MUC5AC

Isoforms Recommended:	MUC5AC

By Targets:	Amino Acid Derivatives (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) Bacterial (2) CCR (2) COX (2) Dopamine Receptor (3) Drug Derivative (1) EGFR (1) Glycosidase (1) IKK (1) Interleukin Related (2) mAChR (1) MMP (1) Mucin (4) NF-κB (8) NO Synthase (1) Notch (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (8) Endocrinology (2) Infection (3) Inflammation/Immunology (8)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	COX CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits *MUC5AC* gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-100958

4-DAMP 4 Publications Verification 4-DAMP methiodide	mAChR Apoptosis MMP EGFR Interleukin Related	Inflammation/Immunology Cancer
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .

HY-B0393

Fudosteine 1 Publications Verification	Amino Acid Derivatives	Inflammation/Immunology
Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .

HY-NP159

House Dust Mite Extract, from D.farinae	Mucin Interleukin Related	Inflammation/Immunology
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, *IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC*. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

HY-N2098

Obtusifolin 4 Publications Verification	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-P0280

MUC5AC motif peptide	Mucin	Inflammation/Immunology Cancer
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.

HY-103431

A68930 hydrochloride 1 Publications Verification	Dopamine Receptor	Others
A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .

HY-N1510

Kaempferol 3-O-gentiobioside	Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)	Infection Inflammation/Immunology Cancer
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a K_a value of 57 µM against human NOTCH1 and an IC₅₀ value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of *MUC5AC, reduces nitrite and ROS* levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the *TGF-β/ALK5/Smad* signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Mucin	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of *MUC5AC*. Ensituximab shows specificity to colorectal and pancreatic cancer .

HY-RS17212

Muc5ac Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Muc5ac Mouse Pre-designed siRNA Set A contains three designed siRNAs for Muc5ac gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Muc5ac Mouse Pre-designed siRNA Set A Muc5ac Mouse Pre-designed siRNA Set A

HY-RS08844

MUC5AC Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MUC5AC Human Pre-designed siRNA Set A MUC5AC Human Pre-designed siRNA Set A

HY-RS23664

Muc5ac Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Muc5ac Rat Pre-designed siRNA Set A contains three designed siRNAs for Muc5ac gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Muc5ac Rat Pre-designed siRNA Set A Muc5ac Rat Pre-designed siRNA Set A

HY-117616

Laurotetanine (+)-Laurotetanine	NF-κB	Cancer
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating *MUC5AC* and NF-κB signaling pathways .

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	COX Reference Standards CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-N2098R

Obtusifolin (Standard)	Reference Standards NF-κB	Cancer
Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-126232

Verproside	NF-κB TNF Receptor IKK	Infection Inflammation/Immunology
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-120687

A68930	Dopamine Receptor	Cancer
A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .

HY-N18053

Anabsinthin	Drug Derivative Bacterial NF-κB NO Synthase	Infection
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and *MUC5AC* protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker .

HY-103431R

A68930 hydrochloride (Standard)	Reference Standards Dopamine Receptor	Others
A68930 hydrochloride (Standard) is the analytical standard of A68930 hydrochloride (HY-103431). This product is intended for research and analytical applications. A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis .

Cat. No.	Product Name	Type

HY-NP159

House Dust Mite Extract, from D.farinae	Biochemical Assay Reagents
House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, *IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC*. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

House Dust Mite Extract, from D.farinae

Biochemical Assay Reagents

House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .

Cat. No.	Product Name	Target	Research Area

HY-P0280

MUC5AC motif peptide	Mucin	Inflammation/Immunology Cancer
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.

