PI3K/Akt/eNOS

Pathways Recommended:	PI3K/Akt/mTOR

By Targets:	Akt (5) PI3K (6) AMPK (1) Apolipoprotein (1) Apoptosis (2) Cadherin (2) CaMK (1) Claudin (2) Cytochrome P450 (1) ERK (2) GSK-3 (2) HIF/HIF Prolyl-Hydroxylase (1) JNK (2) LPL Receptor (1) nAChR (1) NF-κB (3) NO Synthase (3) p38 MAPK (3) PPAR (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Tie (2) VEGFR (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (2)

Targets Recommended: PI3K Akt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0721

Neoandrographolide 1 Publications Verification Neoandrographiside	ERK p38 MAPK JNK NF-κB PI3K PPAR GSK-3 CaMK NO Synthase Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of *MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK* signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates *eNOS*, exhibiting anti-inflammatory and hypolipidemic activity .

HY-N0563

Alizarin 1 Publications Verification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450	Cardiovascular Disease Cancer
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and *VEGFR2/eNOS* pathway. Alizarin regulates *PI3K/Akt* and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-NP203

High density lipoprotein (human) HDL (human)	Apolipoprotein NO Synthase LPL Receptor Akt PI3K p38 MAPK	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving *Akt, PI3K* and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

HY-15672

FM19G11	HIF/HIF Prolyl-Hydroxylase	Neurological Disease Cancer
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC₅₀ of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions .

HY-P10580

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream *PI3K/Akt* and *eNOS* pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

HY-P10580A

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream *PI3K/Akt* and *eNOS* pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

HY-N0721R

Neoandrographolide (Standard) Neoandrographiside (Standard)	Reference Standards ERK p38 MAPK JNK NF-κB PI3K PPAR GSK-3 NO Synthase Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Neoandrographolide (Standard) is the analytical standard of Neoandrographolide. This product is intended for research and analytical applications. Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of *MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK* signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates *eNOS*, exhibiting anti-inflammatory and hypolipidemic activity .

HY-P11313

Catestatin (rat) Rat chromogranin A367–387	nAChR Akt	Cardiovascular Disease
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A_367-387). Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC₅₀ = 1.2 μM), and blocks desensitization of norepinephrine release (IC₅₀ = 0.62 μM). Catestatin (rat) exerts antiadrenergic effects through the endothelial *PI3K-AKT-eNOS* pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of ²²Na ⁺ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms .

Cat. No.	Product Name	Type

HY-NP203

High density lipoprotein (human) HDL (human)	Biochemical Assay Reagents
High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving *Akt, PI3K* and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

High density lipoprotein (human)

HDL (human)

Biochemical Assay Reagents

High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .

Cat. No.	Product Name	Target	Research Area

HY-P10580

Vasculotide	Tie PI3K Akt Cadherin Claudin	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream *PI3K/Akt* and *eNOS* pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide with antibiotics reduces lung injury .

HY-P10580A

Vasculotide TFA	Cadherin Tie Claudin PI3K Akt	Cardiovascular Disease Infection Inflammation/Immunology
Vasculotide TFA is a blood-brain barrier (BBB)-penetrant Tie2 agonist. Vasculotide TFA binds to a unique domain of Tie2, induces receptor clustering to drive phosphorylation, activates downstream *PI3K/Akt* and *eNOS* pathways, enhances inter-endothelial cell junctions (such as VE-cadherin and claudin-5), and inhibits inflammatory adhesion molecules, ultimately stabilizing the vascular endothelial barrier and reducing its permeability . Vasculotide TFA alleviates pulmonary microvascular leakage and microcirculatory dysfunction caused by cardiopulmonary bypass, acts as an adjuvant radioprotective agent to reduce acute radiation dermatitis, and promotes BBB recovery after focused ultrasound (FUS). Combination of Vasculotide TFA with antibiotics reduces lung injury .

HY-P11313

Catestatin (rat) Rat chromogranin A367–387	nAChR Akt	Cardiovascular Disease
Catestatin (rat) (Rat chromogranin A367–387) is a potent, reversible, noncompetitive, and noncooperative nicotinic cholinergic antagonist derived from chromogranin A (A_367-387). Catestatin (rat) inhibits norepinephrine release in rat PC12 pheochromocytoma cells (IC₅₀ = 1.2 μM), and blocks desensitization of norepinephrine release (IC₅₀ = 0.62 μM). Catestatin (rat) exerts antiadrenergic effects through the endothelial *PI3K-AKT-eNOS* pathway in rat papillary muscles and isolated cardiomyocytes. Catestatin (rat) maintains mitochondrial membrane potential in I/R cardiomyocytes and increases phosphorylation of AKT at S473, GSK3β at S9, PLB at T17, and eNOS at S1179. Catestatin (rat) reverses desensitization of ²²Na ⁺ uptake. Catestatin (rat) can be used for the study of nicotinic cholinergic receptor regulation and catecholamine release control mechanisms .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0721

Neoandrographolide 1 Publications Verification Neoandrographiside	Structural Classification Acanthaceae Classification of Application Fields Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	ERK p38 MAPK JNK NF-κB PI3K PPAR GSK-3 CaMK NO Synthase Reactive Oxygen Species (ROS) Apoptosis
Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of *MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK* signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates *eNOS*, exhibiting anti-inflammatory and hypolipidemic activity .

HY-N0563

Alizarin 1 Publications Verification	Quinones Classification of Application Fields Anthraquinones Rubiaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Rubia cordifolia L. Source Classification	AMPK VEGFR PI3K Akt NF-κB Cytochrome P450
Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and *VEGFR2/eNOS* pathway. Alizarin regulates *PI3K/Akt* and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer, breast cancer, osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings .

HY-N0721R

Neoandrographolide (Standard) Neoandrographiside (Standard)	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Reference Standards ERK p38 MAPK JNK NF-κB PI3K PPAR GSK-3 NO Synthase Reactive Oxygen Species (ROS) Apoptosis
Neoandrographolide (Standard) is the analytical standard of Neoandrographolide. This product is intended for research and analytical applications. Neoandrographolide is a diterpenoid compound isolated from Andrographis paniculata. Neoandrographolide inhibits osteoclasts differentiation and bone resorption through inhibition of *MAPK/NF-κB/PI3K/AKT/GSK3β/PPAR/CAMK* signaling pathway. Neoandrographolide inhibits apoptosis in rat embryonic ventricular cardiomyocytes. Neoandrographolide inhibits iNOS and the generation of ROS, activates *eNOS*, exhibiting anti-inflammatory and hypolipidemic activity .

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PI3K/Akt/eNOS

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