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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
NHC
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "NHC" in MCE Product Catalog:
42
42 Publications Verification
Synonyms: β-D-N4-hydroxycytidine; NHC
Target:
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EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
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11 Cited Publications
Cat. No.: HY-135867E
Purity: 97.09%
Research Areas:
NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetraammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .
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1 Cited Publications
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1 Cited Publications
Cat. No.: HY-135867F
Purity: 98.80%
Cat. No.: HY-135867
CAS No.: 34973-27-8
Cat. No.: HY-135867A
Cat. No.: HY-142956
Purity: 99.65%
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ROS-ERS inducer 1 is a type II ICD (immunogenic cell death) inducer. ROS-ERS inducer 1 is a Pt(II)-N-heterocyclic carbene (Pt(II)-NHC) complex derived from 4,5-diarylimidazole. ROS-ERS inducer 1 successfully induces endoplasmic reticulum stress (ERS) accompanied by reactive oxygen species (ROS) generation and finally lead to the release of damage-associated molecular patterns (DAMPs) in HCC cells. ROS-ERS inducer 1 displays much higher anticancer activities than Cisplatin .
Cat. No.: HY-W010978
CAS No.: 873779-78-3
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IMesCuCl is a neutral (NHC) copper (I) complex. IMesCuCl exhibits cytotoxic activity against cancer cells. IMesCuCl can be used in the research of breast cancer, lung cancer, melanoma and glioma .
Cat. No.: HY-125033S1
CAS No.: 1955549-12-8
Synonyms: β-D-N4-hydroxycytidine-d2; NHC-d2
Cat. No.: HY-117105
CAS No.: 280138-71-8
DAPD-NHc-pr (compound 12) is an HIV inhibitor with EC50/EC90 values of 0.85 μM and 13 μM, respectively. DAPD-NHc-pr shows no toxicity to normal cells (PBM, CEM, VERO) .
Cat. No.: HY-156403
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AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM .
Cat. No.: HY-140508
CAS No.: 1949843-39-3
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m-PEG12-NH-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-179299
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POI ligand-2-NH-C10H20-NH-Boc is a target protein ligand linker conjugate that contains a GPX4 ligand (HY-179294) and a PROTAC linker (HY-W047688), which can recruit E3 ligases. POI ligand-2-NH-C10H20-NH-Boc can be used for synthesis of PROTAC GPX4 degrader-5 (HY-178925) .
Cat. No.: HY-169083
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Bcl-2-IN-22 (compound 1) is a gold(I) NHC complex with anticancer activity. Bcl-2-IN-22 induces apoptosis via the mitochondrial pathway with an IC50 value of 0.014 μM. In addition, Bcl-2-IN-22 targets BCL-2 family members and exhibits pro-apoptosis and resensitization properties in multidrug-resistant leukemia cells that overexpress BCL-2 .
Cat. No.: HY-161773
Research Areas:
HL389-NHC2-PEG3-C2NH inhibits proliferation of cancer cells MDA-MB-231 and MCF-7, with IC50 of 11.39 μM and 9.66 μM. HL389-NHC2-PEG3-C2NH can be utilized as a conjugate of an E3 ligase ligand and a linker, for the synthesis of PROTAC degrader HL435 (HY-161769) .
Cat. No.: HY-175048
CAS No.: 3035433-94-1
Synonyms: Platinum(II)-N-heterocyclic carbene complex 2C
Research Areas:
Pt(II)-NHC Complex 2C (Platinum(II)-N-Heterocyclic Carbene complex 2C) (Compound 2C) is a platinum(II) complex based on N-heterocyclic carbene (NHC). Pt(II)-NHC Complex 2C is an immunogenic cell death (ICD) inducer that can induce endoplasmic reticulum stress (ERS) in liver cancer cells and produce reactive oxygen species (ROS), ultimately leading to the release of damage-associated molecular patterns (DAMP). Pt(II)-NHC Complex 2C blocks the cell cycle at the S phase and significantly induces cell apoptosis. Pt(II)-NHC Complex 2C shows anti-liver cancer potential in mouse models and activates immune cells in liver injury models.
Cat. No.: HY-180924
CAS No.: 3035510-04-1
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(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359) .
Cat. No.: HY-181358
CAS No.: 2977227-58-8
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(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357) .
Cat. No.: HY-RS16469
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HMGN4 Human Pre-designed siRNA Set A contains three designed siRNAs for HMGN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W754608
Synonyms: β-D-N4-Hydroxycytidine-13C,15N2; NHC-13C,15N2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
