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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Irf5
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Irf5" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: ODN 2006; PF-3512676; CpG 7909; ODN 7909
Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC50 of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6, and mediates downstream signaling pathways via IRAK4, IRF5, IRF7. Agatolimod induces Th1-type innate and adaptive immune responses, activates various immune cells and promotes antigen presentation, regulates antibody levels and immune cell infiltration, upregulates the secretion of multiple cytokines, induces apoptosis and cell cycle arrest, enhances cytotoxicity, and clears intracellular Salmonella. Agatolimod is applicable to research on COVID-19, breast cancer, lung adenocarcinoma, HPV-related tumors, melanoma, and salmonellosis [5].
2
2 Cited Publications
Target:
Research Areas:
IRF5-IN-1 (Compound C5) is a conformationally locked inhibitor for SLC15A4. IRF5-IN-1 blocks the downstream IRF5 activation, inhibits the TLR7/8 signaling pathway. IRF5-IN-1 exhibits anti-inflammatory responses .
2
2 Cited Publications
Target:
Research Areas:
YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .
1
1 Cited Publications
Cat. No.: HY-P70573A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Irf5; Interferon Regulatory Factor 5 Transcript Variant 15; Interferon Regulatory Factor 5; Interferon Regulatory Factor 5 Transcript Variant 17; Irf-5; Interferon Regulatory Factor 5 Variant 7; Interferon Regulatory Factor 5 Transcript Variant 16; Interf
Species:
Human
Source:
E. coli
Cat. No.: HY-175759
CAS No.: 2193367-28-9
Target:
Research Areas:
EN1033 is a covalent immune regulatory transcription factor 5/8 (IRF5/8) molecular glue degrader. EN1033 degrades IRF5 in a proteasome-dependent manner. EN1033 engages and degrades IRF8 more robustly and rapidly. EN1033 covalently targets C28 and C223 to destabilize and degrade IRF5 and IRF8 respectively, thereby inhibiting their pro-inflammatory transcriptional activity. EN1033 serves as a promising tool for the study of autoimmune and inflammatory disorders .
Cat. No.: HY-P11072
CAS No.: 1601299-92-6
Research Areas:
Cat. No.: HY-RS06909
Target:
Research Areas:
IRF5 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23279
Target:
Research Areas:
Irf5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irf5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P11003
CAS No.: 2088834-68-6
Target:
Research Areas:
PTD-N5-1 is an IRF5 inhibitory peptide. PTD-N5-1 blocks the activation of IRF5. PTD-N5-1 inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 is applicable to the research of Candida albicans infection .
Cat. No.: HY-186312
Research Areas:
PROTAC IRF5 degrader-2 (I-7) is a bifunctional IRF5 PROTAC degrader. PROTAC IRF5 degrader-2 recruits IRF5 to the E3 ubiquitin ligase for targeted degradation. PROTAC IRF5 degrader-2 is applicable to the research of autoimmune diseases .
Cat. No.: HY-186304
Target:
Research Areas:
PROTAC IRF5 degrader-1 (I-867) is a CRBN-recruiting PROTAC degrader targeting IRF5. PROTAC IRF5 degrader-1 recruits interferon regulatory factor 5 (IRF5) protein to the E3 ubiquitin ligase for degradation. PROTAC IRF5 degrader-1 can be used in the research of autoimmune diseases .
Cat. No.: HY-188209
CAS No.: 3137885-65-2
Research Areas:
PROTAC IRF5 degrader-3 is a PROTAC degrader targeting interferon regulatory factor 5 (IRF5), with a DC50 of 1-10 nM. PROTAC IRF5 degrader-3 can be used in research on IRF5-associated autoimmune and inflammatory diseases, such as systemic lupus erythematosus and rheumatoid arthritis .
Cat. No.: HY-RS16837
Target:
Research Areas:
Irf5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irf5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702592
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Irf5; Interferon Regulatory Factor 5 Transcript Variant 15; Interferon Regulatory Factor 5; Interferon Regulatory Factor 5 Transcript Variant 17; Irf-5; Interferon Regulatory Factor 5 Variant 7; Interferon Regulatory Factor 5 Transcript Variant 16; Interf
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P11003A
Target:
Research Areas:
PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate blocks the activation of IRF5. PTD-N5-1 acetate inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 acetate reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 acetate is applicable to the research of Candida albicans infection .
Cat. No.: HY-150095A
CAS No.: 3065657-01-1
Target:
Research Areas:
YE6144 free base is a selective prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 free base suppresses the disease course and is especially effective in remission maintenance in a mouse model of systemic lupus erythematosus (SLE). YE6144 free base can be used for SLE research .
Cat. No.: HY-P991956
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
