Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
HAE
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "HAE" in MCE Product Catalog:
Cat. No.: HY-P1232
CAS No.: 64111-99-5
Synonyms: His-Ala-Glu; H-His-Ala-Glu-OH
Target:
Research Areas:
2
1
Target:
Research Areas:
Sebetralstat (KVD900) is an orally active and selective plasma kallikrein inhibitor, with an IC50 of 6.0 nM and a Ki of 3.0 nM against the human target. Sebetralstat binds to the active site of plasma kallikrein, inducing a conformational flip of Trp215 to form a U-shaped conformation; its P1 group interacts with the S1 pocket through hydrophobic interactions and displacement of high-energy water molecules, independent of the Asp189 ionic bond. Sebetralstat inhibits plasma kallikrein-kinin system activation in whole plasma, rapidly relieves laryngeal and abdominal attack symptoms of hereditary angioedema (HAE-C1INH), and reduces attack severity. Sebetralstat can be used in research related to hereditary angioedema (HAE) .
1
1 Cited Publications
Cat. No.: HY-P74412A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ANGPT1; Ang1; Angiopoietin 1; ANG-1; Angiopoietin-1; AGP1; KIAA0003; AGPT; AGPT-1; HAE5
Species:
Mouse
Source:
HEK293
Cat. No.: HY-145949
CAS No.: 2607871-93-0
Target:
Research Areas:
Remdesivir de(ethylbutyl 2-aminopropanoate) is an impurity of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro .
Cat. No.: HY-174224
CAS No.: 438196-25-9
Synonyms: ZINC000002782982
Amb929 (ZINC000002782982), a nsp3 ligand, is an anti-SARS-CoV-2 agent. Amb929 inhibits SARS-CoV2-mNG replication in VeroE6 cells with an EC50 of 34.7 µM. Amb929 has limited and moderate cytotoxicity for VeroE6 cells (CC50: 281 µM). Amb929 also inhibits SARS-CoV-2-mNG replication in Human Airway Epithelium (HAE) .
Cat. No.: HY-163464
Target:
Research Areas:
Plasma kallikrein-IN-5 (Compound 20) is a potent covalent inhibitor of plasma potassium kinin peptide (Pka) with IC50 values of 66 nM and 70 pM at 1 minute and 24 hours, respectively. Plasma kallikrein-IN-5 can be used IN the study of hereditary angioedema (HAE) .
Cat. No.: HY-P88243A
Synonyms: HAE3; HAEX; HAF
Cat. No.: HY-132830A
CAS No.: 2163789-76-0
Synonyms: KVD900 hydrochloride
Target:
Research Areas:
Sebetralstat hydrochloride (KVD900 hydrochloride) is an orally active and selective plasma kallikrein inhibitor, with an IC50 of 6.0 nM and a Ki of 3.0 nM against the human target. Sebetralstat hydrochloride binds to the active site of plasma kallikrein, inducing a conformational flip of Trp215 to form a U-shaped conformation; its P1 group interacts with the S1 pocket through hydrophobic interactions and displacement of high-energy water molecules, independent of the Asp189 ionic bond. Sebetralstat hydrochloride inhibits plasma kallikrein-kinin system activation in whole plasma, rapidly relieves laryngeal and abdominal attack symptoms of hereditary angioedema (HAE-C1INH), and reduces attack severity. Sebetralstat hydrochloride can be used in research related to hereditary angioedema (HAE) .
Cat. No.: HY-P706307
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANGPT1; Ang1; Angiopoietin 1; ANG-1; Angiopoietin-1; AGP1; KIAA0003; AGPT; AGPT-1; HAE5
Species:
Human
Source:
HEK293
Cat. No.: HY-P700560
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ANGPT1; Ang1; Angiopoietin 1; ANG-1; Angiopoietin-1; AGP1; KIAA0003; AGPT; AGPT-1; HAE5
Species:
Rat
Source:
P. pastoris
Cat. No.: HY-P72189
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: F12; Coagulation Factor XIIa Heavy Chain; Coagulation Factor XII; Coagulation Factor XIIa Light Chain; Hageman Factor; Beta-Factor XIIa Part 1; Plasma Coagulation Factor XIIa; Beta-Factor XIIa Part 2; HAF; HAE3; Coagulation Factor XII (Hageman Factor); HA
Species:
Pig
Source:
E. coli
Cat. No.: HY-P700599
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: F12; Coagulation Factor XIIa Heavy Chain; Coagulation Factor XII; Coagulation Factor XIIa Light Chain; Hageman Factor; Beta-Factor XIIa Part 1; Plasma Coagulation Factor XIIa; Beta-Factor XIIa Part 2; HAF; HAE3; Coagulation Factor XII (Hageman Factor); HA
Species:
Pig
Source:
P. pastoris
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
