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Results for "

Glycyrrhiza glabra

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (1) Bacterial (5) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (3) COX (1) Dengue Virus (1) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (1) ERK (1) Factor Xa (1) FOXO (1) FXR (1) Influenza Virus (1) JNK (1) Keap1-Nrf2 (1) mTOR (1) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (1) PI3K (2) PPAR (2) Reactive Oxygen Species (ROS) (3) SOD (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (6) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N0393

Glabridin Maximum Cited Publications 12 Publications Verification	PPAR Reactive Oxygen Species (ROS) Bacterial	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

HY-N2123

Neoliquiritin 1 Publications Verification	Caspase	Neurological Disease Cancer
Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions .

HY-154795

Magnesium isoglycyrrhizinate hydrate	Caspase NOD-like Receptor (NLR)	Inflammation/Immunology
Magnesium isoglycyrrhizinate hydrate is the active component found in licorice plant (Glycyrrhiza glabra). Magnesium isoglycyrrhizinate hydrate exhibits anti-inflammatory activity through NLRP3 inflammasome pathway, and attenuates the chronic obstructive pulmonary disease in rats .

HY-N4194

Glabrone 1 Publications Verification	PPAR Influenza Virus	Infection Metabolic Disease
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

HY-N6987

Licraside	FXR Factor Xa	Cardiovascular Disease Inflammation/Immunology
Licraside, found in Glycyrrhiza glabra, is a Farnesoid X receptor (FXR) activator. Licraside activates FXR to induce upregulation of SHP and BSEP, regulates bile acid homeostasis, reduces elevated biliary and serum TBA, serum ALT, AST, GGT, ALP, and TBIL levels, and attenuates liver histopathological damage. Licraside inhibits factor Xa with an IC₅₀ of 48.54 mM. Licraside can be used for the research of cholestasis and thromboembolic diseases .

HY-N10144

Shinpterocarpin	PI3K Akt Keap1-Nrf2 Bcl-2 Family SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology
Shinpterocarpin is a flavonoid compound. Shinpterocarpin can be isolated from the air-dried roots of Glycyrrhiza glabra L. and Xuanshen Decoction. Shinpterocarpin binds to the targets PI3K, AKT, Nrf2, Bcl-2, Bax, CAT and SOD. Shinpterocarpin enhances immunity and exerts antioxidant effects by reducing the production of ROS .

HY-N11111

Glycyrrhizin-6'-methylester	Others	Others
Glycyrrhizin-6'-methylester is a natural product that can be isolated from licorice (Glycyrrhiza glabra) .

HY-N10133

Licoflavanone 3′-Prenylnaringenin	Bacterial mTOR Akt PI3K NF-κB Caspase JNK ERK COX NO Synthase Apoptosis	Others
Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms .

HY-N18641

Glycyrrhiza glabra extract	Bacterial	Infection Inflammation/Immunology
Glycyrrhiza glabra extract is rich in bioactive compounds such as glycyrrhizic acid, glycyrrhetinic acid, flavonoids, and glycyrrhizin, and has antioxidant, anti-inflammatory, antibacterial, and skin-protective effects.

HY-N8813

Glucoliquiritin	Others	Others
Glucoliquiritin is a Flavonoids product that can be isolated from the roots of Glycyrrhiza glabra L. .

HY-114693

Licoagrochalcone B	Others	Others
Licoagrochalcone B is a prenylated retrochalcone that can be found in Glycyrrhiza glabra hairy root cultures .

HY-N12289

Kanzonol D	Others	Others
Kanzonol D is a flavonoid compound that can be found in the hairy root cultures of Glycyrrhiza glabra .

HY-W1053643

3,3',5'-Trihydroxy-4-methoxybibenzyl	Drug Derivative	Others
3,3',5'-Trihydroxy-4-methoxybibenzyl is a dihydrostilbene derivative that can be found in the leaves of Glycyrrhiza glabra .

HY-N13021

2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid	Endogenous Metabolite	Others
2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .

HY-N19837

Kanzonol Y	Dengue Virus	Infection Cancer
Kanzonol Y is a chalcone compound that can be found in the roots of Glycyrrhiza glabra. Kanzonol Y exerts anticancer and anti-dengue virus activity .

