18 Results for "

GATA3

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "GATA3" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-114495
CAS No.: 21802-37-9
Purity:  ≥98.0%
Synonyms: Cerulomycin; Caerulomycin
Caerulomycin A is an orally active immunomodulator and antimicrobial agent. Caerulomycin A targets Smad3, STAT1 and GATA-3. Caerulomycin A downregulates GATA-3 expression, inhibits Th2 cell differentiation and Th2 cytokine production, reduces IgE levels, and alleviates pulmonary inflammatory responses and eosinophil infiltration. Caerulomycin A ameliorates collagen-induced arthritis symptoms, reduces joint inflammation and synovitis, and decreases the levels of proinflammatory cytokines in joints. Caerulomycin A inhibits the growth of some filamentous fungi, yeasts and specific bacteria. Caerulomycin A can be used in research related to arthritis and asthma [3].
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3
3 Cited Publications
Cat. No.: HY-N4087
CAS No.: 66663-90-9
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology [3].
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1
1 Cited Publications
Cat. No.: HY-138113
CAS No.: 477888-48-5
Purity:  98.61%
Pyrrothiogatain is a transcription factor GATA3 inhibitor with an IC50 of 54.7 μM. Pyrrothiogatain inhibits the DNA-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection [3] .
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Cat. No.: HY-N0407
CAS No.: 27409-30-9
Synonyms: 6'-Cinnamoylcatalpol
Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
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Cat. No.: HY-N0600
CAS No.: 62025-50-7
Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a Kd value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates GATA‑3, increases the production of IL‑2 and IFN‑γ, decreases the production of IL‑4 and IL‑10, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .
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Cat. No.: HY-RS05291
Research Areas:  

Others

GATA3 Human Pre-designed siRNA Set A contains three designed siRNAs for GATA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS17910
Research Areas:  

Others

Gata3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-174675
Target:  

mRNA

Research Areas:  

Cancer

Human GATA3 mRNA encodes the human GATA binding protein 3 (GATA3) which belongs to the GATA family. GATA3 is an important regulator of T-cell development. It also plays an important role in endothelial cell biology.
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Cat. No.: HY-RS24379
Research Areas:  

Others

Gata3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gata3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-185206
CAS No.: 2756388-01-7
Target:  

PROTACs Itk NF-κB

Research Areas:  

Cancer

BSJ-05-037 is an ITK PROTAC degrader that effectively targets and degrades ITK in T-cell lymphoma cell lines. BSJ-05-037 blocks the activation of the NF-κB/GATA-3 signaling pathway, inhibits PLCγ1 phosphorylation, and reduces the proliferative capacity of T-cell lymphoma cells. BSJ-05-037 enhances the sensitivity of T-cell lymphoma cells to chemotherapy. In mouse models of T-cell lymphoma, BSJ-05-037 induces ITK degradation, reduces GATA-3 expression, decreases tumor volume, and reverses chemotherapy resistance. BSJ-05-037 is applicable to research related to T-cell lymphoma [3].
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Cat. No.: HY-N0407R
CAS No.: 27409-30-9
Synonyms: 6'-Cinnamoylcatalpol (Standard)
Picroside I (Standard) is the analytical standard of Picroside I. This product is intended for research and analytical applications. Picroside I is the major ingredient of Picrorhiza scrophulariiflora. Picrorhiza scrophulariiflora is a high value medicinal herb due to rich source of hepatoprotective metabolites, Picroside-I and Picroside-II . Picroside I is a promising agent for the management of asthma. Picroside I reduces the inflammation significantly at its higher dose. Picroside I also downregulates pSTAT6 and GATA3 expressions. Picroside I dose-dependently increases the serum levels of IFN-γ .
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Cat. No.: HY-P85180
Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human

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Cat. No.: HY-P82848
Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P82848A
Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P82754
Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, ChIP, FC

Reactivity:  

Human

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Cat. No.: HY-P84200
Synonyms: HDR; HDRS

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84200A
Synonyms: HDR; HDRS

Host:  

Mouse

Application:  

WB, IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P86888
Synonyms: DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; DCML antibody; Endothelial transcription factor GATA 2 antibody; Endothelial transcription factor GATA-2 antibody; GATA binding factor 3 antibody; GATA binding protein 2 antibody; GATA binding protein 3 antibody; GATA-binding protein 2 antibody; GATA-binding protein 3 antibody; HDR antibody; HDRS antibody; IMD21 antibody; MONOMAC antibody; NFE1B antibody; Trans acting T cell specific transcription factor GATA 3 antibody; Trans acting T cell specific transcription factor GATA-3 antibody;

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human, Mouse, Rat

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