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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
Notch receptor
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "Notch receptor" in MCE Product Catalog:
16
16 Publications Verification
Synonyms: PF-3084014
Target:
Research Areas:
Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .
16
16 Publications Verification
Synonyms: PF-3084014 dihydrobromide; PF-03084014 dihydrobromide
Target:
Research Areas:
Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .
12
Target:
Research Areas:
ISX-9 (Isoxazole 9) is a potent inducer of adult neural stem cell differentiation. ISX-9 activates Ca 2+ influx through both voltage-gated Ca 2+ channels and NMDA receptors and increases neuroD expression. ISX-9 also induces cardiomyogenic differentiation of Notch-activated epicardium-derived cells (NECs) .
3
3 Cited Publications
Target:
Research Areas:
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .
1
1 Cited Publications
Cat. No.: HY-P78009
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch3; Notch 3-Like Protein; Prev. CADASIL; CADASIL1; Notch 3; CARASIL1; CASIL; FPLD1; Neurogenic Locus Notch Homolog Protein 3; IMF2; Notch (Drosophila) Homolog 3; LMNS; Notch Homolog 3 (Drosophila); Notch receptor 3; Notch Homolog 3
Species:
Human
Source:
HEK293
Cat. No.: HY-15211
CAS No.: 623165-93-5
Target:
Research Areas:
MRK 003 is an orally active γ-secretase inhibitor. MRK 003 targets the Notch signaling pathway by blocking the proteolytic cleavage of Notch receptors. MRK 003 inhibits tumor cell proliferation, induces apoptosis, downregulates anti-apoptotic proteins, upregulates phosphorylated Akt, suppresses angiogenesis, and overcomes microenvironment-mediated proliferative protection. MRK 003 can be used in research related to lung cancer, multiple myeloma, non-Hodgkin's lymphoma, pancreatic ductal adenocarcinoma, glioblastoma, and breast cancer .
Cat. No.: HY-15185R
CAS No.: 1290543-63-3
Synonyms: PF-3084014 (Standard)
Target:
Research Areas:
Nirogacestat (Standard) is the analytical standard of Nirogacestat. This product is intended for research and analytical applications. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers .
Cat. No.: HY-103538
CAS No.: 62252-26-0
Target:
Research Areas:
JLK-6 is a rhomboid protease GlpG inhibitor. JLK-6 reduces the production of Amyloid β-peptide by altering the cleavage of β-amyloid precursor protein by γ-secretase, with no effect on the cleavage of Notch receptors. JLK-6 can be used in research related to Alzheimer's disease .
Cat. No.: HY-116603
CAS No.: 180083-49-2
Target:
Research Areas:
SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis .
Cat. No.: HY-P701028
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch4; Notch (Drosophila) Homolog 4; Prev. INT3; Notch Homolog 4; Neurogenic Locus Notch Homolog Protein 4; Notch4 Protein; Notch 4; HNotch4; Notch receptor 4; Notch Homolog 4 (Drosophila)
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P74683
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Notch4; Notch (Drosophila) Homolog 4; Prev. INT3; Notch Homolog 4; Neurogenic Locus Notch Homolog Protein 4; Notch4 Protein; Notch 4; HNotch4; Notch receptor 4; Notch Homolog 4 (Drosophila)
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71167
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch2; Notch (Drosophila) Homolog 2; Notch receptor 2; Notch Homolog 2 (Drosophila); Notch 2; Notch Homolog 2; Neurogenic Locus Notch Homolog Protein 2; Notch2 Protein; HN2; HJCYS; Neurogenic Locus Notch-Like Protein 2; AGS2
Species:
Human
Source:
HEK293
Cat. No.: HY-P76519
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch2; Notch (Drosophila) Homolog 2; Notch receptor 2; Notch Homolog 2 (Drosophila); Notch 2; Notch Homolog 2; Neurogenic Locus Notch Homolog Protein 2; Notch2 Protein; HN2; HJCYS; Neurogenic Locus Notch-Like Protein 2; AGS2
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P704828
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch2; Notch (Drosophila) Homolog 2; Notch receptor 2; Notch Homolog 2 (Drosophila); Notch 2; Notch Homolog 2; Neurogenic Locus Notch Homolog Protein 2; Notch2 Protein; HN2; HJCYS; Neurogenic Locus Notch-Like Protein 2; AGS2
Species:
Human
Source:
HEK293
Cat. No.: HY-P78010
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch3; Notch 3-Like Protein; Prev. CADASIL; CADASIL1; Notch 3; CARASIL1; CASIL; FPLD1; Neurogenic Locus Notch Homolog Protein 3; IMF2; Notch (Drosophila) Homolog 3; LMNS; Notch Homolog 3 (Drosophila); Notch receptor 3; Notch Homolog 3
Species:
Human
Source:
HEK293
Cat. No.: HY-P700804
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch3; Notch 3-Like Protein; Prev. CADASIL; CADASIL1; Notch 3; CARASIL1; CASIL; FPLD1; Neurogenic Locus Notch Homolog Protein 3; IMF2; Notch (Drosophila) Homolog 3; LMNS; Notch Homolog 3 (Drosophila); Notch receptor 3; Notch Homolog 3
Species:
Human
Source:
HEK293
Cat. No.: HY-P78185
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch2; Notch (Drosophila) Homolog 2; Notch receptor 2; Notch Homolog 2 (Drosophila); Notch 2; Notch Homolog 2; Neurogenic Locus Notch Homolog Protein 2; Notch2 Protein; HN2; HJCYS; Neurogenic Locus Notch-Like Protein 2; AGS2
Species:
Human
Source:
HEK293
Cat. No.: HY-P700803
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch3; Notch 3-Like Protein; Prev. CADASIL; CADASIL1; Notch 3; CARASIL1; CASIL; FPLD1; Neurogenic Locus Notch Homolog Protein 3; IMF2; Notch (Drosophila) Homolog 3; LMNS; Notch Homolog 3 (Drosophila); Notch receptor 3; Notch Homolog 3
Species:
Human
Source:
HEK293
Cat. No.: HY-L013
3,961 compounds
Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.
MCE designs a unique collection of 3,961 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.
Cat. No.: HY-187731
CAS No.: 685141-23-5
BXL0124 is an orally effective CD44 inhibitor and Notch signaling pathway inhibitor. BXL0124 has a vitamin D receptor-dependent mechanism and can downregulate the expression of CD44, Notch1/2/3, HES1, OCT4, LAMA5, JAG1, JAG2, NF-κB and DLL1. BXL0124 inhibits c-Myc expression and the levels of phosphorylated ERK, AKT, ErbB2, reduces the level of activated Notch1 receptor and its nuclear localization, decreases the mRNA and protein levels of Jagged-1 and Jagged-2, and inhibits the STAT3 signaling pathway by reducing the formation of the CD44-STAT3-JAK2 complex, while also inhibiting the transcriptional activity of the CD44 promoter in a p53-dependent manner. BXL0124 can induce myoepithelial differentiation and inhibit the self-renewal of cancer stem cell-like cells, cancer cell proliferation, invasion, and growth. BXL0124 can be used in research related to triple-negative breast cancer, basal-like breast cancer, ErbB2-overexpressing mammary tumorigenesis, and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
