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Isoforms Recommended:	IL-17

Results for "

IL17A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (76) Adenosine Deaminase (1) Androgen Receptor (1) Apoptosis (4) Aryl Hydrocarbon Receptor (1) Bacterial (1) Biochemical Assay Reagents (1) Caspase (1) CXCR (2) Cytochrome P450 (1) DNA/RNA Synthesis (2) Epigenetic Reader Domain (1) Ferroptosis (1) FGFR (1) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) Glutathione Peroxidase (2) Glutathione S-transferase (2) Histone Acetyltransferase (1) IFNAR (7) JAK (2) Keap1-Nrf2 (2) Lipocalin Family (2) Lipoxygenase (1) Mitophagy (1) MMP (2) mRNA (1) Necroptosis (1) NF-κB (3) NO Synthase (1) Notch (2) p38 MAPK (1) PARP (2) Phosphodiesterase (PDE) (1) PINK1/Parkin (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) ROR (11) Small Interfering RNA (siRNA) (4) SOD (2) STAT (3) TGF-beta/Smad (1) TNF Receptor (7) Toll-like Receptor (TLR) (1) VEGFR (1) Wnt (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (88) Metabolic Disease (4) Neurological Disease (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) Interleukin & Receptors (1) siRNAs (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99280

Bimekizumab 1 Publications Verification CDP4940; UCB-4940	Interleukin Related	Inflammation/Immunology
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises *IL-17A* and *IL-17F*. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation .

HY-15826

SGC-CBP30 Maximum Cited Publications 20 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Inflammation/Immunology Cancer
SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (K_ds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects .

HY-139206

LY3509754 4 Publications Verification IL-17A inhibitor 1	Interleukin Related	Inflammation/Immunology
LY3509754 (IL-17A inhibitor 1) is a *IL-17A* inhibitor, with IC₅₀ values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells .

HY-P9927

Secukinumab Maximum Cited Publications 8 Publications Verification AIN457	Interleukin Related	Inflammation/Immunology Cancer
Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .

HY-P9924

Ixekizumab LY2439821	Interleukin Related	Inflammation/Immunology
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin *IL-17A* (K_D<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .

HY-177129

Simepdekinra LY4100511; DC-853	Interleukin Related	Inflammation/Immunology
Simepdekinra (LY4100511; DC-853) is an *IL-17A* antagonist. Simepdekinra can be used in the research of moderate to severe plaque-type psoriasis .

HY-101913

IL-17A antagonist 1 3 Publications Verification	Interleukin Related	Neurological Disease Inflammation/Immunology
IL-17A antagonist 1 (Compound 1) is an *IL-17A* antagonist, with a K_d of 0.66 μM and an IC₅₀ of 1.14 μM .

HY-P990222

*Anti-Mouse/Rat IL-17A* Antibody (17F3)** 1 Publications Verification	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat *IL-17A. Anti-Mouse IL-17A* Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes .

HY-P9927A

*Secukinumab (Anti-Human IL-17A)* 1 Publications Verification	Interleukin Related	Inflammation/Immunology Cancer
Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis .

HY-P1924

IRBP(651-670) human, mouse	Lipocalin Family Interleukin Related	Inflammation/Immunology
IRBP (651-670) human, mouse is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, *IL-17A* and *IL-17F). IRBP (651-670) human, mouse is a IRBP* fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse induces experimental autoimmune uveitis. IRBP (651-670) human, mouse is applicable to research related to experimental autoimmune uveitis .

HY-153780

Navepdekinra DC-806; LY4100504; S-011806	Interleukin Related	Inflammation/Immunology
Navepdekinra (DC-806) is an orally active, potent interleukin-17A (IL-17A) inhibitor (IC₅₀ = 10.81 nM). Navepdekinra disrupts the IL-17A protein-receptor interaction, suppressing the downstream pro-inflammatory signaling pathway. Navepdekinra inhibits arthritis in a collage-induced arthritis (CIA) rat model. Navepdekinra can be used for psoriasis, psoriatic arthritis, and ankylosing spondylitis .

HY-P99335

Vunakizumab Anti-Human IL17A Recombinant Antibody; SHR-1314	Interleukin Related	Inflammation/Immunology
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody and an *Interleukin-17A* (IL-17A) inhibitor. Vunakizumab binds to IL-17A to inhibit downstream cytokines and block inflammatory signaling. Vunakizumab can be used for the research of chronic plaque psoriasis and ankylosing spondylitis .

