1. GPCR/G Protein
  2. P2Y Receptor
  3. MRS2768 tetrasodium salt

MRS2768 tetrasodium salt 

Cat. No.: HY-108649A
Handling Instructions

MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro.

For research use only. We do not sell to patients.

MRS2768 tetrasodium salt Chemical Structure

MRS2768 tetrasodium salt Chemical Structure

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Description

MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. MRS2768 tetrasodium salt has a protective effect on cardiomyocytes from ischemic damage in vivo and in vitro[1][2].

In Vitro

MRS2768 (0.01-10000 μM; 24 hours) significantly increases the proliferation of PANC-1 cells[1].

Cell Proliferation Assay[1]

Cell Line: Human pancreatic duct epithelial cells PANC-1
Concentration: 0.01, 0.1, 1, 10, 100, 1000, 10000 μM
Incubation Time: 24 hours
Result: The effect on proliferation of PANC-1 cells was dependent on concentration (0.1 μM to 1 mM). The concentration that elicited a half-maximal response (EC50) in the stimulation of proliferation was 0.8±1.7 μM.
Resulted in a dose- and time-dependent increase of proliferation in PANC-1 cells
In Vivo

MRS2768 (4.44 μg/kg i.v.) pretreatment reduces myocardial damage in mice. MRS2768 has a protective effect on cardiomyocytes from ischemic damage in vivo[2].

Animal Model: Male wild-type mice (C57BL)[2]
Dosage: 4.44 μg/kg
Administration: Injected i.v.; 1 h before myocardial infarct (MI)
Result: Pretreatment reduced myocardial damage. The damage was significantly smaller in mice compare to the untreated mice (25.6±4.5% vs. 39.2±6.3%).
Molecular Weight

728.14

Formula

C₁₅H₁₆N₂Na₄O₁₈P₄

SMILES

O[[email protected]]1[[email protected]]([[email protected]](N2C=CC(NC2=O)=O)O[[email protected]@H]1COP(OP(OP(OP(OC3=CC=CC=C3)(O[Na])=O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MRS2768 tetrasodiumP2Y ReceptorP2Y2protectiveeffectcardiomyocytesischemicdamageInhibitorinhibitorinhibit

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Product name:
MRS2768 tetrasodium salt
Cat. No.:
HY-108649A
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