IGFBP3

By Targets:	Autophagy (1) Calcium Channel (2) IGF-1R (2) mRNA (1) NO Synthase (2) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W074890

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Calcium Channel NO Synthase	Neurological Disease Inflammation/Immunology
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA ^[3].

HY-RS06626

IGFBP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IGFBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGFBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IGFBP3 Human Pre-designed siRNA Set A IGFBP3 Human Pre-designed siRNA Set A

HY-110135A

NBI-31772 hydrate 3 Publications Verification	IGF-1R	Neurological Disease
NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (K_is=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects ^[3].

HY-P10403

IGFBP-3 peptide	IGF-1R	Inflammation/Immunology Cancer
IGFBP-3 peptide is a 18-amino acid insulin-like growth factor binding protein-3. IGFBP-3 peptide binds Humanin (HY-P1928) and Hyaluronan (HY-B0633A), blocks the interaction of CD44 and hyaluronan .

HY-174650

*Human IGFBP3* mRNA**	mRNA	Metabolic Disease
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

HY-RS23885

Igfbp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Igfbp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igfbp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Igfbp3 Rat Pre-designed siRNA Set A Igfbp3 Rat Pre-designed siRNA Set A

HY-RS17430

Igfbp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Igfbp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igfbp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Igfbp3 Mouse Pre-designed siRNA Set A Igfbp3 Mouse Pre-designed siRNA Set A

HY-N3316

Martynoside 1 Publications Verification	Others
Martynoside protects ex vivo bone marrow cells from 5-fluorouracil (5-FU)-induced cell death and inflammation response by down-regulating the TNF signaling pathway .Martynoside is a potent antiestrogen in MCF-7 cells, increasing IGFBP3 levels

HY-W074890R

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Reference Standards Calcium Channel NO Synthase	Neurological Disease Inflammation/Immunology
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

HY-182824

Sucrose dilaurate	Autophagy	Others
Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries ^[3] .

Cat. No.	Product Name	Target	Research Area

HY-P10403

IGFBP-3 peptide	IGF-1R	Inflammation/Immunology Cancer
IGFBP-3 peptide is a 18-amino acid insulin-like growth factor binding protein-3. IGFBP-3 peptide binds Humanin (HY-P1928) and Hyaluronan (HY-B0633A), blocks the interaction of CD44 and hyaluronan .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W074890

Palmitoylglycine 1 Publications Verification N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA ^[3].

HY-N3316

Martynoside 1 Publications Verification	Simple Phenylpropanols Labiatae Phenols Polyphenols Calopogonium mucunoides Desv. Phenylpropanoids Plants Source Classification	Others
Martynoside protects ex vivo bone marrow cells from 5-fluorouracil (5-FU)-induced cell death and inflammation response by down-regulating the TNF signaling pathway .Martynoside is a potent antiestrogen in MCF-7 cells, increasing IGFBP3 levels

HY-W074890R

Palmitoylglycine (Standard) N-palmitoyl glycine (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Calcium Channel NO Synthase
Palmitoylglycine (Standard) is the analytical standard of Palmitoylglycine. This product is intended for research and analytical applications. Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA[1][2][3].

Recombinant Proteins Recommended:

IGFBP-3

Species:	Human (4) Mouse (1) Cynomolgus (1)
Tag:	His (2) Tag Free (1) Fc (3)
Source:	HEK293 (5) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703840

	IGFBP-3 Protein, Cynomolgus (HEK293, His) Insulin-like growth factor-binding protein 3; IGF-BP3; IBP-3; IGFBP-3	Cynomolgus	HEK293
	IGFBP-3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IGFBP-3 protein, expressed by HEK293, with N-His tag.

HY-P73138

	IGFBP-3 Protein, Human (HEK293, His) Insulin-like growth factor-binding protein 3; IGF-BP3; IBP-3; IGFBP-3	Human	HEK293
	IGFBP-3 protein is a part of IGFBP that significantly prolongs IGF half-life and modulates growth effects in cell culture. It inhibits or stimulates IGF-induced cellular responses by changing the kinetics of interaction with cell surface receptors. IGFBP-3 Protein, Human (HEK293, His) is the recombinant human-derived IGFBP-3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P7020

	IGFBP-3 Protein, Human rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3	Human	E. coli
	IGFBP-3 Protein, Human belongs to insulin-like growth factor-binding protein, prolongs the half-life of the insulin-like growth factors (IGFs), inhibits interaction of IGFs with their cell surface receptors, and functions in cancer reduction.

HY-P704674

	IGFBP-3 Protein, Human (HEK293, Fc) rHuIGF-BP3; IBP-3; IGF-binding protein 3; IGFBP-3	Human	HEK293
	IGFBP-3 protein is a part of IGFBP that significantly prolongs IGF half-life and modulates growth effects in cell culture. It inhibits or stimulates IGF-induced cellular responses by changing the kinetics of interaction with cell surface receptors. IGFBP-3 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFBP-3 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P77697

	*TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc)* IGFBP-3R; GFBP3R; LOC124446; TMEM219	Mouse	HEK293
	The IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and becomes a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This receptor actively interacts with IGFBP3, forming a key molecular connection that may initiate the apoptotic signaling cascade. TMEM219/IGFBP-3R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77962

	*TMEM219/IGFBP-3R Protein, Human (HEK293, Fc)* IGFBP-3R; GFBP3R; LOC124446; TMEM219	Human	HEK293
	The TMEM219/IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This protein actively binds to IGFBP3, forming a key molecular interaction that may initiate the apoptosis signaling pathway. TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is the recombinant human-derived TMEM219/IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag.

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HY-P87457

	IGFBP3 Antibody (YA7144)	WB	Human
	IGFBP3 Antibody (YA7144) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IGFBP3.

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Cat. No.	Product Name		Classification

HY-RS06626

IGFBP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IGFBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for IGFBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174650

*Human IGFBP3* mRNA**		mRNA
Human IGFBP3 mRNA encodes the human insulin like growth factor binding protein 3 (IGFBP3) protein, a member of the insulin-like growth factor binding protein (IGFBP) family. IGFBP3 can form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors.

HY-RS23885

Igfbp3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Igfbp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igfbp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17430

Igfbp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Igfbp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igfbp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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