HY-141692

IL-17 modulator 4	Interleukin Related	Inflammation/Immunology Cancer
IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome .

HY-N3029

Noreugenin 2 Publications Verification	Interleukin Related Apoptosis Glutathione Peroxidase SOD Glutathione S-transferase Necroptosis	Inflammation/Immunology
Noreugenin is a phenolic compound found in Calea uniflora Less. Noreugenin inhibits myeloperoxidase activity and reduces levels of proinflammatory cytokines IL-1β and *IL-17A* levels in LPS (HY-D1056)-induced murine pleurisy model. Noreugenin reduces apoptosis and necrosis. Noreugenin reduces lipid peroxidation, and antioxidant enzyme (CAT, SOD, GST) activity. Noreugenin exhibits anti-inflammatory and antioxidant effects. Noreugenin can be used for the research of inflammatory conditions, such as pleurisy .

HY-P99754

Netakimab BCD-085	Interleukin Related	Infection Inflammation/Immunology
Netakimab (BCD-085) is a humanized IgG1κ monoclonal anti-IL-17 antibody that binds to and blocks *IL-17* and *IL-17A* activity, including reduction of downstream IL-6 production. Netakimab can be used for the research of moderate-to-severe plaque psoriasis, ankylosing spondylitis, and COVID-19 with cytokine release syndrome . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99424

Afasevikumab RG 7624; RO 5553110; NI-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-139780

JNJ-61803534	ROR	Inflammation/Immunology
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC₅₀ of 9.6 nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions .

HY-107390A

AX-024 hydrochloride 3 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and *IL-17A*.

HY-107390

AX-024 3 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and *IL-17A*.

HY-P990741

Galvokimig UCB-9741	Interleukin Related	Inflammation/Immunology
Galvokimig is an anti-IL13/IL17A/ALB/IL17B monoclonal antibody .

HY-P99515

Xeligekimab GR 1501	Interleukin Related	Inflammation/Immunology
Xeligekimab (GR 1501) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab inhibits the pro-inflammatory cascade. Xeligekimab can be used for the research of inflammatory disease, such as radiographic axial spondyloarthritis .

HY-P99563

Tibulizumab LY 3090106	TNF Receptor Interleukin Related	Inflammation/Immunology
Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research .

HY-145429

IL-17A modulator-2 2 Publications Verification	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
IL-17A modulator-2 is a *IL-17A* modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC₅₀ of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .

HY-P99652

Gumokimab AK 111	Interleukin Related	Inflammation/Immunology
Gumokimab (AK 111) is a monoclonal antibody targeting *IL-17A, which can be used in the study of psoriasis, ankylosing spondylitis. Gumokimab competitively blocks the binding of human IL-17A* to *IL-17R*.

HY-P3450

Erepdekinra	Interleukin Related	Inflammation/Immunology
Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist .

HY-145430

IL-17A modulator-1	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
IL-17A modulator-1 is a *IL-17A* modulator, extracted from patent WO2021239743+A1, example 9. IL-17A modulator-1 inhibits the biological action of IL-17A with a pIC₅₀ of 8.2. IL-17A modulator-1 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders .

HY-148272

IL-17A modulator-3	Interleukin Related	Inflammation/Immunology Cancer
IL-17A modulator-3 (compound 253) is a *IL-17A* modulator. IL-17A modulator-3 inhibits IL-17A/A with an IC₅₀ value ＜10 μM. IL-17A modulator-3 can be used for the research of inflammation, cancer and autoimmune disease .

HY-N0902

Dihydrosanguinarine 13,14-Dihydrosanguinarine	Fungal Bacterial Interleukin Related	Infection Inflammation/Immunology
Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the *TNF/IL-17/PI3K* signaling pathway, downregulates the levels of pro-inflammatory factors such as *IL-17A, TNF-α* and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis .

HY-P99310

Perakizumab RG4934	Interleukin Related	Inflammation/Immunology
Perakizumab (RG4934) is a humanized IgG1κ monoclonal antibody against *IL-17A* (Interleukin Related). Perakizumab can be uesd for the research of autoimmune diseases, such as psoriatic arthritis .

HY-119464

MRL-871 1 Publications Verification	ROR	Cancer
MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC₅₀ of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .

HY-101915

IL-17A antagonist 3	Interleukin Related	Inflammation/Immunology
IL-17A antagonist 3 is an *IL-17A* antagonist, compound 3 .

HY-139686

IL-17A inhibitor 2	Interleukin Related	Inflammation/Immunology
IL-17A inhibitor 2 is an *IL-17A* inhibitor for researching psoriasis, rheumatoid arthritis, and multiple sclerosis.

