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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
HIF-PH
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "HIF-PH" in MCE Product Catalog:
88
88 Publications Verification
Synonyms: Dimethyloxallyl Glycine
Target:
Research Areas:
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
20
Target:
Research Areas:
Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
9
9 Cited Publications
Synonyms: PG-1016548; AKB-6548
Target:
Research Areas:
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
8
Target:
Research Areas:
Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia .
Cat. No.: HY-44809
CAS No.: 1303512-02-8
Target:
Research Areas:
Izilendustat is a potent prolyl hydroxylase inhibitor. Izilendustat competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia .
Cat. No.: HY-15893R
CAS No.: 89464-63-1
Synonyms: Dimethyloxallyl Glycine (Standard)
Research Areas:
DMOG (Standard) is the analytical standard of DMOG. This product is intended for research and analytical applications. DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
Cat. No.: HY-17608R
CAS No.: 960539-70-2
Synonyms: GSK1278863 (Standard)
Research Areas:
Daprodustat (Standard) is the analytical standard of Daprodustat. This product is intended for research and analytical applications. Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
Cat. No.: HY-W747868
CAS No.: 1375799-59-9
Target:
Research Areas:
Molidustat sodium is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat sodium can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat sodium can be utilized in the research of renal anemia .
Cat. No.: HY-101277S1
Synonyms: PG-1016548-13C6; AKB-6548-13C6
Cat. No.: HY-12654R
CAS No.: 1154028-82-6
Synonyms: BAY 85-3934 (Standard)
Research Areas:
Molidustat (Standard) is the analytical standard of Molidustat. This product is intended for research and analytical applications. Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia .
Cat. No.: HY-44809A
CAS No.: 1303513-80-5
Target:
Research Areas:
Izilendustat hydrochloride is a potent prolyl hydroxylase inhibitor. Izilendustat hydrochloride competitively inhibits HIFPH2 activity, blocks HIF-1α degradation, stabilizes HIF-1α and HIF-2α proteins, and upregulates downstream target gene expression. Izilendustat hydrochloride can reduce intestinal inflammation and damage, enhance the ability of phagocytes to clear pathogens, and improve ischemia-related pathological phenotypes. Izilendustat hydrochloride can be used for the research of inflammatory bowel disease, ischemic vascular disease and anemia .
Cat. No.: HY-101277R
CAS No.: 1000025-07-9
Synonyms: PG-1016548 (Standard); AKB-6548 (Standard)
Research Areas:
Vadadustat (Standard) is the analytical standard of Vadadustat (HY-101277). This product is intended for research and analytical applications. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
Cat. No.: HY-P87578
Synonyms: DKFZp434E026 antibody;
Egl nine homolog 2 antibody;
EGLN 2 antibody;
EIT 6 antibody;
Estrogen-induced tag 6 antibody;
HIF P4H 1 antibody;
HIF prolyl hydroxylase 1 antibody;
HIF-PH1 antibody;
HIF-prolyl hydroxylase 1 antibody;
HIFPH 1 antibody;
HPH-3 antibody;
HPH3 antibody;
Hypoxia-inducible factor prolyl hydroxylase 1 antibody;
P4H1 antibody;
PHD 1 antibody;
prolyl hydroxylase domain containing protein 1 antibody
Cat. No.: HY-P703327
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EGLN1; HPH-2; Prev. C1orf12; Hypoxia-Inducible Factor-Proline Dioxygenase; PHD2; Egl-9 Family Hypoxia-Inducible Factor 1; ZMYND6; Egl Nine Homolog 1 (C. Elegans); HIFPH2; EGL Nine (C.Elegans) Homolog 1; SM-20; HIF Prolyl Hydroxylase 2; Prolyl Hydroxylase
Species:
Human
Source:
E. coli
Cat. No.: HY-P706012
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: EGLN1; HPH-2; Prev. C1orf12; Hypoxia-Inducible Factor-Proline Dioxygenase; PHD2; Egl-9 Family Hypoxia-Inducible Factor 1; ZMYND6; Egl Nine Homolog 1 (C. Elegans); HIFPH2; EGL Nine (C.Elegans) Homolog 1; SM-20; HIF Prolyl Hydroxylase 2; Prolyl Hydroxylase
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
