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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
NKCC1
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "NKCC1" in MCE Product Catalog:
19
Target:
Research Areas:
Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na +-K +-Cl + cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] .
3
3 Cited Publications
Target:
Research Areas:
Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively [1].
1
1 Cited Publications
Cat. No.: HY-16689
CAS No.: 893990-34-6
Target:
Research Areas:
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca 2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission [1] .
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Research Areas:
CLP257 is a selective K +-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally [1] .
Cat. No.: HY-172318
CAS No.: 2497525-96-7
Target:
Research Areas:
IAMA-6 is a selective NKCC1 inhibitor with neuroprotective effects. IAMA-6 can be used for the study of brain conditions, including drug-resistant epilepsy (e.g. temporal lobe epilepsy (TLE) and Dravet syndrome (DrS)), autism spectrum disorders (ASD) and Down syndrome (DoS) [1].
Cat. No.: HY-17468R
CAS No.: 28395-03-1
Synonyms: Ro 10-6338 (Standard); PF 1593 (Standard)
Target:
Research Areas:
Bumetanide (Standard) is the analytical standard of Bumetanide. This product is intended for research and analytical applications. Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na +-K +-Cl + cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] .
Cat. No.: HY-17468S
CAS No.: 1216739-35-3
Cat. No.: HY-165407
CAS No.: 99453-84-6
Target:
Research Areas:
Neltenexine is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells . Neltenexine reduces Cl -/HCO3 - uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl - excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels . Neltenexine can be used in research related to chronic obstructive pulmonary disease and emphysema [1] .
Cat. No.: HY-107321R
CAS No.: 27589-33-9
Target:
Research Areas:
Azosemide (Standard) is the analytical standard of Azosemide. This product is intended for research and analytical applications. Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively [1].
Cat. No.: HY-17468A
CAS No.: 28434-74-4
Synonyms: Ro 10-6338 sodium; PF 1593 sodium
Target:
Research Areas:
Bumetanide sodium, a highly potent loop diuretic, is a Na +-K +-Cl + cotransporter (NKCC) blocker. Bumetanide sodium is a selective NKCC1 inhibitor, and also inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] .
Cat. No.: HY-B0135AR
CAS No.: 41733-55-5
Target:
Research Areas:
Furosemide (sodium) (Standard) is the analytical standard of Furosemide (sodium). This product is intended for research and analytical applications. Furosemide sodium is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2 [1]. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide sodium acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .
Cat. No.: HY-189133
CAS No.: 2746327-43-3
Research Areas:
ARN24092 is a selective NKCC1 inhibitor. ARN24092 can be used for research on Down syndrome [1].
Cat. No.: HY-165407A
CAS No.: 99461-80-0
Target:
Research Areas:
Neltenexine hydrochloride is a mucolytic agent and an inhibitor of anion hypersecretion. Neltenexine hydrochloride acts on NKCC1, NBC1 and AE2 transporters located on the basolateral membrane of airway epithelial cells . Neltenexine hydrochloride reduces Cl -/HCO3 - uptake by inhibiting NKCC1 and NBC1, activates AE2 to promote Cl - excretion, reduces β2-adrenergic agonist-induced anion hypersecretion without blocking CFTR channels, and maintains appropriate airway fluid levels . Neltenexine hydrochloride can be used in research related to chronic obstructive pulmonary disease and emphysema [1] .
Cat. No.: HY-RS12997
Target:
Research Areas:
SLC12A2 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC12A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-FL17468
CAS No.: 28395-03-1
Synonyms: Ro 10-6338 solution; PF 1593 solution
Target:
Research Areas:
Bumetanide solution is mainly composed of Bumetanide (HY-17468). Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na +-K +-Cl + cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 μM and 4.0 μM for hNKCC1A and hNKCC2A, respectively [1] .
Cat. No.: HY-FLB0135
CAS No.: 54-31-9
Target:
Research Areas:
Cardiovascular Disease Infection Neurological Disease Metabolic Disease Cancer
Furosemide solution is mainly composed of Furosemide (HY-B0135). Furosemide is a potent and orally active inhibitor of Na +/K +/2Cl - (NKCC) cotransporter, NKCC1 and NKCC2 [1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema .
Cat. No.: HY-110143R
CAS No.: 1181081-71-9
Target:
Research Areas:
CLP257 (Standard) is the analytical standard of CLP257 (HY-110143). This product is intended for research and analytical applications. CLP257 is a selective K+-Cl cotransporter KCC2 activator with an EC50 of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally [1] .
Cat. No.: HY-P702022
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SLC12A2; Bumetanide-Sensitive Cotransporter Type 2; Solute Carrier Family 12 Member 2; Na-K-2Cl Cotransporter 1; NKCC1; HNKCC1; BSC2; Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporters), Member 2, Isoform CRA_a; Basolateral Na-K-Cl Symporter
Species:
Human
Source:
HEK293
Cat. No.: HY-P703077
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC12A2; Bumetanide-Sensitive Cotransporter Type 2; Solute Carrier Family 12 Member 2; Na-K-2Cl Cotransporter 1; NKCC1; HNKCC1; BSC2; Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporters), Member 2, Isoform CRA_a; Basolateral Na-K-Cl Symporter
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