HY-P5508

MUC5AC-13	Peptides	Others
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC* gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)

HY-P5512

MUC5AC-3	Peptides	Others
MUC5AC-3 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

HY-P5511

MUC5AC-3/13	Peptides	Others
MUC5AC-3/13 is a biological active peptide. (glycopeptide transferase, ppGaNTase-T9 substrate)

Cat. No.	Product Name	Target	Research Area	Image

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Mucin	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of *MUC5AC*. Ensituximab shows specificity to colorectal and pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2609

7,4'-Dihydroxyflavone 4 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Endocrinology Source Classification	COX CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits *MUC5AC* gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

HY-N2098

Obtusifolin 4 Publications Verification	Seeds of Cassia tora Linn. Quinones other families Classification of Application Fields Leguminosae Anthraquinones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	NF-κB
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-N1510

Kaempferol 3-O-gentiobioside	Flavonols Structural Classification Flavonoids Sauropus spatulifolius Beille Classification of Application Fields Phenols Polyphenols Metabolic Disease Euphorbiaceae Plants Disease Research Fields Source Classification	Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK)
Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a K_a value of 57 µM against human NOTCH1 and an IC₅₀ value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of *MUC5AC, reduces nitrite and ROS* levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the *TGF-β/ALK5/Smad* signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .

HY-117616

Laurotetanine (+)-Laurotetanine	Alkaloids Aporphine Alkaloids Classification of Application Fields Plants Lauraceae Isoquinoline Alkaloids Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer Source Classification	NF-κB
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating *MUC5AC* and NF-κB signaling pathways .

HY-N2609R

7,4'-Dihydroxyflavone (Standard)	Structural Classification Flavonoids Flavones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	COX Reference Standards CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .

HY-N2098R

Obtusifolin (Standard)	Seeds of Cassia tora Linn. Quinones Structural Classification other families Leguminosae Anthraquinones Phenols Polyphenols Plants Source Classification	Reference Standards NF-κB
Obtusifolin (Standard) is the analytical standard of Obtusifolin. This product is intended for research and analytical applications. Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .

HY-126232

Verproside	Plantaginaceae Infection Iridoids Veronica officinalis L. Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification	NF-κB TNF Receptor IKK
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD) .

HY-N18053

Anabsinthin	Triterpenes Structural Classification Terpenoids Plants Acacia confusa Merr. Compositae Source Classification	Drug Derivative Bacterial NF-κB NO Synthase
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and *MUC5AC* protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (1) Mouse (2)
Application:	IHC-P (3) ICC/IF (3) IP (1) WB (2) ELISA (2)
Isotype:	IgG (1) IgG1 (1) IgG/Kappa (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85981

	Mucin 5AC Antibody (YA5673) MUCin-5AC; Gastric MUCin; Major airway glycoprotein; MUCin-5 subtype AC, tracheobronchial; Tracheobronchial MUCin; MUC5; MUC5AC	IHC-P, ICC/IF, ELISA	Human, Mouse
	Mucin 5AC Antibody (YA5673) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Mucin 5AC.

HY-P86572

	Mucin 5AC Antibody (YA6264) MUCin-5AC; Gastric MUCin; Major airway glycoprotein; MUCin-5 subtype AC, tracheobronchial; Tracheobronchial MUCin; MUC5; MUC5AC	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Mucin 5AC Antibody (YA6264) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucin 5AC.

HY-P80988

	Mucin 5AC Antibody (YA3524) ApoMUCin; Gastric MUCin; LeB; MUC5AC; MUCin 5AC oligomeric MUCus/gel forming; TBM	WB, IHC-P, ICC/IF	Human
	Mucin 5AC Antibody (YA3524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mucin 5AC.

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Cat. No.	Product Name		Classification

HY-RS17212

Muc5ac Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Muc5ac Mouse Pre-designed siRNA Set A contains three designed siRNAs for Muc5ac gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08844

MUC5AC Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MUC5AC Human Pre-designed siRNA Set A contains three designed siRNAs for MUC5AC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23664

Muc5ac Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Muc5ac Rat Pre-designed siRNA Set A contains three designed siRNAs for Muc5ac gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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MUC5AC

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