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Results for "

Microtubule/Tubulin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (220) ADC Antibody (1) ADC Linker (1) ADC Payload (29) Akt (1) Amino acid Transporter (1) Amyloid-β (2) Anion Exchangers (1) Antibiotic (6) Apoptosis (103) Atg8/LC3 (1) Autophagy (11) Bacterial (6) Bcl-2 Family (8) Bcr-Abl (2) Biochemical Assay Reagents (1) Caspase (13) CDK (2) Cholinesterase (ChE) (3) Cytochrome P450 (2) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (3) Drug Isomer (1) EGFR (2) Endogenous Metabolite (3) Environmental Pollutants (2) ERK (1) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (2) FGFR (1) Fluorescent Dye (2) Fungal (6) Herbicide (3) HIF/HIF Prolyl-Hydroxylase (5) Hippo (MST) (1) Histone Demethylase (1) HIV (1) IRE1 (1) Isotope-Labeled Compounds (12) JAK (1) JNK (3) Kinesin (5) MDM-2/p53 (2) Mitochondrial Metabolism (2) Mitosis (18) NOD-like Receptor (NLR) (5) P-glycoprotein (3) p62 (1) Parasite (8) PARP (4) PERK (1) Phosphatase (1) Polo-like Kinase (PLK) (1) Prolyl Endopeptidase (PREP) (1) Ras (1) Reactive Oxygen Species (ROS) (7) Reference Standards (21) STAT (2) TNF Receptor (1) VEGFR (1) Wee1 (1) Wnt (3) YAP (1)
By Research Areas:	Cancer (223) Cardiovascular Disease (2) Endocrinology (2) Infection (16) Inflammation/Immunology (11) Metabolic Disease (2) Neurological Disease (14)
Click Chemistry:	Azide (1) Alkynes (1)

251

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

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Isotope-Labeled Compounds

Click Chemistry

GMP Molecules

Targets Recommended: Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST) MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13520

Nocodazole Maximum Cited Publications 119 Publications Verification Oncodazole; R17934	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of *microtubule. Nocodazole binds to β-tubulin* and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-16569

Colchicine 60+ Cited Publications	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)	Cancer
Colchicine, an orally active alkaloid, is a potent *tubulin* inhibitor and a *microtubule* disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N0282

Demecolcine 5+ Cited Publications	Microtubule/Tubulin Apoptosis	Inflammation/Immunology Cancer
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Microtubule/Tubulin	Cancer
Combretastatin A4 is a *microtubule*-targeting agent that binds *β-tubulin* with K_d of 0.4 μM.

HY-17029

Epothilone B 5+ Cited Publications EPO 906; Patupilone	Microtubule/Tubulin Fungal Apoptosis Antibiotic Bacterial	Infection Cancer
Epothilone B is a microtubule stabilizer (MSA) with a K_i of 0.71μM, and is a MSA with blood-brain barrier permeability. Epothilone B acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation .

HY-10222

Ixabepilone 5+ Cited Publications BMS-247550; Aza-epothilone B	Microtubule/Tubulin Apoptosis Bacterial	Cancer
Ixabepilone (BMS-247550) is an orally bioavailable *microtubule* inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and induces tumor cell apoptosis.

HY-B0294

Flubendazole 5+ Cited Publications	Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy	Infection Cancer
Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .

HY-B0413

Fenbendazole 5+ Cited Publications	Parasite HIF/HIF Prolyl-Hydroxylase Microtubule/Tubulin Antibiotic	Infection Cancer
Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .

HY-13627

Estramustine phosphate sodium 1 Publications Verification	Apoptosis Microtubule/Tubulin Mitosis	Inflammation/Immunology Endocrinology Cancer
Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to *tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis*, which can be used for the research of cancer like prostate cancer .

