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Results for "

IRF5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (1) COX (1) Endogenous Metabolite (1) IFNAR (3) Interleukin Related (1) JNK (1) Lipoxygenase (1) Molecular Glues (1) NO Synthase (1) Small Interfering RNA (siRNA) (3) STAT (1) TNF Receptor (1) Toll-like Receptor (TLR) (5) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (8) Neurological Disease (1)
Oligonucleotides:	CpG ODNs (1) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

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Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149652

IRF5-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology
IRF5-IN-1 (Compound C5) is a conformationally locked inhibitor for SLC15A4. IRF5-IN-1 blocks the downstream *IRF5* activation, inhibits the TLR7/8 signaling pathway. IRF5-IN-1 exhibits anti-inflammatory responses .

HY-146244

Agatolimod 1 Publications Verification ODN 2006; PF-3512676; CpG 7909; ODN 7909	Toll-like Receptor (TLR) Bacterial NO Synthase Apoptosis	Infection Cancer
Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC₅₀ of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6, and mediates downstream signaling pathways via IRAK4, IRF5, IRF7. Agatolimod induces Th1-type innate and adaptive immune responses, activates various immune cells and promotes antigen presentation, regulates antibody levels and immune cell infiltration, upregulates the secretion of multiple cytokines, induces apoptosis and cell cycle arrest, enhances cytotoxicity, and clears intracellular Salmonella. Agatolimod is applicable to research on COVID-19, breast cancer, lung adenocarcinoma, HPV-related tumors, melanoma, and salmonellosis ^[5].

HY-150095

YE6144 2 Publications Verification	IFNAR	Inflammation/Immunology
YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .

HY-175759

EN1033	Molecular Glues IFNAR	Inflammation/Immunology
EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders .

HY-P11072

IRF5-CPP5	Toll-like Receptor (TLR) Interleukin Related TNF Receptor	Inflammation/Immunology
IRF5-CPP5 is a cytosolic peptide that selectively targeting human *IRF5* wirh a K_d of 0.53 μM. IRF5-CPP5 disrupts IRF5 homodimerization and inhibits its nuclear translocation without altering IRF5 phosphorylation levels. IRF5-CPP5 inhibits proinflammatory cytokine (IL-6, IL-1β, TNF-α) production. IRF5-CPP5 can be used for the research of systemic lupus erythematosus .

HY-P11003

PTD-N5-1	Toll-like Receptor (TLR)	Inflammation/Immunology
PTD-N5-1 (N5-1) is an *IRF5* inhibitory peptide. PTD-N5-1 blocks β-glucan-induced IL-12 production in IFN-γ primed wild-type and Clec2d-difecient bone-marrow-derived dendritic cells (BMDCs). PTD-N5-1 regulates antifungal immunity through suppression of IRF5-mediated IL-12 production .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	STAT COX Lipoxygenase JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

HY-RS06909

IRF5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IRF5 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IRF5 Human Pre-designed siRNA Set A IRF5 Human Pre-designed siRNA Set A

HY-RS23279

Irf5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irf5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irf5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irf5 Rat Pre-designed siRNA Set A Irf5 Rat Pre-designed siRNA Set A

HY-RS16837

Irf5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Irf5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irf5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Irf5 Mouse Pre-designed siRNA Set A Irf5 Mouse Pre-designed siRNA Set A

HY-150095A

YE6144 free base	IFNAR	Inflammation/Immunology
YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .

HY-P991956

ABB071	Transmembrane Glycoprotein Toll-like Receptor (TLR)	Inflammation/Immunology
ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis .

Cat. No.	Product Name	Target	Research Area

HY-P11072

IRF5-CPP5	Toll-like Receptor (TLR) Interleukin Related TNF Receptor	Inflammation/Immunology
IRF5-CPP5 is a cytosolic peptide that selectively targeting human *IRF5* wirh a K_d of 0.53 μM. IRF5-CPP5 disrupts IRF5 homodimerization and inhibits its nuclear translocation without altering IRF5 phosphorylation levels. IRF5-CPP5 inhibits proinflammatory cytokine (IL-6, IL-1β, TNF-α) production. IRF5-CPP5 can be used for the research of systemic lupus erythematosus .

HY-P11003

PTD-N5-1	Toll-like Receptor (TLR)	Inflammation/Immunology
PTD-N5-1 (N5-1) is an *IRF5* inhibitory peptide. PTD-N5-1 blocks β-glucan-induced IL-12 production in IFN-γ primed wild-type and Clec2d-difecient bone-marrow-derived dendritic cells (BMDCs). PTD-N5-1 regulates antifungal immunity through suppression of IRF5-mediated IL-12 production .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991956

ABB071	Transmembrane Glycoprotein Toll-like Receptor (TLR)	Inflammation/Immunology
ABB071 is a humanized anti-CD180 monoclonal antibody. ABB071 can down-regulate the highly expressed TLR7 and IRF5 genes in systemic lupus erythematosus and induce the expression of PNPT1 and DNASE1L3 genes. ABB071 can inhibit the expression of genes related to the type I interferon pathway as well as interferon-stimulated genes (ISGs). ABB071 has anti-inflammatory activity and can reduce the levels of inflammatory cytokines. ABB071 can be used for research on systemic lupus erythematosus and psoriasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	Structural Classification Natural Products Source Classification	STAT COX Lipoxygenase JNK Endogenous Metabolite
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

Species:	Human (2) Mouse (1)
Tag:	SUMO (1) His (3)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70573A

	IRF5 Protein, Human (His) Interferon Regulatory Factor 5; IRF-5; IRF5	Human	E. coli
	The IRF5 protein is a key transcription factor in innate immunity and activates type I interferon (IFN) and inflammatory cytokine genes through endolysosomal Toll-like receptors (TLR7, TLR8, TLR9). It regulates IFN genes and IFN-stimulated genes (ISGs) by binding to ISREs in their promoters. IRF5 Protein, Human (His) is the recombinant human-derived IRF5 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P70573

	IRF5 Protein, Human (His, solution) Interferon Regulatory Factor 5; IRF-5; IRF5	Human	E. coli
	The IRF5 protein is a key transcription factor in innate immunity and activates type I interferon (IFN) and inflammatory cytokine genes through endolysosomal Toll-like receptors (TLR7, TLR8, TLR9). It regulates IFN genes and IFN-stimulated genes (ISGs) by binding to ISREs in their promoters. IRF5 Protein, Human (His, solution) is the recombinant human-derived IRF5 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702592

	IRF5 Protein, Mouse (His-SUMO) IRF5Interferon regulatory factor 5; IRF-5	Mouse	E. coli
	IRF5 Protein, Mouse (His-SUMO) is the recombinant mouse-derived IRF5, expressed by E. coli , with N-6*His, N-SUMO labeled tag. ,

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Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82139

	IRF5 Antibody (YA1884) Interferon regulatory factor 5; Interferon regulatory factor 5 bone marrow variant; IRF 5; SLEB10	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IRF5 Antibody (YA1884) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF5.

HY-P82139A

	IRF5 Antibody (YA1884)(PBS only) Interferon regulatory factor 5; Interferon regulatory factor 5 bone marrow variant; IRF 5; SLEB10	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	IRF5 Antibody (YA1884) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRF5.