HY-155830

Morcamilast ME3183; PDE4-IN-14	Phosphodiesterase (PDE) Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Morcamilast (ME3183) is a selective and orally active PDE4 inhibitor, with IC₅₀s of 1.28 nM (PDE4A1A), 2.33 nM (PDE4B1), and 1.63 nM (PDE4D2) respectively. Morcamilast shows weak inhibition of PDEs other than PDE4s Morcamilast is an anti-inflammatory agent and inhibits LPS (HY-D1056)-induced release of TNF-α, IL-12/23p40, IL-23, and *IL-17A* in human PBMCs and T cells. Morcamilast has antipruritic effect and can be used in the study of psoriasis, atopic dermatitis, and other inflammatory diseases .

HY-164826

Acetyl zingerone	Interleukin Related Reactive Oxygen Species (ROS) MMP Pyroptosis Ferroptosis Notch Keap1-Nrf2 PINK1/Parkin Mitophagy Caspase Apoptosis	Inflammation/Immunology Cancer
Acetyl zingerone is an analog of Zingerone (HY-14621). Acetyl zingerone downregulates the expression of ROS metabolism-related genes, fibroblast senescence-related genes, keratinocyte differentiation-related genes, and *IL-17A* target genes. Acetyl zingerone inhibits the activities of MMP-1, MMP-3, and MMP-12, as well as the activation of NLRP3 inflammasome, pyroptosis (pyroptosis), ferroptosis (ferroptosis), cartilage destruction, and UVA-induced cyclobutane pyrimidine dimer formation. Acetyl zingerone upregulates the expression of collagen, proteoglycan, extracellular matrix glycoprotein, Notch pathway, and GPX4 gene, activates Nrf2 and HO-1, induces extracellular matrix synthesis and PINK1/Parkin-mediated mitophagy (mitophagy), and promotes chondrocyte survival. Acetyl zingerone alleviates the progression of osteoarthritis in mice . Acetyl zingerone can be used in research related to skin aging, inflammatory skin diseases, osteoarthritis, melanoma, and non-melanoma skin cancer .

HY-103637

Vimirogant VTP-43742	ROR	Inflammation/Immunology
Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; *IC₅₀*=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC₅₀=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research .

HY-P1924A

IRBP(651-670) human, mouse TFA	Lipocalin Family Interleukin Related	Inflammation/Immunology
IRBP (651-670) human, mouse TFA is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse TFA increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, *IL-17A* and *IL-17F). IRBP (651-670) human, mouse TFA is a IRBP* fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse TFA induces experimental autoimmune uveitis. IRBP (651-670) human, mouse TFA is applicable to research related to experimental autoimmune uveitis .

HY-P991797

*Anti-Mouse IL-17A* Antibody (BZN035)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-17A Antibody (BZN035) targets mouse IL-17A that can neutralize IL-17 in mice. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-RS06697

Il17a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il17a Rat Pre-designed siRNA Set A contains three designed siRNAs for Il17a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il17a Rat Pre-designed siRNA Set A Il17a Rat Pre-designed siRNA Set A

HY-RS06696

Il17a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il17a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il17a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il17a Mouse Pre-designed siRNA Set A Il17a Mouse Pre-designed siRNA Set A

HY-RS06695

IL17A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL17A Human Pre-designed siRNA Set A contains three designed siRNAs for IL17A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL17A Human Pre-designed siRNA Set A IL17A Human Pre-designed siRNA Set A

HY-174633

*Human IL17A* mRNA**	mRNA	Inflammation/Immunology
Human IL17A mRNA encodes the human interleukin 17A (IL17A) protein, a member of the IL-17 receptor family. IL17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer.

HY-133128

FM26	ROR	Cancer
FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC₅₀ of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .

HY-158159

IL17A-IN-1	Interleukin Related	Inflammation/Immunology Cancer
IL17A-IN-1 (compound 72) is an orally active Interleukin 17A inhibitor. IL17A-IN-1 can be used in the study of inflammatory and autoimmune diseases (plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis, etc.), as well as cancer .

HY-126252

A-9758	ROR Interleukin Related	Inflammation/Immunology
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC₅₀=5 nM), and exhibits robust potency against *IL-17A* release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation .

HY-169306

IL-17A inhibitor 4	Interleukin Related	Inflammation/Immunology
IL-17A inhibitor 4 (Example 449) is a potent *IL-17A* inhibitor. IL-17A inhibitor 4 inhibits HTRF and NHK cells viability with IC₅₀s of 0.028 and 0.0047 μM, respectively .