HY-115364

Parbendazole 5+ Cited Publications SKF 29044	Microtubule/Tubulin Parasite	Infection
Parbendazole is a potent inhibitor of *microtubule* assembly, destabilizes tubulin, with an EC₅₀ of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Microtubule/Tubulin ADC Payload	Cancer
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-121993

Combretastatin A-1 1 Publications Verification	Wnt Microtubule/Tubulin	Cancer
Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects .

HY-100504

S-methyl DM1	Microtubule/Tubulin ADC Payload	Cancer
S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to *tubulin* with a K_d of 0.93 μM and inhibts *microtubule* polymerization. S-methyl DM1 potently suppresses *microtubule* dynamic instability and has anticancer effects .

HY-B0413R

Fenbendazole (Standard)	Reference Standards Parasite HIF/HIF Prolyl-Hydroxylase Microtubule/Tubulin Antibiotic	Infection
Fenbendazole (Standard) is the analytical standard of Fenbendazole. This product is intended for research and analytical applications. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .

HY-16569R

Colchicine (Standard)	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-16191

ELR510444 1 Publications Verification	Microtubule/Tubulin Apoptosis HIF/HIF Prolyl-Hydroxylase Mitosis	Cancer
ELR510444 is an orally active *tubulin* inhibitor with an IC₅₀ of 10 μM. ELR510444 binds to the colchicine-binding site on β-tubulin, inhibits tubulin assembly, depolymerizes microtubules and blocks HIF activity. ELR510444 induces cellular microtubule loss, abnormal mitotic spindle, mitotic arrest, apoptosis, morphological changes in tumor endothelial cells, and inhibits cancer cell proliferation, angiogenesis and tumor growth. ELR510444 can be used in research related to various cancers such as renal cell carcinoma .

HY-41047

Taltobulin intermediate-1	Apoptosis	Cancer
Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis .

HY-41054

Taltobulin intermediate-3	Apoptosis	Cancer
Taltobulin intermediate-3 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis .

HY-41045

(Rac)-Taltobulin intermediate-1	Apoptosis	Cancer
(Rac)-Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis .

HY-78883

ON 01500	Microtubule/Tubulin	Cancer
ON 01500 is a *tubulin* inhibitor with a K_d of 21 nM. ON 01500 exerts microtubule-destabilizing effects in cells. ON 01500 can be used the study of cancers .

HY-176540

Microtubule stabilizer-1	Microtubule/Tubulin	Neurological Disease
Microtubule stabilizer-1 (compound 69) is a brain-penetrant microtubule (MT) stabilizer. Microtubule stabilizer-1 increases acetylated α-tubulin (AcTub) levels and prevents the characteristic loss of neuronal MTs that is observed after incubation with Okadaic acid (HY-N6785). Microtubule stabilizer-1 can be used for the study of Alzheimer’s disease (AD) and related neurodegenerative tauopathies .

HY-B0294R

Flubendazole (Standard)	Reference Standards Parasite Microtubule/Tubulin STAT MDM-2/p53 Apoptosis Autophagy	Infection Cancer
Flubendazole (Standard) is the analytical standard of Flubendazole. This product is intended for research and analytical applications. Flubendazole is an anthelmintic drug based on altering microtubule structure, inhibition of tubulin polymerization and disruption of microtubule function. Flubendazole induces apoptosis in human colorectal cancer (CRC) by blocking the STAT3 signaling axis and activation of autophagy. Flubendazole induces P53 expression and reduced Cyclin B1 and p-cdc2 expression. Flubendazole is an antitumor agent. Flubendazole can be used for worm and intestinal parasites .

HY-156423

Tubulin/JAK2-IN-1	Microtubule/Tubulin JAK	Cancer
Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and *microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative* activity against the cancer cells .

HY-120921

Zoxamide RH-7281	Fungal Microtubule/Tubulin	Infection
Zoxamide (RH-7281) is an oomycete Fungicide and covalent *β-tubulin* inhibitor. RH-7281 inhibits the assembly of tubulin into microtubules in vitro. Zoxamide binds covalently to β-tubulin, disrupting microtubule assembly and the cytoskeleton. Zoxamide blocks nuclear division in germinated hyphae of Phytophthora capsici and inhibits hyphal growth of Phytophthora capsici .