HY-186188

Licoagrocarpin	Drug Intermediate	Others
Licoagrocarpin is an isoprenylated pterocarpan, a type of naturally occurring flavonoid found in the roots of Glycyrrhiza glabra. Licoagrocarpin serves as a precursor in the biosynthetic pathway of Glabridin (HY-N0393) .

HY-N18007

3-Hydroxyglabrol	Bacterial	Infection
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .

HY-N18824

Licorice oil	Bacterial	Infection Inflammation/Immunology
Licorice oils, derived from the roots and rhizomes of the licorice plant (Glycyrrhiza glabra), are rich in bioactive compounds like glycyrrhizin, flavonoids, and triterpenoid. Licorice oil has anti-inflammatory and antibacterial properties, which can effectively soothe irritated skin, reduce redness, control eczema, and fight acne.

HY-N12385

Hispaglabridin B (R)-Hispaglabridin B	FOXO	Others
Hispaglabridin B is an anti-oxidant agent that can be isolated from Glycyrrhiza glabra. Hispaglabridin B exhibits potent peroxynitrite scavenging activity with an IC₅₀ of 3.2 μM, and shows activity in a low-density lipoprotein (LDL) oxidation system . Hispaglabridin B is also a FoxO1 inhibitor . Hispaglabridin B improves muscle wasting by inhibiting catabolism in vivo and in vitro.

HY-N15622

Neouralenol	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Neouralenol is a free radical scavenger. Neouralenol can be isolated from licorice roots. Neouralenol scavenges hydroxyl radicals and hydroperoxyl radicals .

Glabridin Maximum Cited Publications 12 Publications Verification	Structural Classification Classification of Application Fields Plants Infection Flavonoids Leguminosae Phenols Polyphenols Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	PPAR Reactive Oxygen Species (ROS) Bacterial
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC₅₀ of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .

Neoliquiritin 1 Publications Verification	Structural Classification Monophenols Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Caspase
Neoliquiritin is a flavonoid and flavanone-derived cytotoxic agent with anticancer activity and neuroprotective effects. Neoliquiritin exhibits excellent tumor specificity, exerting a more pronounced killing effect on cancer cells compared with normal oral cells. Neoliquiritin also exerts neuroprotective effects by inhibiting ATP depletion and the elevation of caspase 3/7 activity. Widely present in the roots of Glycyrrhiza uralensis, Glycyrrhiza inflata and Glycyrrhiza glabra, Neoliquiritin can be applied to studies on human oral squamous cell carcinoma, leukemia, Parkinson's disease and other conditions .

Glabrone 1 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	PPAR Influenza Virus
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .

Licraside	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	FXR Factor Xa
Licraside, found in Glycyrrhiza glabra, is a Farnesoid X receptor (FXR) activator. Licraside activates FXR to induce upregulation of SHP and BSEP, regulates bile acid homeostasis, reduces elevated biliary and serum TBA, serum ALT, AST, GGT, ALP, and TBIL levels, and attenuates liver histopathological damage. Licraside inhibits factor Xa with an IC₅₀ of 48.54 mM. Licraside can be used for the research of cholestasis and thromboembolic diseases .

Glycyrrhizin-6'-methylester	Triterpenes Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
Glycyrrhizin-6'-methylester is a natural product that can be isolated from licorice (Glycyrrhiza glabra) .

Licoflavanone 3′-Prenylnaringenin	Structural Classification Glycyrrhiza glabra Linn. Flavonoids Leguminosae Flavonones Plants Source Classification	Bacterial mTOR Akt PI3K NF-κB Caspase JNK ERK COX NO Synthase Apoptosis
Licoflavanone (3′-Prenylnaringenin) is a flavanone with antioxidant, anti-inflammatory and anticancer activities. Licoflavanone can be isolated from the leaf extract of Glycyrrhiza glabra. Licoflavanone downregulates the mTOR/PI3K/AKT signaling pathway to inhibit the proliferation, migration and invasion of cancer cells, while activates Bax, Bad and multiple caspase enzymes to induce apoptosis. Its anti-inflammatory effect is manifested by reducing the nuclear translocation of NF-κB, decreasing the phosphorylation levels of p38, JNK and ERK1/2, thereby inhibiting the expression of nitric oxide, proinflammatory cytokines, COX-2 and iNOS. Licoflavanone is used in studies on nasopharyngeal carcinoma and related mechanisms .