HY-103637A

Vimirogant hydrochloride 1 Publications Verification VTP-43742 hydrochloride	ROR	Inflammation/Immunology
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; *IC₅₀*=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC₅₀=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research .

HY-155244

12R-LOX-IN-2	Lipoxygenase DNA/RNA Synthesis	Inflammation/Immunology
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases .

HY-147128

PY109	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
PY109 is an orally active and highly selective aryl hydrocarbon receptor (AHR) agonist. PY109's EC₅₀ values in human-derived HepG2 and mouse Hepa-1c1c7 cells are 1.2 nM and 1.4 nM respectively. PY109 significantly upregulates the expression of CYP1A1 and IL-22, and inhibits the expression of IL-17A. PY109 significantly improves colitis in mice. PY109 can be used for research on colitis .

HY-W145695

Chitoheptaose	Biochemical Assay Reagents Apoptosis Interleukin Related IFNAR	Cardiovascular Disease Inflammation/Immunology
Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, *IL-17A* and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis .

HY-P991091

COVA322	TNF Receptor Interleukin Related	Inflammation/Immunology
COVA322 is a bispecific TNF and *IL-17A* antibody. COVA322 inhibits simultaneously TNF and the IL-17A homodimer that can be used for the study of inflammatory diseases .

Cat. No.	Product Name	Type

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis .

Cat. No.	Product Name	Target	Research Area

HY-P1924

IRBP(651-670) human, mouse	Lipocalin Family Interleukin Related	Inflammation/Immunology
IRBP (651-670) human, mouse is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, *IL-17A* and *IL-17F). IRBP (651-670) human, mouse is a IRBP* fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse induces experimental autoimmune uveitis. IRBP (651-670) human, mouse is applicable to research related to experimental autoimmune uveitis .

HY-P3450

Erepdekinra	Interleukin Related	Inflammation/Immunology
Erepdekinra is an interleukin-17A (IL-17A) receptor antagonist .

HY-P1924A

IRBP(651-670) human, mouse TFA	Lipocalin Family Interleukin Related	Inflammation/Immunology
IRBP (651-670) human, mouse TFA is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse TFA increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, *IL-17A* and *IL-17F). IRBP (651-670) human, mouse TFA is a IRBP* fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse TFA induces experimental autoimmune uveitis. IRBP (651-670) human, mouse TFA is applicable to research related to experimental autoimmune uveitis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99280

Bimekizumab 1 Publications Verification CDP4940; UCB-4940	Interleukin Related	Inflammation/Immunology
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises *IL-17A* and *IL-17F*. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation .

HY-P9927

Secukinumab Maximum Cited Publications 8 Publications Verification AIN457	Interleukin Related	Inflammation/Immunology Cancer
Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .

HY-P9924

Ixekizumab LY2439821	Interleukin Related	Inflammation/Immunology
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin *IL-17A* (K_D<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .

HY-P990222

*Anti-Mouse/Rat IL-17A* Antibody (17F3)** 1 Publications Verification	Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1κ type antibody inhibitor, targeting to mouse and rat *IL-17A. Anti-Mouse IL-17A* Antibody (17F3) can neutralize IL-17. Anti-Mouse/Rat IL-17A Antibody (17F3) can be used for the researches of infection, immunology and metabolic disease, such as M.intracellulare infection and diabetes .

HY-P9927A

*Secukinumab (Anti-Human IL-17A)* 1 Publications Verification	Interleukin Related	Inflammation/Immunology Cancer
Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis .

HY-P99335

Vunakizumab Anti-Human IL17A Recombinant Antibody; SHR-1314	Interleukin Related	Inflammation/Immunology
Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody and an *Interleukin-17A* (IL-17A) inhibitor. Vunakizumab binds to IL-17A to inhibit downstream cytokines and block inflammatory signaling. Vunakizumab can be used for the research of chronic plaque psoriasis and ankylosing spondylitis .

HY-P99754

Netakimab BCD-085	Interleukin Related	Infection Inflammation/Immunology
Netakimab (BCD-085) is a humanized IgG1κ monoclonal anti-IL-17 antibody that binds to and blocks *IL-17* and *IL-17A* activity, including reduction of downstream IL-6 production. Netakimab can be used for the research of moderate-to-severe plaque psoriasis, ankylosing spondylitis, and COVID-19 with cytokine release syndrome . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99424

Afasevikumab RG 7624; RO 5553110; NI-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-P990741

Galvokimig UCB-9741	Interleukin Related	Inflammation/Immunology
Galvokimig is an anti-IL13/IL17A/ALB/IL17B monoclonal antibody .