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-145820

Tubulin inhibitor 14	Apoptosis Microtubule/Tubulin	Cancer
Tubulin inhibitor 14 is a potent NQO2 (quinone oxidoreductase 2) inhibitor with an IC₅₀ of 1.0 μM. Tubulin inhibitor 14 also inhibits tubulin polymerization and the formation of endothelial cell capillary-like tubes. Tubulin inhibitor 14 is a microtubule-destabilizing agent with potential tumor-selectivity and antiangiogenic and vascular disrupting features .

HY-157165

Tubulin/PARP-IN-1	Microtubule/Tubulin PARP	Cancer
Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. *Tubulin/PARP*-IN-1 inhibits PARP and tubulin with IC₅₀s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase .

HY-16569S

Colchicine-d6	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-16569S1

Colchicine-d3	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-175555

Tubulin-IN-54	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-54 is a *tubulin* inhibitor. Tubulin-IN-54 exhibits anti-proliferative activity against various cancer cells. Tubulin-IN-54 inhibits *tubulin* polymerization, disrupts microtubule networks, induces G2/M cell cycle arrest, and promotes cancer cell apoptosis. Tubulin-IN-54 demonstrates significant anti-tumor efficacy in mice bearing PC-3/TxR xenografts. Tubulin-IN-54 can be used for the study of taxane-resistant cancers (prostate cancer, melanoma) .

HY-13520R

Nocodazole (Standard) Oncodazole (Standard); R17934 (Standard)	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis Reference Standards	Cancer
Nocodazole (Standard) is the analytical standard of Nocodazole. This product is intended for research and analytical applications. Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-155647

Microtubule stabilizing agent-1	Microtubule/Tubulin	Cancer
Microtubule stabilizing agent-1 (compound 3l) is a Paclitaxel derivative that efficiently promotes tubulin polymerization. Microtubule stabilizing agent-1 shows antitumor efficacy .

HY-171165

JC168	Microtubule/Tubulin	Cancer
JC168 is a phenyl analog of peloruside and serves as a *microtubule* inhibitor, demonstrating antiproliferative and anticancer activities. JC168 promotes tubulin polymerization, thereby interfering with microtubule dynamics, and can be utilized in research related to microtubule-associated disorders .

HY-146311

Tubulin polymerization-IN-16	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells .

HY-119118

J-30	Microtubule/Tubulin	Cancer
J-30 is an orally active and potent *tubulin* inhibitor (IC₅₀=15-20 nM). J-30 disrupts microtubule polymerization and induces G2/M phase arrest. J-30 is promising for research of solid tumors (e.g., gastric, oral) .

HY-110090

UA62784	Microtubule/Tubulin Kinesin Apoptosis	Cancer
UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer .

HY-122151

MPT0B002	Microtubule/Tubulin Apoptosis	Cancer
MPT0B002 is a potent *microtubule* inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase .

HY-16146

Combretastatin A-1 phosphate tetrasodium OXi-4503 tetrasodium	Wnt Microtubule/Tubulin	Cancer
Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a proagent of Combretastatin A-1, is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 phosphate tetrasodium inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 phosphate tetrasodium exhibits anti-tumor and anti-vascular effects .

HY-121993R

Combretastatin A-1 (Standard)	Wnt Microtubule/Tubulin Reference Standards	Cancer
Combretastatin A-1 (Standard) is the analytical standard of Combretastatin A-1. This product is intended for research and analytical applications. Combretastatin A-1 is a microtubule polymerization inhibitor that binds to the colchicine-binding site of tubulin. Combretastatin A-1 inhibits the Wnt/β-catenin pathway through tubulin depolymerization mediated AKT deactivation. Combretastatin A-1 exhibits anti-tumor and anti-vascular effects .

