) (Tetrakis(triphenylphosphine)ruthenium dihydride) is a catalyst with good catalytic activity. Dihydridotetrakis(triphenylphosphine)ruthenium(II) can be used in organic synthesis reactions, especially in hydrogenation and dehydrogenation reactions. Dihydridotetrakis(triphenylphosphine)ruthenium(II) has received extensive attention in the study of metal catalysts, and its high efficiency makes it an ideal research object.

HY-W653739

(+)-Abscisic aldehyde Abscisic aldehyde	Drug Intermediate	Others
(+)-Abscisic Aldehyde (ABAld) is an intermediate in the biosynthesis of the plant hormone abscisic acid (ABA). (+)-Abscisic Aldehyde is produced by the dehydrogenation of xanthoxin by xanthoxin dehydrogenases, followed by selective oxidation by abscisic aldehyde oxygenase. (+)-Abscisic Aldehyde has an oxidizing PsAOγ activity and it correlates with ABA accumulation in the old leaves of pea plants with long exposure of salinity, ammonium or nitrogen deficiency. (+)-Abscisic Aldehyde can be used for plant growth and development research .

HY-W042298

Triisobutyl phosphate	Environmental Pollutants	Others
Triisobutyl phosphate is an environmental pollutant that undergoes biodegradation. TiBP can be degraded in activated sludge via hydrolysis, dehydrogenation and hydroxylation, a process mediated by an acclimated microbial community with Pseudomonas as the key strain, and enhanced by TiBP-induced enzymatic activity. TiBP exerts toxic effects on zebrafish embryos .

HY-118614R

β-Nicotyrine (Standard)	Reference Standards Drug Metabolite	Neurological Disease
β-Nicotyrine (Standard) is the analytical standard of β-Nicotyrine. This product is intended for research and analytical applications. β-Nicotyrine is a metabolite of Nicotine.β-Nicotyrine, isolated from the leaves of Nicotiana tabacum plants and from cigarette smoke condensate, is a minor tobacco alkaloid .

HY-E70987

Chloroperoxidase, Caldariomyces fumago	Biochemical Assay Reagents	Metabolic Disease
Chloroperoxidase, Caldariomyces fumago (EC 1.11.1.10) is an extracellular heme glycoenzyme containing ferriprotoporphyrin IX as the prosthetic group. Chloroperoxidase, Caldariomyces fumago (EC 1.11.1.10) is a peroxide-dependent chlorinating enzyme. It also catalyzes peroxidase-, catalase-and cytochrome P450-type reactions of dehydrogenation, H2O2 decomposition and oxygen insertion, respectively.

Cat. No.	Product Name	Type

HY-D0079

Dihydroethidium 170+ Cited Publications Hydroethidine; PD-MY 003	Fluorescent Dye
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .

Dihydroethidium

170+ Cited Publications

Hydroethidine; PD-MY 003

Fluorescent Dye

Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .

HY-DY1015

Dihydroethidium (solution)	Fluorescent Dye
Dihydroethidium (solution) , also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation . Solvent and concentration: DMSO: 5 mM

Dihydroethidium (solution)

Fluorescent Dye

Dihydroethidium (solution) , also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
Solvent and concentration: DMSO: 5 mM

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3820

*[Dehydro-Pro4] Substance P (4-11)*	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
[Dehydro-Pro4] Substance P (4-11) is a peptide fragment of Substance P. Substance P is a peptide mainly secreted by neurons. Substance P takes part in many biological processes, including nociception, inflammation and immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4067

Isochenodeoxycholic acid isoCDCA	Source Classification	FXR Endogenous Metabolite
Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction .

HY-N4031

Humantenine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Anaplastic lymphoma kinase (ALK) METTL3
Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD₅₀ values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .

HY-W102516

6-Dehydroprogesterone Δ6-Progesterone	Endogenous metabolite Steroids Source Classification	Endogenous Metabolite
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .

HY-N7372

Licoisoflavanone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Isoflavanones Other Diseases Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Apoptosis
Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases .

HY-N2561

Seneciphylline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Erinacea anthyllis Link Plants Compositae Disease Research Fields Cancer Source Classification	Others
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

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Dehydrogenation

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Natural
Products