HY-P99515

Xeligekimab GR 1501	Interleukin Related	Inflammation/Immunology
Xeligekimab (GR 1501) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab inhibits the pro-inflammatory cascade. Xeligekimab can be used for the research of inflammatory disease, such as radiographic axial spondyloarthritis .

HY-P99563

Tibulizumab LY 3090106	TNF Receptor Interleukin Related	Inflammation/Immunology
Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research .

HY-P99652

Gumokimab AK 111	Interleukin Related	Inflammation/Immunology
Gumokimab (AK 111) is a monoclonal antibody targeting *IL-17A, which can be used in the study of psoriasis, ankylosing spondylitis. Gumokimab competitively blocks the binding of human IL-17A* to *IL-17R*.

HY-P99310

Perakizumab RG4934	Interleukin Related	Inflammation/Immunology
Perakizumab (RG4934) is a humanized IgG1κ monoclonal antibody against *IL-17A* (Interleukin Related). Perakizumab can be uesd for the research of autoimmune diseases, such as psoriatic arthritis .

HY-P991797

*Anti-Mouse IL-17A* Antibody (BZN035)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-17A Antibody (BZN035) targets mouse IL-17A that can neutralize IL-17 in mice. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P991091

COVA322	TNF Receptor Interleukin Related	Inflammation/Immunology
COVA322 is a bispecific TNF and *IL-17A* antibody. COVA322 inhibits simultaneously TNF and the IL-17A homodimer that can be used for the study of inflammatory diseases .

HY-P991725

Velvakiment ZL-1102	Interleukin Related	Inflammation/Immunology
Velvakiment is a humanized VHH nanobody that targets IL-17A. Velvakiment can be used for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis research .

HY-P991129

Crusekitug QX-002N	Interleukin Related	Inflammation/Immunology
Crusekitug is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A). Crusekitug specifically binds to *IL-17A*, blocking its signal transduction, thus exerting immunosuppressive and anti-inflammatory activities. Crusekitug is promising for research of autoimmune and inflammatory diseases, such as psoriasis and rheumatoid arthritis .

HY-P991146

Lecankitug LZM-012; XKH004	Interleukin Related	Inflammation/Immunology
Lecankitug is a humanized monoclonal antibody targeting human interleukin 17A (IL-17A) and interleukin 17F (IL-17F). Lecankitug specifically binds to *IL-17A* and *IL-17F*, blocking their signal transduction, thus exerting immunosuppressive and anti-inflammatory activities. Lecankitug is promising for research of autoimmune and inflammatory diseases, such as psoriasis and rheumatoid arthritis .

HY-P991116

Amdokitug SSGJ-608	Interleukin Related	Inflammation/Immunology
Amdokitug is an anti-IL17A human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991260

CNTO-6785	Interleukin Related	Infection
CNTO-6785 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). CNTO-6785 is promising for research of chronic obstructive pulmonary disease (COPD) .

HY-P991263

SCH-900117	Interleukin Related	Inflammation/Immunology
SCH-900117 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). SCH-900117 is promising for research of autoimmune diseases such as psoriasis and rheumatoid arthritis .

HY-P990761

Roconkibart JS-005	Interleukin Related	Inflammation/Immunology
Roconkibart is an anti-IL17A human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P990973

Betinukibart	Interleukin Related	Inflammation/Immunology
HY-P990973 is an *IL17A*-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991595

HB-0017	Interleukin Related	Inflammation/Immunology
HB-0017 is a humanized IgG1κ monoclonal antibody inhibitor, targeting *IL-17A. HB-0017 inhibits the IL-6 secretion induced by IL-17A* with an IC₅₀ of 2.09 nM. HB-0017 significantly decreases ear thickness in Imiquimod (HY-B0180)-induced psoriasis-like mice model and alleviates inflammations in IL-17A-induced arthritis and air pouch mice model. The isotype control for the HB-0017 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P991261

CJM-112	Interleukin Related	Inflammation/Immunology
CJM-112 is a humanized monoclonal antibody inhibitor targeting interleukin-17A (IL-17A). CJM-112 is promising for research of inflammatory diseases, such as hidradenitis suppurativa associated with abnormal IL-17A-related pathways .

HY-P990252

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and *IL-17A* production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma .

HY-P992045

HZD37-5	Interleukin Related CXCR	Inflammation/Immunology
HZD37-5 is a humanized monoclonal antibody specifically recognizing N78 loci of *IL-17A. HZD37-5 binds to human and rhesus monkeys, blocks IL-17 induced signal transduction and the release of IL-6, IL-8, CXCL-1* and GM-GSF. HZD37-5 significantly inhibited human IL-17A induced-keratinocyte chemoattractant secretion. HZD37-5 can be used for the research of autoimmune diseases including psoriasis and psoriatic arthritis .

HY-P991035

Turenkibart	Interleukin Related	Inflammation/Immunology
HY-P991035 is an *IL17A*-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P992101

Aritinercept AUR-200	TNF Receptor IFNAR Interleukin Related	Inflammation/Immunology
Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, *IL-17A*, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus .

HY-P990386

*Anti-CTLA-8/IL-17a* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-CTLA-8/IL-17a Antibody is a human antibody expressed in CHO, targeting *CTLA-8/IL-17a. The Anti-CTLA-8/IL-17a* Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CTLA-8/IL-17a Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

IL-17A

Species:	Human (12) Marmoset (1) Rhesus Macaque (2) Rat (2) Mouse (9) Cynomolgus (2) Rabbit (3) Pig (2) Canine (2)
Tag:	His (21) Strep (1) Tag Free (12) Avi (6) Myc (1) Fc (1)
Source:	HEK293 (15) CHO (4) Sf9 insect cells (4) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73175A

	IL-17A Protein, Rabbit CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Rabbit	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rabbit is a recombinant rabbit IL-17A protein and is expressed in E. coli. It consists of 130 amino acids (G24-A153).

HY-P73170

	IL-17A Protein, Canine CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Canine	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Canine is a recombinant canine IL-17A protein and is expressed in E. coli. It consists of 130 amino acids (G26-A155).

HY-P76418

	IL-17A Protein, Marmoset Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Marmoset	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Marmoset is a recombinant marmoset IL-17A protein is expressed in E. coli. It consists of 134 amino acids (I20-A153).

HY-P73174

	IL-17A Protein, Mouse (solution) Maximum Cited Publications 8 Publications Verification CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Mouse	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (solution) is a recombinant mouse IL-17A protein and is expressed in E. coli. It consists of 137 amino acids (T22-A158).

HY-P73175

	IL-17A Protein, Rabbit (solution) 1 Publications Verification CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Rabbit	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rabbit (solution) is a recombinant rabbit IL-17A protein and is expressed in E. coli. It consists of 130 amino acids (G24-A153).

HY-P73171

	IL-17A Protein, Human (CHO) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Human	CHO
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (CHO) is a recombinant human IL-17A protein and is expressed in CHO cells. It consists of 155 amino acids (M1-A155).

HY-P74833

	IL-17A Protein, Cynomolgus (sf9) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Cynomolgus	Sf9 insect cells
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Cynomolgus (sf9) is a recombinant cynomolgus IL-17A protein and is expressed in sf9 insect cells. It consists of 155 amino acids (M1-A155).

HY-P78556

	IL-17A Protein, Rat (His) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Rat	E. coli
	The IL-17A protein has important heterodimerization and homodimerization activities and is involved in a variety of processes, including responses to glucocorticoid stimulation and the regulation of cell death and transcription. IL-17A is present in the cytoplasm and extracellular space and has been implicated in diseases such as pancreatitis, inflammatory bowel disease, renal disease, and periodontal disease, and may serve as a biomarker. IL-17A Protein, Rat is the recombinant rat-derived IL-17A protein, expressed by E. coli.

HY-P704386

	IL-17A Protein, Human (HEK293) Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Human	HEK293
	The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. IL-17A Protein, Human (HEK293) is the recombinant human-derived IL-17A protein, expressed by HEK293, with tag free.

HY-P700246AF

	*Animal-Free IL-17A* Protein, Pig (His)** Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Pig	E. coli
	IL-17A Protein, part of the IL-17 family, is highlighted. Animal-Free IL-17A Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70753

	IL-17A Protein, Mouse (HEK293, His) 3 Publications Verification Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Mouse	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (HEK293, His) is a recombinant mouse IL-17A protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 137 amino acids (T22-A158).

HY-P73176

	IL-17A Protein, Rabbit (sf9, His) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Rabbit	Sf9 insect cells
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rabbit (sf9, His) is a recombinant rabbit IL-17A protein with His tag at the N-terminus and is expressed in sf9 insect cells. It consists of 130 amino acids (G24-A153).