HY-105409

Discodermolide NVP-XAA-296; XAA 296	Microtubule/Tubulin Apoptosis	Cancer
Discodermolide (NVP-XAA-296) is a potent *microtubule*-stabilizing agent with a K_i of 0.4 μM. Discodermolide stabilizes microtubules, induces G2 or M phase cell cycle arrest and apoptosis, leading to inhibition of cancer cell proliferation. Discodermolide competitively inhibits the binding of Paclitaxel (HY-B0015) to tubulin polymers, and inhibits the growth of Paclitaxel-resistant cells. Discodermolide can be used for breast and colon cancer research .

HY-145827

KIF18A-IN-4	Kinesin Microtubule/Tubulin	Cancer
KIF18A-IN-4 is a moderately potent ATP and *microtubule* (MT) noncompetitive KIF18A inhibitor (IC₅₀=6.16 μM). KIF18A-IN-4 has selectivity against a large panel of mitotic kinesins and kinases, and does not show any direct effects on tubulin assembly. KIF18A-IN-4 exhibits anti-tumor activity .

HY-116915

Synstab A	Microtubule/Tubulin Mitosis	Cancer
Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells .

HY-148193

Tubulin polymerization-IN-38	ADC Payload Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs .

HY-137866

Tubulin inhibitor 9	Microtubule/Tubulin	Cancer
Tubulin inhibitor 9 (compound 7) is a tubulin (Microtubule/Tubulin)Inhibitors with anticancer activity (MDA-MB 231, IC₅₀=0.9 nM) .

HY-130960

Tubulysin IM-3	ADC Payload Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130959

Tubulysin IM-2	ADC Payload Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-130958

Tubulysin IM-1	ADC Payload Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis .

HY-161145

EGFR/microtubule-IN-1	EGFR Apoptosis Microtubule/Tubulin	Cancer
EGFR/microtubule-IN-1 (Compound 10c) is a dual inhibitor targeting EGFR and tubulin. The IC₅₀ for inhibiting EGFR is 10.66 nM. EGFR/microtubule-IN-1 can reduce the phosphorylation levels of EGFR, AKT and ERK, hinder tubulin polymerization, and induce apoptosis .

HY-176201

Tubulin polymerization-IN-80	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-80 (Compound 32) is a potent tubulin polymerization inhibitor with antiproliferative activity. Tubulin polymerization-IN-80 disrupts microtubule formation and leads to cell cycle arrest and apoptosis. Tubulin polymerization-IN-80 is promising for research of cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16569

Colchicine 60+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)
Colchicine, an orally active alkaloid, is a potent *tubulin* inhibitor and a *microtubule* disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N0488

Vincristine sulfate Maximum Cited Publications 74 Publications Verification Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Anti-aging Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Apoptosis Microtubule/Tubulin Mitosis
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to *β-tubulin* (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0282

Demecolcine 5+ Cited Publications	Alkaloids other families Classification of Application Fields Other Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N0488A

Vincristine Maximum Cited Publications 74 Publications Verification Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification Cancer	Apoptosis Microtubule/Tubulin Mitosis
Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to *β-tubulin* (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Combretastatin A4 is a *microtubule*-targeting agent that binds *β-tubulin* with K_d of 0.4 μM.

HY-20584

10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Cancer Source Classification Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin ADC Payload
10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.

HY-N7053

Tubulysin M	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification Cancer	ADC Payload Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N1408

trans-Trimethoxyresveratrol trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene	other families Stilbenes Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	VEGFR Reactive Oxygen Species (ROS) Caspase Apoptosis
Trans-Trimethoxyresveratrol (trans-trismethoxy Resveratrol; (E)-Resveratrol trimethyl ether; trans-3,5,4'-Trimethoxystilbene) is an orally active natural derivative of Resveratrol (HY-16561). Trans-Trimethoxyresveratrol has an enhanced anticancer profile compared to Resveratrol, exhibiting higher potency than resveratrol, with improved cancer cell proliferation inhibition, induction of cell cycle arrest, decreased metastasis, and increased apoptosis. Trans-Trimethoxyresveratrol causes microtubule disassembling and tubulin depolymerization and exerts anti-angiogenic effects through VEGFR2. Trans-Trimethoxyresveratrol can be used for the studies of anti-angiogenic and anti-cancer (such as non-small cell lung cancer and osteosarcoma) .

