Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
163 Results for "
Kinetics
" in MedChemExpress (MCE) Product Catalog:
Products (163)
163 Results for "Kinetics" in MCE Product Catalog:
32
32 Cited Publications
FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios .
22
22 Cited Publications
Cat. No.: HY-W099571
CAS No.: 4485-12-5
Synonyms: Stearic acid lithium; Lithium octadecanoate
Research Areas:
Lithium stearate (Stearic acid (lithium)) is a compound that forms vesicles in reaction with silver nitrate, thereby changing the reaction kinetics of the nucleation and self-assembly process of silver stearate. It has the activity that even in the presence of excess silver nitrate, only about 80% can be converted into silver stearate and the residual lithium stearate will inhibit the growth process of silver stearate crystals, thereby producing silver stearate crystals that are much smaller than those obtained from sodium stearate, providing an opportunity to further control the self-assembly and crystal growth of silver stearate.
8
8 Cited Publications
Synonyms: nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride
Target:
Research Areas:
Norbinaltorphimine dihydrochloride (nor-Binaltorphimine dihydrochloride; nor-BNI dihydrochloride) is a selective, long-acting competitive antagonist of the κ-opioid receptor. Norbinaltorphimine dihydrochloride blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. Norbinaltorphimine dihydrochloride suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. Norbinaltorphimine dihydrochloride is applicable to research related to neurological disorders such as pain .
8
8 Cited Publications
Synonyms: Norbinaltorphimine; NorBNI
Target:
Research Areas:
nor-Binaltorphimine (Norbinaltorphimine; NorBNI) is a selective, long-acting competitive antagonist of the κ-opioid receptor. nor-Binaltorphimine blocks κ-opioid receptor-mediated analgesic effects, and inhibits butorphanol-induced changes in κ-opioid receptor binding kinetics, desensitization and down-regulation. nor-Binaltorphimine suppresses specific opioid withdrawal symptoms, precipitates withdrawal behaviors in butorphanol-dependent rats, and serves as a molecular probe for studying κ-opioid receptor-agonist interactions. nor-Binaltorphimine is applicable to research related to neurological disorders such as pain .
6
Target:
Research Areas:
NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively . NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM) .
3
3 Cited Publications
Cat. No.: HY-W015239
CAS No.: 605-62-9
Target:
Research Areas:
KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases .
2
2
2 Cited Publications
Synonyms: GDP disodium salt
1
1 Cited Publications
Target:
Research Areas:
Cy5.5 DBCO is a click chemistry reagent containing an cycloalkynes group. Cy5.5 DBCO is a linker of Cyanine5.5 fluorophore. DBCO group enables copper free biocompatible click chemistry with fast reaction kinetics and good stability .
1
Tryptophanase is a zymogen-converting enzyme and inducible enzyme that can convert its inactive precursor form into an active enzyme without additional polypeptide synthesis. In Escherichia coli K12, tryptophanase functions as an inducible enzyme, and its induction kinetics are similar to those of β-galactosidase. Tryptophanase catalyzes the conversion of L-tryptophan to indole .
1
1 Cited Publications
Cat. No.: HY-117374
CAS No.: 2044701-99-5
HDAC3-IN-1 (compound 5) is a potent and selective HDAC3 inhibitor, with an IC50 of 5.96 nM .
1
Target:
Research Areas:
Icapamespib (PU-HZ151; PU-AD) is a selective, orally active inhibitor of Epichaperomes assembled by HSP90 with slow dissociation kinetics. Icapamespib can cross the blood-brain barrier (BBB) ??and induce epichaperome disassembly by non-covalently binding to HSP90, restoring the normal protein-protein interaction network. Icapamespib can specifically disrupt disease-related abnormal protein interaction networks, reduce neurotoxic protein aggregation and tumor cell survival signals. Icapamespib can be used in the research of neurodegenerative diseases such as Alzheimer's disease, as well as cancers such as glioblastoma and metastatic breast cancer .
1
1 Cited Publications
Synonyms: PU-HZ151 hydrochloride
Target:
Research Areas:
Icapamespib (PU-HZ151; PU-AD) hydrochloride is a selective, orally active inhibitor of Epichaperomes assembled by HSP90 with slow dissociation kinetics. Icapamespib hydrochloride can cross the blood-brain barrier (BBB) ??and induce epichaperome disassembly by non-covalently binding to HSP90, restoring the normal protein-protein interaction network. Icapamespib hydrochloride can specifically disrupt disease-related abnormal protein interaction networks, reduce neurotoxic protein aggregation and tumor cell survival signals. Icapamespib hydrochloride can be used in the research of neurodegenerative diseases such as Alzheimer's disease, as well as cancers such as glioblastoma and metastatic breast cancer .
1
Research Areas:
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (thyroid hormone receptor) inhibitor, with IC50 values of 4.5 and 5.1 μM, respectively. KB130015 markedly slows the kinetics of inactivation of Na + channels. KB130015 activates hERG1 channels (EC50 = 12.2 μM) and large-conductance Ca 2+-activated K + (BKCa) channels formed by hSlo1 (α) subunits in HEK 293 cells. KB130015 has antiarrhythmic properties. KB130015 can be used for the study of cardiovascular disease .
Cat. No.: HY-N1495
CAS No.: 34620-76-3
Synonyms: Maltopentose
Category:
Hordeum vulgare L. Plants Endogenous metabolite Human Gut Microbiota Metabolites Polysaccharides Microorganisms Gramineae Disease Research Fields Inflammation/Immunology Saccharides
Target:
Synonyms: 4-Nitrophenyl a-D-mannopyranoside
Cat. No.: HY-E70336
CAS No.: 93792-13-3
Target:
Research Areas:
Peroxidase, Lignin is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
Synonyms: D-Trans-Allethrin; Esbiol
Research Areas:
S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils .
Target:
Research Areas:
4-Methylumbelliferyl β-D-cellobioside is a substrate of Cellulase (HY-B2220). 4-Methylumbelliferyl β-D-cellobioside can be hydrolyzed and produces fluorescent 4-methylumbelliferone, which can be used to study the kinetics of cellulases .
Cat. No.: HY-138126
CAS No.: 113527-49-4
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