HY-P73177

	IL-17A Protein, Rhesus macaque (sf9) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Rhesus Macaque	Sf9 insect cells
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Rhesus macaque (sf9) is a recombinant rhesus macaque IL-17A protein and is expressed in sf9 insect cells.

HY-P704695

	IL-17A Protein, Canine (HEK293, His) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Canine	HEK293
	IL-17A Protein, Canine (HEK293, His) is the recombinant canine-derived IL-17A protein, expressed by HEK293, with N-His tag.

HY-P700194AF

	*Animal-Free IL-17A* Protein, Mouse (His)** 3 Publications Verification CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Mouse	E. coli
	IL-17A protein is an important effector cytokine that activates the NF-kappa-B and MAPkinase pathways through the IL17RA-IL17RC receptor complex to protect host tissues from microbial threats. As a key Th17 cytokine, IL-17A mediates neutrophil activation, chemotaxis, and contributes to germinal center formation. Animal-Free IL-17A Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70527

	IL-17A Protein, Human (HEK293, His) 5+ Cited Publications Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Human	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (HEK293, His) is a recombinant human IL-17A protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 132 amino acids (G24-A155).

HY-P72772

	IL-17A Protein, Cynomolgus (HEK293, His) Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Cynomolgus	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-17A protein with His tag at the C-terminus and is expressed in HEK293 cells. It consists of 132 amino acids (G24A155).

HY-P73172

	IL-17A Protein, Human (T26A, sf9, His) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Human	Sf9 insect cells
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (sf9, His) is a recombinant human IL-17A protein with His tag at the N-terminus and is expressed in sf9 insect cells. It consists of 132 amino acids (G24-A155).

HY-P78320

	IL-17A Protein, Mouse (HEK293, His-Avi) CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A	Mouse	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (HEK293, His-Avi) is a recombinant mouse IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (A26-A158).

HY-P78158

	IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A	Mouse	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 133 amino acids (A26-A158).

HY-P78157

	IL-17A Protein, Human (Biotinylated, HEK293, His-Avi) CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A	Human	HEK293
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IL-17A protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells.

HY-P79326

	IL-17A Protein, Rat (CHO) 3 Publications Verification IL17A; interleukin 17A; IL17; IL-17; CTLA-8; IL-17A; interleukin-17A; Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); cytotoxic T-lymphocyte-associated antigen 8; Interleukin 17	Rat	CHO
	The IL-17A protein has important heterodimerization and homodimerization activities and is involved in a variety of processes, including responses to glucocorticoid stimulation and the regulation of cell death and transcription. IL-17A is present in the cytoplasm and extracellular space and has been implicated in diseases such as pancreatitis, inflammatory bowel disease, renal disease, and periodontal disease, and may serve as a biomarker. IL-17A Protein, Rat (CHO) is the recombinant rat-derived IL-17A protein, expressed by CHO , with tag free.

HY-P73174A

	IL-17A Protein, Mouse (E. coli) CTLA8; CTLA-8; IL-17; Interleukin-17A; IL17A	Mouse	E. coli
	IL-17A protein is an important effector cytokine that activates the NF-kappa-B and MAPkinase pathways through the IL17RA-IL17RC receptor complex to protect host tissues from microbial threats. As a key Th17 cytokine, IL-17A mediates neutrophil activation, chemotaxis, and contributes to germinal center formation. IL-17A Protein, Mouse (E. coli) is the recombinant mouse-derived IL-17A protein, expressed by E. coli , with tag free.

HY-P7372

	IL-17A Protein, Mouse (CHO) 2 Publications Verification rMuIL-17A; CTLA-8; IL-17A	Mouse	CHO
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Mouse (CHO) is a recombinant mouse IL-17A protein and is expressed in CHO cells. It consists of 133 amino acids (A26-A158).

HY-P74832

	IL-17A/F Heterodimer Protein, Rhesus Macaque (HEK293, His) CTLA-8; IL-17; Interleukin-17A; IL17A; Interleukin-17F; IL-17F; Cytokine ML-1	Rhesus Macaque	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F.IL-17A/F Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant rhesus macaque IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells.

HY-P7373

	IL-17A Protein, Human (CHO, His) 2 Publications Verification rHuIL-17A, His; CTLA-8; IL-17A	Human	CHO
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human (CHO, His) is a recombinant human IL-17A protein with His tag at the C-terminus and is expressed in CHO cells. It consists of 132 amino acids (G24-A155).