HY-N1243

Tubulysin B	Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent *microtubule* destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits *tubulin* polymerization and leads to cell cycle arrest and apoptosis .

HY-N2438

Methylophiopogonanone B 2 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Flavonoids Liliaceae Classification of Application Fields Other Diseases Phenols Polyphenols Plants Other Flavonoids Disease Research Fields Source Classification	Ras Microtubule/Tubulin
Methylophiopogonanone B is a homoisoflavonoid compound. Methylophiopogonanone B can be isolated from O. japonicus root. Methylophiopogonanone B promotes Rho activation and Tubulin depolymerization. Methylophiopogonanone B significantly increases GTP-Rho, but not GTP-Rac or GTP-CDC42. Methylophiopogonanone B induces cell morphological change via melanocyte dendrite retraction and stress fiber formation. Methylophiopogonanone B exhibits strong antioxidant activity. Methylophiopogonanone B can be used in the research of cervical cancer .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Source Classification Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of *tubulin* and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Plants Source Classification	Reference Standards Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N2348

Tubulysin D	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification Cancer	ADC Payload Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Natural Products Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Structural Classification Monophenols other families Stilbenes Phenols Plants Source Classification	Reference Standards Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-N7049

Tubulysin F	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2346

Tubulysin E	Natural Products Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Cancer Source Classification	ADC Payload Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-127166

Colchiceine O10-Demethylcolchicine	Colchicaceae Alkaloids Other Alkaloids Plants Colchicum autumnale L. Source Classification	Microtubule/Tubulin
Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a *tubulin* inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N0488R

Vincristine sulfate (Standard) Leurocristine sulfate (Standard); NSC-67574 sulfate (Standard); 22-Oxovincaleukoblastine sulfate (Standard)	Apocynaceae Alkaloids Structural Classification Plants Alkaloid Dimers Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Apoptosis Microtubule/Tubulin Mitosis
Vincristine (sulfate) (Standard) is the analytical standard of Vincristine (sulfate). This product is intended for research and analytical applications. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to *β-tubulin* (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N1098R

Velutin (Standard)	Structural Classification Flavonoids Microorganisms other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards HIF/HIF Prolyl-Hydroxylase
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-127166R

Colchiceine (Standard) O10-Demethylcolchicine (Standard)	Colchicaceae Alkaloids Other Alkaloids Plants Colchicum autumnale L. Source Classification	Microtubule/Tubulin Reference Standards
Colchiceine (Standard) is the analytical standard of Colchiceine. This product is intended for research and analytical applications. Colchiceine is one of several metabolites of the anti-gout medication Colchicine (HY-16569). Colchicine is a tubulin inhibitor and a microtubule disrupting agent, and may protect rats from developing liver injury and fibrosis .

HY-N14734

Disorazol A	Natural Products Microorganisms Source Classification	Apoptosis Fungal Microtubule/Tubulin Mitosis
Disorazol A1 is an *tubulin* inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G₂/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC₅₀ value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers .

HY-N1391R

10-Deacetyltaxol (Standard) 10-Deacetylpaclitaxel (Standard)	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Taxus wallichiana Zucc. Source Classification	Reference Standards Microtubule/Tubulin
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N0060AR

Ferulic acid sodium (Standard) Coniferic acid sodium (Standard)	Structural Classification Monophenols other families Simple Phenylpropanols Phenols Phenylpropanoids Plants Endogenous metabolite Source Classification	Reference Standards FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N16760

Wikstrol B	Structural Classification Flavonoids Flavones Thymelaeaceae Phenols Plants Source Classification Wikstroemia indica	Microtubule/Tubulin HIV
Wikstrol B (compound 5) is a biflavonoid *microtubule/tubulin* inhibitor and HIV-1 inhibitor. Wikstrol B has an IC₅₀ value of 184 μM for microtubule polymerization and an EC₅₀ of 3.02 μM against HIV-1, acting on early events of HIV-1 replication. Wikstrol B exerts antifungal activity by inducing morphological deformation of Pyricularia oryzae hyphae and exerts anti-mitotic activity by inhibiting microtubule polymerization. Wikstrol B can be used in research related to antifungal, antitumor, and anti-AIDS applications. Wikstrol B can be naturally extracted from the roots of Wikstroemia indica .

HY-N12331

Ohchinolide B	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Microtubule/Tubulin
Ohchinolide B is a *tubulin* inhibitor. Ohchinolide B inhibits microtubule polymerization (IC₅₀=2.3 μM) and induces G2/M phase cell cycle arrest via mitochondrial apoptotic pathways. Ohchinolide B is promising for research of solid tumors (e.g., breast, lung cancer) .

HY-N13795

3,4,3'-Tri-O-methylflavellagic acid	Terminalia paniculata Roth Structural Classification Combretaceae Phenols Polyphenols Plants Source Classification	Polo-like Kinase (PLK) Microtubule/Tubulin
3,4,3'-Tri-O-methylflavellagic acid is a flavonoid inhibitor that targets *αβ-tubulin* (colchicine binding site) and polo-like kinase-1 (PLK-1), and can be isolated from the roots of Anogeissus leiocarpus. 3,4,3'-Tri-O-methylflavellagic acid interferes with microtubule assembly dynamics and kinase activity, exhibiting anti-cancer cell proliferation and potent anti-nociceptive effects .

HY-Z9022

Iso cephalomannine	Structural Classification Terpenoids Taxaceae Diterpenoids Plants Source Classification	Microtubule/Tubulin
Iso cephalomannine is a tubulin-targeting cytotoxic agent. Iso cephalomannine induces cytotoxicity in breast cancer cells. Iso cephalomannine can be used in breast cancer-related research .

Cat. No.	Product Name	Chemical Structure

HY-B0413S

Fenbendazole-d3

5 Publications Verification

Fenbendazole-d₃ is a deuterium labeled Fenbendazole. Fenbendazole-d₃ is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53 .

HY-15582S

Auristatin E-d8

Auristatin E-d₈ is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .

HY-N0488S

Vincristine-d3 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM . Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

HY-N0488S2

Vincristine-d6 sulfate

Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-N0488S1

Vincristine-d3-1 sulfate

Vincristine-d₃ sulfate is the deuterium labeled Vincristine sulfate. Vincristine-1 sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine-1 sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine-1 sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine-1 sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .

HY-W754654

Epothilone B-d3 (synthetic)
Epothilone B-d₃ (synthetic) is the deuterium labeled Epothilone B (HY-17029). Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.

HY-115364S

Parbendazole-d3
Parbendazole-d₃ is the deuterium labeled Parbendazole. Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

HY-136610S

Chlorpyrifos-oxon-d10
Chlorpyrifos-oxon-d₁₀ is the deuterium labeled Chlorpyrifos-oxon. Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a potent phosphorylating agent that potently inhibits AChE. Chlorpyrifos-oxon can induce cross-linking between subunits of tubulin and disrupt microtubule function .

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents .

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent *microtubule* inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-125374S

Larotaxel-d9

Larotaxel-d₉ (XRP9881-d₉) is the deuterium labeled Larotaxel (HY-125374). Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

Targets Recommended: Microtubule/Tubulin Microtubule‐associated serine/threonine kinase (MAST) MARK MASTL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-78738G

MC-Val-Cit-PAB	ADC Linker	Cancer
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

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