Glycyrrhiza glabra extract	Structural Classification Extract	Bacterial
Glycyrrhiza glabra extract is rich in bioactive compounds such as glycyrrhizic acid, glycyrrhetinic acid, flavonoids, and glycyrrhizin, and has antioxidant, anti-inflammatory, antibacterial, and skin-protective effects.

Glucoliquiritin	Flavonoids Leguminosae Plants Other Flavonoids Glycyrrhiza uralensis Fisch. Source Classification	Others
Glucoliquiritin is a Flavonoids product that can be isolated from the roots of Glycyrrhiza glabra L. .

Licoagrochalcone B	Glycyrrhiza glabra Linn. Flavonoids Flavones Leguminosae Plants Source Classification	Others
Licoagrochalcone B is a prenylated retrochalcone that can be found in Glycyrrhiza glabra hairy root cultures .

Kanzonol D	Glycyrrhiza glabra Linn. Flavonoids Flavones Leguminosae Plants Source Classification	Others
Kanzonol D is a flavonoid compound that can be found in the hairy root cultures of Glycyrrhiza glabra .

3,3',5'-Trihydroxy-4-methoxybibenzyl	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Phenols Polyphenols Plants Source Classification	Drug Derivative
3,3',5'-Trihydroxy-4-methoxybibenzyl is a dihydrostilbene derivative that can be found in the leaves of Glycyrrhiza glabra .

2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid	Monophenols Microorganisms Phenols Source Classification	Endogenous Metabolite
2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .

Kanzonol Y	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Phenols Polyphenols Plants Source Classification	Dengue Virus
Kanzonol Y is a chalcone compound that can be found in the roots of Glycyrrhiza glabra. Kanzonol Y exerts anticancer and anti-dengue virus activity .

Licoagrocarpin	Structural Classification Glycyrrhiza glabra Linn. Flavonoids Leguminosae Plants Other Flavonoids Source Classification	Drug Intermediate
Licoagrocarpin is an isoprenylated pterocarpan, a type of naturally occurring flavonoid found in the roots of Glycyrrhiza glabra. Licoagrocarpin serves as a precursor in the biosynthetic pathway of Glabridin (HY-N0393) .

3-Hydroxyglabrol	Structural Classification Flavanonols Glycyrrhiza glabra Linn. Flavonoids Leguminosae Plants Source Classification	Bacterial
3-Hydroxyglabrol is an Antibacterial agent. 3-Hydroxyglabrol can be isolated from Glycyrrhiza glabra L. var. typica. 3-Hydroxyglabrol inhibits the growth of Staphylococcus aureus (ATCC 13709) and Mycobacterium smegmatis (ATCC 607), with a MIC of 6.25 mcg/mL. 3-Hydroxyglabrol can be used for the research of Staphylococcus aureus infection, Mycobacterium smegmatis infection .

Licorice oil	Structural Classification Extract	Bacterial
Licorice oils, derived from the roots and rhizomes of the licorice plant (Glycyrrhiza glabra), are rich in bioactive compounds like glycyrrhizin, flavonoids, and triterpenoid. Licorice oil has anti-inflammatory and antibacterial properties, which can effectively soothe irritated skin, reduce redness, control eczema, and fight acne.

Hispaglabridin B (R)-Hispaglabridin B	Structural Classification Natural Products Glycyrrhiza glabra Linn. Leguminosae Plants Source Classification	FOXO
Hispaglabridin B is an anti-oxidant agent that can be isolated from Glycyrrhiza glabra. Hispaglabridin B exhibits potent peroxynitrite scavenging activity with an IC₅₀ of 3.2 μM, and shows activity in a low-density lipoprotein (LDL) oxidation system . Hispaglabridin B is also a FoxO1 inhibitor . Hispaglabridin B improves muscle wasting by inhibiting catabolism in vivo and in vitro.

Neouralenol	Structural Classification Flavonols Flavonoids Leguminosae Plants Glycyrrhiza uralensis Fisch. Source Classification	Biochemical Assay Reagents Reactive Oxygen Species (ROS)
Neouralenol is a free radical scavenger. Neouralenol can be isolated from licorice roots. Neouralenol scavenges hydroxyl radicals and hydroperoxyl radicals .

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