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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
108 Results for "
NEP
" in MedChemExpress (MCE) Product Catalog:
Products (108)
108 Results for "NEP" in MCE Product Catalog:
7
7 Publications Verification
Art. -Nr.: HY-17620
CAS. Nr.: 149709-44-4
Synonyms: Desethyl Sacubitril; LBQ-657
Target:
Forschungsgebiete:
Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
3
3 Cited Publications
Art. -Nr.: HY-W013375
CAS. Nr.: 76721-89-6
Target:
Forschungsgebiete:
Thiorphan is a selective neprilysin (NEP) inhibitor with an IC50 of 6.9 nM. Thiorphan competitively binds to NEP and blocks its activity, preventing the degradation of neuropeptides such as substance P (SP) and neurokinin NKA. In the field of neonatal brain injury research, Thiorphan can increase the levels of SP and NKA, activate NK1 and NK2 receptors and downstream transduction pathways, and inhibit excessive activation of NMDA receptors. Thus, Thiorphan can protect neocortical neurons from excitotoxic cell death. Thiorphan may also inhibit NEP from enhancing bronchoconstriction and can be used in the study of respiratory diseases .
3
Target:
Forschungsgebiete:
Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 .
3
3 Cited Publications
Synonyms: AHU-377 sodium
Target:
Forschungsgebiete:
Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 .
3
Target:
Forschungsgebiete:
Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent .
3
3 Cited Publications
Synonyms: AHU-377 hemicalcium salt
Target:
Forschungsgebiete:
Sacubitril hemicalcium salt (AHU-377 hemicalcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696.
2
Forschungsgebiete:
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
2
2 Cited Publications
Art. -Nr.: HY-P1242
CAS. Nr.: 475221-20-6
Target:
Forschungsgebiete:
Art. -Nr.: HY-N2021A
CAS. Nr.: 164204-38-0
Synonyms: AHU-377-d4
Art. -Nr.: HY-19649
CAS. Nr.: 123122-55-4
Synonyms: UK 79300
Target:
Forschungsgebiete:
Candoxatril is a neutral endopeptidase (NEP) inhibitor.
Art. -Nr.: HY-174996
CAS. Nr.: 3031840-36-2
Target:
Forschungsgebiete:
NEP162 is a BRD4 PROTAC degrader with DC50s of 1.2 and 1.6 μM in SW480 and U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibits tumor growth and induces apoptosis. NEP162 can be used for the study of osteosarcoma, colorectal cancer and non-small cell lung cancer, etc. (Pink: BRD4 ligand : (HY-78695), Blue: E3 ligase Ligand (HY-D2259), BLACK: Linker, E3 ligase ligand-linker conjugate (HY-174997)) .
Art. -Nr.: HY-RS03621
Forschungsgebiete:
Ddr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS03620
Forschungsgebiete:
DDR1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: UK-81252
Forschungsgebiete:
Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation .
Art. -Nr.: HY-N2021
CAS. Nr.: 36357-77-4
Category:
Art. -Nr.: HY-P5754B
Target:
Forschungsgebiete:
Art. -Nr.: HY-W013375S
CAS. Nr.: 1276297-68-7
Art. -Nr.: HY-U00171
CAS. Nr.: 100845-83-8
Synonyms: SQ28,603; Squibb 28603
Target:
Forschungsgebiete:
SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
