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GATA3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Autophagy (1) DNA/RNA Synthesis (1) Ferroptosis (1) Fungal (1) IFNAR (2) Interleukin Related (3) Itk (1) Mitophagy (1) mRNA (1) NF-κB (2) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (1) Small Interfering RNA (siRNA) (3) STAT (2) TNF Receptor (1)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0407

Picroside I 6'-Cinnamoylcatalpol	STAT	Inflammation/Immunology
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

HY-114495

Caerulomycin A 3 Publications Verification Cerulomycin; Caerulomycin	Fungal Antibiotic	Infection Inflammation/Immunology
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets *Smad3, STAT1* and *GATA-3. Caerulomycin A downregulates GATA-3* expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma ^[3].

HY-138113

Pyrrothiogatain 1 Publications Verification	DNA/RNA Synthesis Interleukin Related TNF Receptor Angiotensin-converting Enzyme (ACE) SARS-CoV	Infection Inflammation/Immunology Cancer
Pyrrothiogatain is a transcription factor *GATA3* inhibitor with an IC₅₀ of 54.7 μM. Pyrrothiogatain inhibits the DNA-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection ^[3] .

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR NF-κB	Inflammation/Immunology
Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a K_d value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates *GATA‑3, increases the production of IL‑2* and IFN‑γ, decreases the production of IL‑4 and IL‑10, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .

HY-N4087

Platycodin D2 3 Publications Verification	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology ^[3].

HY-RS05291

GATA3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GATA3 Human Pre-designed siRNA Set A GATA3 Human Pre-designed siRNA Set A

HY-RS17910

Gata3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gata3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gata3 Mouse Pre-designed siRNA Set A Gata3 Mouse Pre-designed siRNA Set A

HY-174675

*Human GATA3* mRNA**	mRNA	Cancer
Human GATA3 mRNA encodes the human GATA binding protein 3 (GATA3) which belongs to the GATA family. GATA3 is an important regulator of T-cell development. It also plays an important role in endothelial cell biology.

HY-RS24379

Gata3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gata3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gata3 Rat Pre-designed siRNA Set A Gata3 Rat Pre-designed siRNA Set A

HY-185206

BSJ-05-037	PROTACs Itk NF-κB	Cancer
BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the *NF-κB/GATA-3* signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma ^[3].

HY-N0407R

Picroside I (Standard) 6'-Cinnamoylcatalpol (Standard)	Reference Standards STAT	Inflammation/Immunology
Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

Picroside I 6'-Cinnamoylcatalpol	Iridoids Classification of Application Fields Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields Source Classification	STAT
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

Caerulomycin A 3 Publications Verification Cerulomycin; Caerulomycin	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics Source Classification	Fungal Antibiotic
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets *Smad3, STAT1* and *GATA-3. Caerulomycin A downregulates GATA-3* expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma ^[3].

Ginsenoside F3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Interleukin Related IFNAR NF-κB
Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a K_d value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates *GATA‑3, increases the production of IL‑2* and IFN‑γ, decreases the production of IL‑4 and IL‑10, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .

Platycodin D2 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification Cancer	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology ^[3].

Picroside I (Standard) 6'-Cinnamoylcatalpol (Standard)	Structural Classification Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Source Classification	Reference Standards STAT
Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .

Host:	Mouse (3) Rabbit (4)
Reactivity:	Human (7) Rat (3) Mouse (3)
Application:	IHC-P (7) ICC/IF (2) IP (2) WB (7) ChIP (1) FC (3) ELISA (3)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Phosphorylated (1) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85180

	GATA3 Antibody (YA4872) GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3	WB, IHC-P, ICC/IF, ELISA	Human
	GATA3 Antibody (YA4872) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GATA3.

HY-P82848

	*Phospho-GATA3* (Ser308) Antibody (YA2593)** GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-GATA3 (Ser308) Antibody (YA2593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-GATA3 (Ser308).

HY-P82848A

	*Phospho-GATA3* (Ser308) Antibody (YA2593)(PBS only)** GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-GATA3 (Ser308) Antibody (YA2593) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-GATA3 (Ser308).

HY-P82754

	GATA3 Antibody (YA2499) GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3	WB, IHC-P, ICC/IF, ChIP, FC	Human
	GATA3 Antibody (YA2499) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA3.

HY-P84200

	GATA3 Antibody (YA3897) HDR; HDRS	WB, IHC-P, FC, ELISA	Human
	GATA3 Antibody (YA3897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATA3.

HY-P84200A

	GATA3 Antibody (YA3897)(PBS only) HDR; HDRS	WB, IHC-P, FC, ELISA	Human
	GATA3 Antibody (YA3897) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GATA3.

HY-P86888

	GATA2+GATA3 Antibody (YA6581) DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; IMD21 antibody; MONOMAC antibody; NFE1B antibody; Trans acting T cell specific transcription factor GATA 3 antibody; Trans acting T cell specific transcription factor GATA-3 antibody;	WB, IHC-P	Human, Mouse, Rat
	GATA2+GATA3 Antibody (YA6581) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GATA2+GATA3.

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GATA3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gata3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gata3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

*Human GATA3* mRNA**		mRNA
Human GATA3 mRNA encodes the human GATA binding protein 3 (GATA3) which belongs to the GATA family. GATA3 is an important regulator of T-cell development. It also plays an important role in endothelial cell biology.

Gata3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gata3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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