HY-P700632

	IL-17A Protein, Pig (N-His, C-Myc) Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8; CTLA-8; IL17A; CTLA8; IL17	Pig	E. coli
	In summary, IL-17A participates in multiple immune responses and plays a critical role in maintaining epithelial barrier integrity, promoting neutrophil recruitment, and enhancing host defense against bacterial, fungal, and viral infections. IL-17A Protein, Pig (N-His, C-Myc) is the recombinant pig-derived IL-17A protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P7036

	IL-17A Protein, Human 5+ Cited Publications rHuIL-17; IL-17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8	Human	E. coli
	IL-17A is a homodimeric cytokine and plays a critical role in host defense mechanisms against many bacterial and fungal pathogens as well as allergic and autoimmune responses. IL-17A induces the production of antimicrobial peptides, cytokines, chemokines, and matrix metalloproteinases. IL-17A Protein, Human is a recombinant human IL-17A protein and is expressed in E. coli. It consists of 137 amino acids (I19-A155).

HY-P77707

	IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi) IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F	Mouse	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi) is a recombinant mouse IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells.

HY-P77708

	IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F	Mouse	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant mouse IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells.

HY-P77713

	IL-17A/F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) IL-17A; Interleukin-17A; CTLA-8; IL-17; IL-17F; IL24; ML-1; Interleukin-17F	Human	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A/F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human IL-17A-17F heterodimer protein with His tag and Avi tag at the C-terminus and is expressed in HEK293 cells.

HY-P700104AF

	*Animal-Free IL-17A* Protein, Human (His)** Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8	Human	E. coli
	The IL-17A protein is an important effector cytokine that is critical in both innate and adaptive immunity to defend against microorganisms and maintain tissue integrity. It acts through the IL17RA-IL17RC heterodimeric receptor complex, triggering signaling pathways, activating immune-related gene transcription and promoting strong immune inflammation. Animal-Free IL-17A Protein, Human (His) is the recombinant human-derived animal-FreeIL-17A protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P72589

	IL-17A/F Heterodimer Protein, Human (HEK293, His) IL-17A/F Heterodimer; IL-17A&IL-17F Heterodimer	Human	HEK293
	IL-17A-17F Heterodimer Protein is the heterodimer of the cytokines IL-17A and IL-17F. Both IL-17A and IL-17F can induce antimicrobial peptides, cytokines (IL-6 and GM-CSF), chemokines (CCL2, CCL7 and CXCL1), and matrix metalloproteinases (MMP-1 and MMP13). IL-17A-17F shows intermediate biological activity between IL-17A and IL-17F. IL-17A/F Heterodimer Protein, Human (HEK293, His) is a recombinant human IL-17A-17F heterodimer protein with His tag at the C-terminus and is expressed in HEK293 cells.

HY-P704385

	IL-17A/F Heterodimer Protein, Human (HEK293, Twin Strep, His) IL-17A/F Heterodimer; IL-17A&IL-17F Heterodimer	Human	HEK293

HY-P71963

	IL-17RA Protein, Human (HEK293, hFc) 1 Publications Verification CANDF5; CD217; CD217 antigen; CDw217; CTLA8; HIL 17R; hIL17R; I17RA_HUMAN; IL 17 receptor A; IL 17 receptor; IL 17RA; IL-17 receptor A; IL-17RA; IL17; IL17A receptor; IL17R; IL17RA; IMD51; Interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262	Human	HEK293
	IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F. IL-17RA Protein, Human (HEK 293, hFc) is produced in HEK293 cells with a C-Terminal hFc-tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (2)
Application:	IHC-P (1) ICC/IF (2) IP (1) IHC-F (1) WB (2) ELISA (4)
Isotype:	IgG (1) IgG1 (2) IgG, Kappa (1)
Conjugation:	Non-conjugated (4) Biotin (4)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

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HY-P88057

	IL-17A Antibody (YA7741) CTLA-8; IL-17; IL-17A; IL17; ILA17	ELISA	Human
	IL-17A Antibody (YA7741) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-17A.

HY-P87889

	IL-17A Antibody (YA7574)	WB, ICC/IF, IP, ELISA	Mouse
	IL-17A Antibody (YA7574) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to IL-17A.

HY-P88057A

	IL-17A Antibody (YA7741)(PBS only) CTLA-8; IL-17; IL-17A; IL17; ILA17	ELISA	Human
	IL-17A Antibody (YA7741) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-17A.

HY-P81114

	IL17A Antibody 2 Publications Verification Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN; IL17_MOUSE.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Mouse, Rat
	IL17A Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL17A.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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